Published in J Neuropathol Exp Neurol on April 01, 2010
Body fluid biomarkers in Alzheimer's disease. Ann Transl Med (2015) 1.44
The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells. Int J Clin Exp Pathol (2012) 0.77
Selective coregulator function and restriction of steroid receptor chromatin occupancy by Hic-5. Mol Endocrinol (2015) 0.76
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology (1991) 23.01
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology (1989) 16.83
Integrin signaling. Science (1999) 16.44
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol (1997) 6.12
Paxillin: adapting to change. Physiol Rev (2004) 4.48
The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol (2004) 4.40
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem (1992) 4.33
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nat Rev Drug Discov (2007) 4.03
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol Cell Biol (1995) 3.85
JNK phosphorylates paxillin and regulates cell migration. Nature (2003) 3.60
Integrin signaling and cell growth control. Curr Opin Cell Biol (1998) 3.32
Focal adhesion kinase in integrin-mediated signaling. Front Biosci (1999) 2.11
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J Cell Biol (1999) 2.00
The choroid plexus removes beta-amyloid from brain cerebrospinal fluid. Exp Biol Med (Maywood) (2005) 1.97
The inner lives of focal adhesions. Trends Cell Biol (2002) 1.92
Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin. J Cell Sci (1999) 1.72
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. J Neurosci (2002) 1.46
Methods for the detection of paxillin post-translational modifications and interacting proteins by mass spectrometry. J Proteome Res (2005) 1.38
The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A (1993) 1.37
Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin. J Cell Sci (1993) 1.36
The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner. Mol Biol Cell (2001) 1.35
Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells. J Biol Chem (2001) 1.31
Focal adhesion kinase in integrin signaling. Matrix Biol (1997) 1.29
The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type. Neurology (2001) 1.27
Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. J Biol Chem (1994) 1.26
Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix. Mol Biol Cell (2000) 1.25
The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. J Neuroinflammation (2006) 1.25
Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal. Mol Biol Cell (2003) 1.19
Paxillin phosphorylation sites mapped by mass spectrometry. J Cell Sci (2005) 1.18
Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol (2001) 1.15
The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. J Neurosci (2002) 1.15
Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. J Neurosci (2003) 1.13
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. J Cell Biol (2004) 1.11
Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. Mol Cell Biol (1997) 1.08
Rapid impact of beta-amyloid on paxillin in a neural cell line. J Neurosci Res (1997) 1.07
A role for JNK-paxillin signaling in cell migration. Cell Cycle (2004) 1.07
Morphological alterations of the choroid plexus in late-onset Alzheimer's disease. Acta Neuropathol (2000) 1.06
HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription. J Biol Chem (2005) 1.05
The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines. Cancer Res (2003) 1.04
Localization of a novel septin protein, hCDCrel-1, in neurons of human brain. Neuroreport (1998) 1.03
Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator. Mol Endocrinol (2005) 1.03
A LIM protein, Hic-5, functions as a potential coactivator for Sp1. J Cell Biochem (2004) 1.02
Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells. Cancer Res (2006) 1.01
Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease. Biochim Biophys Acta (2006) 0.98
Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease. Cerebrospinal Fluid Res (2004) 0.95
Serine phosphorylation regulates paxillin turnover during cell migration. Cell Commun Signal (2006) 0.91
Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro. J Biol Chem (1996) 0.87
Integrin signalling and the cellular response to ionizing radiation. J Mol Histol (2004) 0.87
Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation. J Cell Biochem (2004) 0.85
The comparative power of the discriminant methods used in toxicological pathology. Toxicol Pathol (2005) 0.84
Integrin-mediated tyrosine phosphorylation and redistribution of paxillin during neuronal adhesion. Exp Cell Res (1997) 0.84
Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Brain Res (2006) 0.84
Altered choroid plexus basement membrane and epithelium in late-onset Alzheimer's disease: an ultrastructural study. Ann N Y Acad Sci (1997) 0.83
Cell adhesion molecule regulation of nucleocytoplasmic trafficking. FEBS Lett (2003) 0.83
Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis. Exp Cell Res (2007) 0.82
Dibutyryl cyclic AMP-induced process formation in astrocytes is associated with a decrease in tyrosine phosphorylation of focal adhesion kinase and paxillin. J Neurobiol (1999) 0.80
Immunohistochemical investigation of actin-anchoring proteins vinculin, talin and paxillin in rat brain following lesion: a moderate reaction, confined to the astroglia of brain tracts. Exp Brain Res (2001) 0.80
Identification and analysis of Hic-5/ARA55 isoforms: Implications for integrin signaling and steroid hormone action. FEBS Lett (2005) 0.79
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain (2008) 5.89
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Chronic traumatic encephalopathy in a National Football League player. Neurosurgery (2005) 4.67
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52
Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med (2007) 3.33
Research evaluation and prospective diagnosis of dementia with Lewy bodies. Arch Neurol (2002) 3.07
Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes. Neurosurgery (2011) 2.59
Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One (2010) 2.49
Chronic traumatic encephalopathy in a national football league player: part II. Neurosurgery (2006) 2.40
Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group. Neuro Oncol (2011) 2.39
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2007) 2.25
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology (2012) 2.19
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci (2003) 2.06
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res (2011) 2.06
Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol (2007) 1.95
Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis. Clin Cancer Res (2005) 1.94
Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci U S A (2009) 1.94
Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. J Neurosurg (2006) 1.93
Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. J Neurochem (2005) 1.91
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res (2006) 1.91
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol (2008) 1.81
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet (2010) 1.81
Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem (2004) 1.81
Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med (2002) 1.74
Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy? J Neurosci (2004) 1.72
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Clin Cancer Res (2003) 1.71
Chronic traumatic encephalopathy (CTE) in a National Football League Player: Case report and emerging medicolegal practice questions. J Forensic Nurs (2010) 1.71
O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort. J Clin Oncol (2006) 1.66
Dermoid inclusion cysts and early spinal cord tethering after fetal surgery for myelomeningocele. N Engl J Med (2002) 1.64
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement. Cell Signal (2004) 1.63
Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A (2013) 1.59
Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide. Neurosurg Focus (2011) 1.55
Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. J Alzheimers Dis (2005) 1.55
Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control (2010) 1.52
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines. Neoplasia (2005) 1.49
Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics. Muscle Nerve (2010) 1.48
Glucocorticoid receptor physiology. Rev Endocr Metab Disord (2007) 1.45
Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking. Mol Cell Biol (2002) 1.42
APOE ε4 increases risk for dementia in pure synucleinopathies. JAMA Neurol (2013) 1.41
IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group. Childs Nerv Syst (2010) 1.39
Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol (2010) 1.39
Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress. J Biol Chem (2006) 1.34
MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest (2013) 1.34
Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line. J Biol Chem (2001) 1.33
Molecular chaperones function as steroid receptor nuclear mobility factors. Proc Natl Acad Sci U S A (2004) 1.32
Regulation of acetylcholine receptor clustering by the tumor suppressor APC. Nat Neurosci (2003) 1.31
Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase. Cancer Res (2008) 1.29
Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis. Am J Pathol (2003) 1.27
Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells. J Biol Chem (2006) 1.25
Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathol (2003) 1.24
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. Am J Pathol (2008) 1.23
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro Oncol (2011) 1.23
Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. Hum Mol Genet (2003) 1.22
Neuropathologic correlates of late-onset major depression. Neuropsychopharmacology (2004) 1.21
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest (2011) 1.20
In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation (2010) 1.20
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro Oncol (2012) 1.19
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. J Neuropathol Exp Neurol (2005) 1.17
Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study. Acta Neuropathol (2012) 1.16
Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener (2013) 1.16
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas. J Transl Med (2007) 1.15
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. J Neurooncol (2008) 1.15
Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. J Cereb Blood Flow Metab (2002) 1.14
Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin. Neurobiol Dis (2006) 1.14
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm (Vienna) (2009) 1.14
Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism. PLoS One (2010) 1.13
Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohort. Neurosurgery (2002) 1.12
Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS. J Neurochem (2011) 1.10
Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. Proc Natl Acad Sci U S A (2011) 1.08
Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis. PLoS One (2010) 1.08
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Exp Neurol (2004) 1.08
Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death. Mol Pharmacol (2008) 1.06
Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels. Mol Cell Endocrinol (2006) 1.06
Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis. Melanoma Res (2015) 1.06
Coactivators and nuclear receptor transactivation. J Cell Biochem (2008) 1.05
The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines. Cancer Res (2003) 1.04
DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. Neuropathology (2008) 1.04
Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. J Neurosci Res (2004) 1.03
Alternative effects of the ubiquitin-proteasome pathway on glucocorticoid receptor down-regulation and transactivation are mediated by CHIP, an E3 ligase. Mol Endocrinol (2005) 1.03
Environmental and occupational risk factors for amyotrophic lateral sclerosis: a case-control study. Neurodegener Dis (2013) 1.03
Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. J Neuropathol Exp Neurol (2002) 1.02
Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol (2011) 1.01
Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol (2011) 1.01
Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells. Cancer Res (2006) 1.01
SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy. JAMA Neurol (2013) 1.01
Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology. Neurobiol Aging (2002) 1.00
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging (2008) 1.00
Altered subcellular distribution of c-Abl in Alzheimer's disease. J Alzheimers Dis (2009) 0.99
Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas. Neurosurgery (2004) 0.99
Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease. Biochim Biophys Acta (2006) 0.98
Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease. J Biol Chem (2008) 0.98
Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas. Am J Surg Pathol (2012) 0.98
Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. Biochemistry (2004) 0.96
Molecular diagnostics of gliomas. Arch Pathol Lab Med (2011) 0.96