Published in J Allergy Clin Immunol on May 01, 2010
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma | NCT00187499
Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med (2012) 4.85
IgE and mast cells in allergic disease. Nat Med (2012) 3.14
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol (2013) 1.86
Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol (2015) 1.70
The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge. Clin Exp Allergy (2014) 1.65
Regulation and function of epithelial secreted phospholipase A2 group X in asthma. Am J Respir Crit Care Med (2013) 1.51
Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev (2011) 1.29
Immunopathology of chronic rhinosinusitis. Allergol Int (2015) 1.28
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest (2012) 1.13
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.10
Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol (2012) 1.09
Mast cell function: a new vision of an old cell. J Histochem Cytochem (2014) 1.08
Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc Natl Acad Sci U S A (2011) 1.05
Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. J Allergy Clin Immunol (2013) 1.04
Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI. J Allergy Clin Immunol (2011) 1.02
Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin. J Allergy Clin Immunol (2012) 1.00
Mast cell proteases as protective and inflammatory mediators. Adv Exp Med Biol (2011) 1.00
Stratified approaches to the treatment of asthma. Br J Clin Pharmacol (2013) 0.98
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis. Biomed Res Int (2015) 0.91
New insights into pathogenesis of exercise-induced bronchoconstriction. Curr Opin Allergy Clin Immunol (2012) 0.88
Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One (2014) 0.88
Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment. Front Physiol (2012) 0.87
TGF-β1: Mediator of a feedback loop in eosinophilic esophagitis--or should we really say mastocytic esophagitis? J Allergy Clin Immunol (2010) 0.86
Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol (2015) 0.86
Emerging molecular phenotypes of asthma. Am J Physiol Lung Cell Mol Physiol (2014) 0.85
Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. PLoS One (2012) 0.85
Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. J Allergy Clin Immunol (2013) 0.84
The nasal methylome and childhood atopic asthma. J Allergy Clin Immunol (2016) 0.82
Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol (2016) 0.82
Update in asthma 2010. Am J Respir Crit Care Med (2011) 0.81
Allergic asthma biomarkers using systems approaches. Front Genet (2014) 0.79
Are mast cells instrumental for fibrotic diseases? Front Pharmacol (2014) 0.79
Epithelial regulation of eicosanoid production in asthma. Pulm Pharmacol Ther (2012) 0.79
Idiopathic microscopic colitis of rhesus macaques: quantitative assessment of colonic mucosa. Anat Rec (Hoboken) (2013) 0.79
Mast cell proteases as pharmacological targets. Eur J Pharmacol (2015) 0.78
Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A (2016) 0.78
Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air. Respir Res (2014) 0.78
Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma. Dis Model Mech (2013) 0.77
Role of cells and mediators in exercise-induced bronchoconstriction. Immunol Allergy Clin North Am (2013) 0.77
YKL-40 protein correlates with the phenotype of asthma. Lung (2015) 0.76
Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. J Immunol (2011) 0.76
Clinical asthma phenotyping: A trial for bridging gaps in asthma management. World J Clin Pediatr (2015) 0.76
Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA. Ann Am Thorac Soc (2013) 0.76
IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight (2016) 0.76
Exercise-Induced Bronchospasm and Allergy. Front Pediatr (2017) 0.75
Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations. Clin Exp Allergy (2017) 0.75
Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors. Front Immunol (2017) 0.75
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases. PLoS One (2015) 0.75
A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report. BMC Cancer (2015) 0.75
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest (2016) 0.75
Non-specific airway hyperreactivity in asthma: a clinical correlate to … what exactly? Clin Exp Allergy (2016) 0.75
Skin microbiome and mast cells. Transl Res (2017) 0.75
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med (2009) 7.11
Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature (1994) 5.73
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med (2002) 4.65
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A (2007) 4.21
Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci U S A (1986) 3.34
Mast cells can enhance resistance to snake and honeybee venoms. Science (2006) 2.72
Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis (1990) 2.45
How much is there really? Why stereology is essential in lung morphometry. J Appl Physiol (1985) (2006) 2.29
Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J Exp Med (2000) 1.98
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest (2006) 1.98
A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome Res (2001) 1.86
Relationship of small airway chymase-positive mast cells and lung function in severe asthma. Am J Respir Crit Care Med (2004) 1.80
If you assume, you can make an ass out of u and me': a decade of the disector for stereological counting of particles in 3D space. J Anat (1996) 1.79
Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis (1993) 1.73
Novel site-specific mast cell subpopulations in the human lung. Thorax (2009) 1.68
Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J Immunol (1996) 1.57
Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin. J Exp Med (2007) 1.41
Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol (2009) 1.39
Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy (2003) 1.37
Murine M290 integrin expression modulated by mast cell activation. Immunity (1994) 1.36
Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med (2000) 1.32
Stem cell factor is a chemotactic factor for human mast cells. J Immunol (1994) 1.29
Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol (2003) 1.20
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res (2007) 1.15
Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. Immunology (1996) 1.09
Novel insights into the biological function of mast cell carboxypeptidase A. Trends Immunol (2009) 1.06
Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol (1989) 1.06
Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. J Biol Chem (2004) 1.05
Intraepithelial mast cells in allergic and nonallergic asthma. Assessment using bronchial brushings. Am Rev Respir Dis (1993) 1.04
Distribution of chymase-containing mast cells in human bronchi. J Histochem Cytochem (1992) 1.03
Phenotyping and cytokine regulation of the BEAS-2B human bronchial epithelial cell: demonstration of inducible expression of the adhesion molecules VCAM-1 and ICAM-1. Am J Respir Cell Mol Biol (1997) 1.03
Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. Proc Natl Acad Sci U S A (1989) 1.01
Appearance of basophils in the sputum of patients with bronchial asthma. Clin Allergy (1975) 0.99
Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis (1993) 0.99
Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc Natl Acad Sci U S A (2005) 0.91
Angiotensin II potentiates methacholine-induced bronchoconstriction in human airway both in vitro and in vivo. Eur Respir J (1995) 0.89
Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation. Lab Invest (1999) 0.89
Human leukaemic (HMC-1) and normal skin mast cells express beta 2-integrins: characterization of beta 2-integrins and ICAM-1 on HMC-1 cells. Scand J Immunol (1997) 0.87
Analysis of MC(T) and MC(TC) mast cells in tissue. Methods Mol Biol (2006) 0.86
Stem cell factor and its soluble receptor (c-kit) in serum of asthmatic patients- correlation with disease severity. BMC Pulm Med (2009) 0.83
Mast cells and cell-to-cell interactions in airways. Am Rev Respir Dis (1991) 0.78
Leukotriene-C4 enhances mucus production from submucosal glands in canine trachea in vivo. Int J Immunopharmacol (1983) 0.78
Azithromycin for prevention of exacerbations of COPD. N Engl J Med (2011) 8.66
Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med (2005) 7.61
T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med (2009) 7.11
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A (2007) 4.21
Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol (2002) 3.66
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med (2014) 3.51
Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med (2004) 2.93
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol (2011) 2.90
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med (2004) 2.81
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med (2007) 2.81
Analysis of a uropathogenic Escherichia coli clonal group by multilocus sequence typing. J Clin Microbiol (2005) 2.81
Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol (2005) 2.65
beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med (2005) 2.45
Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med (2002) 2.24
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24
Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med (2011) 2.21
Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest (2003) 2.09
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A (2010) 2.03
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax (2013) 1.99
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest (2006) 1.98
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Asthma outcomes: biomarkers. J Allergy Clin Immunol (2012) 1.88
Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol (2005) 1.88
The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol (2007) 1.87
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol (2013) 1.79
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas. Clin Cancer Res (2012) 1.76
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med (2012) 1.75
Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75
Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions. Am J Physiol Lung Cell Mol Physiol (2002) 1.69
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology (2007) 1.60
Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol (2009) 1.58
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. J Allergy Clin Immunol (2008) 1.56
Cluster analysis of obesity and asthma phenotypes. PLoS One (2012) 1.56
Regulation and function of epithelial secreted phospholipase A2 group X in asthma. Am J Respir Crit Care Med (2013) 1.51
Phylogenetic analysis of the vertebrate galectin family. Mol Biol Evol (2004) 1.46
Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am J Respir Crit Care Med (2006) 1.46
Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med (2012) 1.42
A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol (2010) 1.39
Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One (2006) 1.34
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol (2010) 1.32
Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev (2011) 1.29
Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol (2004) 1.29
Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol (2003) 1.20
Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol (2007) 1.17
Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med (2005) 1.16
Genotypic analyses of uropathogenic Escherichia coli based on fimH single nucleotide polymorphisms (SNPs). J Med Microbiol (2007) 1.16
High prevalence of enteroinvasive Escherichia coli isolated in a remote region of northern coastal Ecuador. Am J Trop Med Hyg (2007) 1.16
Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease. J Gen Intern Med (2008) 1.16
Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol (2005) 1.14
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest (2012) 1.13
Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc (2014) 1.12
Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines. Eur Urol (2006) 1.12
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med (2006) 1.12
Galectin-7 in the control of epidermal homeostasis after injury. Mol Biol Cell (2008) 1.11
Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med (2009) 1.11
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med (2009) 1.11
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor. Am J Physiol Cell Physiol (2006) 1.11
Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma. Am J Med (2003) 1.10
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.10
A prospective multicenter study of factors associated with hospital admission among adults with acute asthma. Am J Med (2002) 1.10
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem (2009) 1.08
Axonal transport and sorting of herpes simplex virus components in a mature mouse visual system. J Virol (2003) 1.04
Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance. Am J Respir Crit Care Med (2007) 1.02
Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol (2005) 1.01
Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 0.99
A decade of HIV-1 drug resistance in the United States: trends and characteristics in a large protease/reverse transcriptase and co-receptor tropism database from 2003 to 2012. Antivir Ther (2014) 0.99
Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol Lung Cell Mol Physiol (2004) 0.99
Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem (2006) 0.99
Insurance and quality of care for adults with acute asthma. J Gen Intern Med (2002) 0.98
Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol (2011) 0.97
A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy (2013) 0.97
Global spread of mobile antimicrobial drug resistance determinants in human and animal Escherichia coli and Salmonella strains causing community-acquired infections. Clin Infect Dis (2009) 0.96
Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 0.96
The role of mucus in fatal asthma. Am J Med (2003) 0.95
DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol (2010) 0.95