Published in Curr Gerontol Geriatr Res on May 04, 2010
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic "power station". World J Hepatol (2012) 0.83
The prevalence of cardiovascular risk factors in the young and middle-aged rural population in Sarawak, Malaysia. Malays J Med Sci (2012) 0.79
New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people? World J Hepatol (2013) 0.77
Computationally Modeling Lipid Metabolism and Aging: A Mini-review. Comput Struct Biotechnol J (2014) 0.77
Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia. PLoS One (2013) 0.77
Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. Age (Dordr) (2014) 0.75
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest (2002) 21.08
Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39
Regulation of the mevalonate pathway. Nature (1990) 18.25
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell (1997) 17.78
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J (2001) 9.40
Protein sensors for membrane sterols. Cell (2006) 8.62
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A (1999) 7.48
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem (1996) 7.23
Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 6.68
Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A (2000) 5.47
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
Regulation of sterol synthesis in eukaryotes. Annu Rev Genet (2007) 3.47
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A (2009) 3.39
Epidemiology of coronary heart disease: the Framingham study. Am J Med (1984) 3.38
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res (2008) 3.31
Protein oxidation and aging. Free Radic Res (2006) 2.94
Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly? JAMA (1990) 2.32
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem (2003) 2.05
Lipoprotein lipids in older people. Results from the Cardiovascular Health Study. The CHS Collaborative Research Group. Circulation (1992) 1.79
Ischemic heart disease risk factors after age 50. J Chronic Dis (1984) 1.69
Cardiovascular risk factors in the elderly. Am J Cardiol (1989) 1.52
Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation (2005) 1.48
Dual roles for cholesterol in mammalian cells. Proc Natl Acad Sci U S A (2005) 1.43
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem (2000) 1.41
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. Proc Soc Exp Biol Med (2000) 1.13
Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liver. Mech Ageing Dev (2004) 1.10
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. Cardiol Rev (2009) 1.04
Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase. J Biol Chem (1985) 1.03
Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871. J Biol Chem (1994) 1.01
Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats. Exp Gerontol (2005) 1.00
Sex differences in hepatic regulation of cholesterol homeostasis. J Endocrinol (2008) 0.98
Clinical review 91: Female sex hormones and cardiovascular disease in women. J Clin Endocrinol Metab (1997) 0.98
Rat HMGCoA reductase activation in thioacetamide-induced liver injury is related to an increased reactive oxygen species content. J Hepatol (2005) 0.93
The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis. Endocrinology (2003) 0.90
Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. J Cell Biochem (2006) 0.89
Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat. J Clin Invest (1997) 0.89
Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation. Mech Ageing Dev (2007) 0.87
Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats. Exp Gerontol (2009) 0.86
3-Hydroxy-3-methylglutaryl coenzyme A reductase deregulation and age-related hypercholesterolemia: a new role for ROS. Mech Ageing Dev (2005) 0.83
Age-related changes of cholesterol and dolichol biosynthesis in rat liver. Mech Ageing Dev (2002) 0.83
Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. Scand J Gastroenterol (2005) 0.82
Women and heart disease. Basic Res Cardiol (1998) 0.82
Stimulation of autophagy by antilipolytic drugs may rescue rodents from age-associated hypercholesterolemia. Rejuvenation Res (2009) 0.82
Cholesterol: from feeding to gene regulation. Genes Nutr (2007) 0.81
Costs and health consequences of cholesterol screening for asymptomatic older Americans. Arch Intern Med (1991) 0.81
Caloric restrictions affect some factors involved in age-related hypercholesterolemia. J Cell Biochem (2007) 0.80
Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. Biochim Biophys Acta (2005) 0.79
Age-related changes in lipid metabolism in rats: the consequence of moderate food restriction. Biochim Biophys Acta (1988) 0.79
[Hypercholesterolemia in men and women of various age. Part II. The problem of efficacy and safety of statins]. Kardiologiia (2007) 0.77
Stimulation by estradiol benzoate of hepatic beta-hydroxy-beta-methylglutaryl coenzyme a reductase in normal and ovariectomized rats. Steroids (1978) 0.77
Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups. Biogerontology (2004) 0.77
Endocrine regulation of enzyme activity in aging animals of different genotypes. Birth Defects Orig Artic Ser (1978) 0.77
Evidence that physiologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Biochim Biophys Acta (1980) 0.76
Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats: correlation with development of hypercholesterolemia. J Appl Toxicol (2006) 0.76
Sex differences in hepatic regulation of cholesterol homeostasis. J Endocrinol (2008) 0.98
Potential role of nonstatin cholesterol lowering agents. IUBMB Life (2011) 0.93
Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. J Biol Chem (2006) 0.89
Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms. Mol Nutr Food Res (2009) 0.88
Hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in aged female rats. Exp Gerontol (2009) 0.86
Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. FASEB J (2011) 0.86
Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells. Biochim Biophys Acta (2002) 0.85
17beta-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-alpha-mediated signals. Am J Physiol Cell Physiol (2009) 0.84
Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic "power station". World J Hepatol (2012) 0.83
Age-related changes of cholesterol and dolichol biosynthesis in rat liver. Mech Ageing Dev (2002) 0.83
Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells. Scand J Gastroenterol (2005) 0.82
Stimulation of autophagy by antilipolytic drugs may rescue rodents from age-associated hypercholesterolemia. Rejuvenation Res (2009) 0.82
Short-term activation by low 17beta-estradiol concentrations of the Na+/H+ exchanger in rat aortic smooth muscle cells: physiopathological implications. Endocrinology (2003) 0.81
Caloric restrictions affect some factors involved in age-related hypercholesterolemia. J Cell Biochem (2007) 0.80
Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin. Biochimie (2011) 0.80
Nuclear shield: a multi-enzyme task-force for nucleus protection. PLoS One (2010) 0.80
3-hydroxy 3-methylglutaryl coenzyme A reductase inhibition impairs muscle regeneration. J Cell Biochem (2012) 0.78
Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation. Genes Nutr (2014) 0.78
Age- and sex-related differences in extra-hepatic low-density lipoprotein receptor. J Cell Physiol (2011) 0.78
Omega-3 as well as caloric restriction prevent the age-related modifications of cholesterol metabolism. Mech Ageing Dev (2008) 0.78
Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective. J Cell Physiol (2013) 0.77
Xenosensors CAR and PXR at work: impact on statin metabolism. Curr Drug Metab (2011) 0.76
Hypercholesterolemia and 3-hydroxy 3-methylglutaryl Coenzyme A reductase regulation during ageing. ScientificWorldJournal (2009) 0.76
Mechanism underlying long-term regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase during L6 myoblast differentiation. J Cell Biochem (2010) 0.75
3-hydroxy 3-methylglutaryl coenzyme A reductase increase is essential for rat muscle differentiation. J Cell Physiol (2009) 0.75