Increased adipose tissue in male and female estrogen receptor-alpha knockout mice.

PubWeight™: 5.47‹?› | Rank: Top 1%

🔗 View Article (PMC 18832)

Published in Proc Natl Acad Sci U S A on November 07, 2000

Authors

P A Heine1, J A Taylor, G A Iwamoto, D B Lubahn, P S Cooke

Author Affiliations

1: Departments of Veterinary Biosciences and Kinesiology, University of Illinois, Urbana, IL 61802, USA.

Articles citing this

(truncated to the top 100)

In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol (2007) 4.97

Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A (2004) 3.67

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A (2000) 2.83

Endocrine disrupters as obesogens. Mol Cell Endocrinol (2009) 2.80

Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr (2009) 2.71

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol (2003) 2.65

Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61

Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A (2006) 2.59

The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance. Environ Health Perspect (2006) 2.59

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci U S A (2007) 2.59

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev (2015) 2.51

Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res (2008) 2.40

Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant. N Engl J Med (2013) 2.28

Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr (2009) 2.26

The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet (2012) 2.02

The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93

Bisphenol A: Perinatal exposure and body weight. Mol Cell Endocrinol (2009) 1.82

Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS One (2008) 1.81

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest (2011) 1.81

Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes (2009) 1.76

Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab (2009) 1.69

Sex differences in the regulation of body weight. Physiol Behav (2009) 1.68

Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice. Proc Natl Acad Sci U S A (2001) 1.62

Visualization of estrogen receptor transcriptional activation in zebrafish. Endocrinology (2011) 1.62

The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol (2012) 1.53

Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc Natl Acad Sci U S A (2006) 1.53

Reproduction, fat metabolism, and life span: what is the connection? Cell Metab (2013) 1.51

Sexual differences in the control of energy homeostasis. Front Neuroendocrinol (2009) 1.50

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf) (2011) 1.48

Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size. Am J Physiol Regul Integr Comp Physiol (2009) 1.47

Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes. Br J Pharmacol (2004) 1.46

Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem (2008) 1.44

Body composition and bone mineral density after ovarian hormone suppression with or without estradiol treatment. Menopause (2015) 1.43

New insights into osteoporosis: the bone-fat connection. J Intern Med (2012) 1.43

Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J (2010) 1.42

Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity. Trends Endocrinol Metab (2010) 1.41

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab (2008) 1.40

The role of oestrogens in the adaptation of islets to insulin resistance. J Physiol (2009) 1.37

Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet (2008) 1.35

Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int (2008) 1.35

Minireview: Estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology (2009) 1.34

Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance. Eur J Nutr (2011) 1.34

Minireview: the case for obesogens. Mol Endocrinol (2009) 1.33

Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol (2009) 1.33

Metabolic impact of sex hormones on obesity. Brain Res (2010) 1.30

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab (2014) 1.30

Sex steroid actions in male bone. Endocr Rev (2014) 1.26

Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation. J Clin Endocrinol Metab (2012) 1.24

Adipogenesis. Cold Spring Harb Perspect Biol (2012) 1.23

Minireview: Recent advances in extranuclear steroid receptor actions. Endocrinology (2011) 1.20

Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab (2011) 1.20

A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ Health Perspect (2007) 1.19

Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008. PLoS One (2011) 1.19

Sex differences in the physiology of eating. Am J Physiol Regul Integr Comp Physiol (2013) 1.18

Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors. Biochim Biophys Acta (2009) 1.17

The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab (2013) 1.17

Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology (2012) 1.16

An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16

Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice. Environ Health Perspect (2008) 1.15

Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Rep (2014) 1.15

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology (2013) 1.15

Genes associated with membrane-initiated signaling of estrogen and energy homeostasis. Endocrinology (2008) 1.13

The ovarian hormone estradiol plays a crucial role in the control of food intake in females. Physiol Behav (2011) 1.13

Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology (2011) 1.12

Regulation of specific target genes and biological responses by estrogen receptor subtype agonists. Curr Opin Pharmacol (2010) 1.12

Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics (2008) 1.10

Estrogen: a master regulator of bioenergetic systems in the brain and body. Front Neuroendocrinol (2013) 1.10

Female mice and rats exhibit species-specific metabolic and behavioral responses to ovariectomy. Gen Comp Endocrinol (2010) 1.09

Is obesity in women protective against osteoporosis? Diabetes Metab Syndr Obes (2011) 1.09

Estrogen Deficiency and the Origin of Obesity during Menopause. Biomed Res Int (2014) 1.08

Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem (2011) 1.08

Sex-specific differences in lipid and glucose metabolism. Front Endocrinol (Lausanne) (2015) 1.08

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A (2003) 1.06

Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. Mol Cell Biochem (2008) 1.06

Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A (2009) 1.06

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest (2014) 1.05

Obesogens, stem cells and the developmental programming of obesity. Int J Androl (2012) 1.05

Genetically modified mouse models for the study of nonalcoholic fatty liver disease. World J Gastroenterol (2012) 1.04

Cardioprotection in females: a role for nitric oxide and altered gene expression. Heart Fail Rev (2007) 1.04

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res (2010) 1.04

GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology (2013) 1.03

Membrane-localized estrogen receptor α is required for normal organ development and function. Dev Cell (2014) 1.01

Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes (2008) 1.00

Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics (2010) 1.00

Oestrogen modulates hypothalamic control of energy homeostasis through multiple mechanisms. J Neuroendocrinol (2008) 0.99

Altered estrogen receptor expression in skeletal muscle and adipose tissue of female rats fed a high-fat diet. J Appl Physiol (1985) (2011) 0.98

Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes (2012) 0.98

Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology (2012) 0.98

NAFLD, Estrogens, and Physical Exercise: The Animal Model. J Nutr Metab (2011) 0.97

Estrogen sulfotransferase regulates body fat and glucose homeostasis in female mice. Am J Physiol Endocrinol Metab (2010) 0.97

Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats. Physiol Behav (2009) 0.96

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocr Rev (2016) 0.96

Assessing the validity of current mouse genetic models of obsessive-compulsive disorder. Behav Pharmacol (2009) 0.96

Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging. Front Endocrinol (Lausanne) (2012) 0.95

Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus. PLoS One (2010) 0.95

Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways. Diabetes (2008) 0.94

Loss of Estrogen Receptor α Signaling Leads to Insulin Resistance and Obesity in Young and Adult Female Mice. Cardiorenal Med (2012) 0.94

Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice. Bone (2013) 0.94

The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2. Eur J Pharmacol (2011) 0.94

The role of hypothalamic estrogen receptors in metabolic regulation. Front Neuroendocrinol (2014) 0.93

Articles cited by this

METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem (1964) 21.04

Annual deaths attributable to obesity in the United States. JAMA (1999) 8.62

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A (1993) 7.13

Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev (1999) 7.06

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med (1994) 6.59

Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A (1998) 5.86

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab (1995) 3.34

Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A (1998) 3.06

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A (2000) 2.83

Estrogen receptors alpha and beta form heterodimers on DNA. J Biol Chem (1997) 2.39

Cellularity of rat adipose tissue: effects of growth, starvation, and obesity. J Lipid Res (1969) 1.97

Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab (1999) 1.90

Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science (1999) 1.86

Gonadal effects on food intake and adiposity: a metabolic hypothesis. Physiol Behav (1979) 1.65

Determination of metabolic and heart rate responses of rats to treadmill exercise. J Appl Physiol Respir Environ Exerc Physiol (1978) 1.63

Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc Natl Acad Sci U S A (1997) 1.53

Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women. J Clin Endocrinol Metab (1999) 1.44

As obesity rates rise, experts struggle to explain why. Science (1998) 1.31

Menopause, central body fatness, and insulin resistance: effects of hormone-replacement therapy. Coron Artery Dis (1998) 1.29

Disproportional body growth in female estrogen receptor-alpha-inactivated mice. Biochem Biophys Res Commun (1999) 1.16

Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion. Diabetologia (1980) 1.11

Identification of estrogen receptor beta RNA in human breast and abdominal subcutaneous adipose tissue. Biochem Biophys Res Commun (1998) 1.09

Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Investig (1998) 1.09

Effects of ovarian hormones on energy balance and brown adipose tissue thermogenesis. Am J Physiol (1986) 1.08

Energy balance in ovariectomized rats with and without estrogen replacement. Am J Physiol (1980) 1.05

Effects of in vivo estrogen treatment on adipose tissue metabolism and nuclear estrogen receptor binding in isolated rat adipocytes. Mol Cell Endocrinol (1992) 1.03

Ovarian-adrenal interactions in regulation of body weight by female rats. J Comp Physiol Psychol (1972) 1.01

Glucose tolerance and plasma insulin of the rat in relation to the oestrous cycle and sex hormones. Horm Metab Res (1972) 1.00

Normal development of thymus in male and female mice requires estrogen/estrogen receptor-alpha signaling pathway. Endocrine (2000) 0.99

Cytoplasmic 17 beta-[3H]estradiol binding in rat adipose tissues. Endocrinology (1978) 0.96

Role of ovarian hormones in the long-term control of glucose homeostasis. Interaction with insulin, glucagon and epinephrine. Horm Res (1980) 0.96

Nuclear estradiol binding in rat adipocytes. Regional variations and regulatory influences of hormones. Biochim Biophys Acta (1991) 0.95

Effects of ovarian steroids on energy balance in rats fed a highly palatable diet. Metabolism (1991) 0.89

Ovarian hormones influence brown adipose tissue. Pharmacol Biochem Behav (1983) 0.88

Articles by these authors

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature (1991) 9.89

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med (1994) 6.59

Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med (1994) 6.50

A randomized trial of a consultation service to reduce falls in nursing homes. JAMA (1997) 4.55

The endocrinology and developmental biology of the prostate. Endocr Rev (1987) 3.58

The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol (1983) 3.53

Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol (1995) 3.21

A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol Ind Health (1998) 3.18

A role for oestrogens in the male reproductive system. Nature (1997) 2.99

Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst (1993) 2.76

Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci U S A (1997) 2.54

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology (1996) 2.47

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol (1994) 2.37

In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens. Endocrinology (2003) 2.35

The routine use of radiographic spinal displacement analysis: a dissent. J Manipulative Physiol Ther (1999) 2.31

Behavioral effects of estrogen receptor gene disruption in male mice. Proc Natl Acad Sci U S A (1997) 2.29

Legionella pneumophila in water plumbing systems. Lancet (1982) 2.25

Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nat Med (1997) 2.24

Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? J Pediatr (1997) 2.18

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. EMBO J (1994) 2.14

A radiographic assessment of the prevalence of pulp stones in Australians. Aust Dent J (2002) 2.13

Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. J Biol Chem (1993) 2.11

Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice. Endocrinology (1998) 2.05

Bruises in infants and toddlers: those who don't cruise rarely bruise. Puget Sound Pediatric Research Network. Arch Pediatr Adolesc Med (1999) 2.01

Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol. Hum Reprod (2001) 2.00

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. Recent Prog Horm Res (1996) 1.91

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci U S A (2000) 1.90

Estrogenic and antiestrogenic actions of PCBs in the female rat: in vitro and in vivo studies. Reprod Toxicol (1993) 1.89

Impaired sympathetic vascular regulation in humans after acute dynamic exercise. J Physiol (1996) 1.87

Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet (1996) 1.81

Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome. Proc Natl Acad Sci U S A (1988) 1.76

Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. Am J Hum Genet (1989) 1.74

Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants. J Mammary Gland Biol Neoplasia (1997) 1.73

Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis (1993) 1.62

Cranial computed tomography scans in children after minimal head injury with loss of consciousness. Ann Emerg Med (1994) 1.58

Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice. Endocrinology (1998) 1.57

Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene. Horm Behav (1997) 1.56

Stromal-epithelial interactions in adult organs. Cell Differ (1985) 1.55

Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc Natl Acad Sci U S A (1997) 1.53

An assessment of attitudes to, and extent of, the practice of denture marking in South Australia. Aust Dent J (1998) 1.52

Relationship between epidemiologic risk factors and clinicopathologic findings in the sudden infant death syndrome. Pediatrics (1993) 1.52

Epithelial-stromal tissue interaction in paramesonephric (Müllerian) epithelial differentiation. Dev Biol (2001) 1.50

Calcium pyrophosphate dihydrate crystal deposition disease and pseudogout of the acromioclavicular joint: radiographic and pathologic features. J Rheumatol (1993) 1.48

Early newborn hospital discharge and readmission for mild and severe jaundice. Arch Pediatr Adolesc Med (1999) 1.46

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption. J Clin Invest (1997) 1.42

Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene. Neuroendocrinology (1996) 1.42

Tinidazole and metronidazole pharmocokinetics in man and mouse. Antimicrob Agents Chemother (Bethesda) (1969) 1.41

Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol (1990) 1.40

The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J Immunol (1998) 1.40

Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors. Mol Endocrinol (1990) 1.40

Ocular infection with herpes simplex virus type 1: prevention of acute herpetic encephalitis by systemic administration of virus-specific antibody. J Infect Dis (1979) 1.39

A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol (1991) 1.39

A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem (1990) 1.37

Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique. Cancer Res (1997) 1.37

Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers. Clin Cancer Res (1995) 1.37

Reducing antipsychotic drug use in nursing homes. A controlled trial of provider education. Arch Intern Med (1993) 1.37

BiP (GRP78) and endoplasmin (GRP94) are induced following rotavirus infection and bind transiently to an endoplasmic reticulum-localized virion component. J Virol (1998) 1.36

Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle. Circ Res (1982) 1.36

Phosphate buffered, low sodium chloride blood agar medium for Legionella pneumophila. Lancet (1981) 1.35

A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue. Nucleic Acids Res (1990) 1.34

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol (2002) 1.33

Correction of human mucopolysaccharidosis type-VI fibroblasts with recombinant N-acetylgalactosamine-4-sulphatase. Biochem J (1992) 1.32

Lymphocyte reactivity contributes to protection conferred by specific antibody passively transferred to herpes simplex virus-infected mice. Infect Immun (1980) 1.32

Educational program for nursing home physicians and staff to reduce use of non-steroidal anti-inflammatory drugs among nursing home residents: a randomized controlled trial. Med Care (2001) 1.31

Reactions of pediatricians to the recommendation for universal varicella vaccination. Arch Pediatr Adolesc Med (1998) 1.30

Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol (1997) 1.29

Nanonails: a simple geometrical approach to electrically tunable superlyophobic surfaces. Langmuir (2007) 1.28

Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: effects of low versus high doses. Toxicol Appl Pharmacol (2002) 1.28

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev (2001) 1.28

Paracrine regulation of epithelial progesterone receptor by estradiol in the mouse female reproductive tract. Biol Reprod (2000) 1.27

Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer. Mol Carcinog (1996) 1.27

Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects. Horm Behav (1997) 1.26

Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse. Proc Natl Acad Sci U S A (1997) 1.25

Insulin-like growth factor-I: a key regulator of human cancer risk? J Natl Cancer Inst (1999) 1.24

Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta). Horm Metab Res (2003) 1.24

Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinology (1990) 1.23

14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans. Eur Respir J (2010) 1.23

Development and population study of an eight-locus short tandem repeat (STR) multiplex system. J Forensic Sci (1998) 1.22

Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction. Biochem J (1987) 1.22

Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem (1996) 1.22

Estrogen receptors are essential for female sexual receptivity. Endocrinology (1997) 1.22

Imaging findings in a patient with fibrolipomatous hamartoma of the median nerve. AJR Am J Roentgenol (1993) 1.21

Quantification of mechanical and neural components of vagal baroreflex in humans. Hypertension (2001) 1.21

Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice. J Androl (2000) 1.21

Automated quantification of sympathetic beat-by-beat activity, independent of signal quality. J Appl Physiol (1985) (2001) 1.20

Complete androgen insensitivity due to deletion of exon C of the androgen receptor gene highlights the functional importance of the second zinc finger of the androgen receptor in vivo. Mol Endocrinol (1992) 1.20

Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice. Genes Immun (2008) 1.20

Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics (1994) 1.19

Mechanism of estrogen action: lessons from the estrogen receptor-alpha knockout mouse. Biol Reprod (1998) 1.18

In utero exposure of female lambs to testosterone reduces the sensitivity of the gonadotropin-releasing hormone neuronal network to inhibition by progesterone. Endocrinology (1999) 1.18

Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology (1999) 1.18