Published in J Aerosol Med Pulm Drug Deliv on October 01, 2010
Mammalian target of rapamycin: a central node of complex signaling cascades. Int J Clin Exp Pathol (2011) 1.11
Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer. PLoS One (2012) 0.96
DEPTOR ubiquitination and destruction by SCF(β-TrCP). Am J Physiol Endocrinol Metab (2012) 0.80
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37
The TOR pathway: a target for cancer therapy. Nat Rev Cancer (2004) 9.02
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci (2001) 6.11
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell (1992) 6.08
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94
Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol (1994) 5.18
TOR signalling and control of cell growth. Curr Opin Cell Biol (1997) 4.86
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J (1999) 4.80
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol (2004) 4.70
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell (2008) 3.06
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci U S A (1999) 2.19
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene (1995) 2.05
Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res (2006) 1.94
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene (2007) 1.62
Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity. Mol Cancer Ther (2004) 1.60
Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines. Cancer Res (1988) 1.56
Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol (2004) 1.49
Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol (2007) 1.34
Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. Cancer Res (1994) 1.30
Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Gene Ther (2007) 1.22
Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4. Trends Mol Med (2003) 1.21
Targeting uPA/uPAR in prostate cancer. Cancer Treat Rev (2007) 1.19
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol Cancer Ther (2006) 1.09
Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur J Biochem (1998) 1.08
The urokinase-system--role of cell proliferation and apoptosis. Histol Histopathol (2008) 1.08
BCL-2 promotes migration and invasiveness of human glioma cells. FEBS Lett (1998) 1.00
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice. Gene Ther (2007) 0.99
Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2. Exp Cell Res (1999) 0.96
Antimicrobial effects of silver nanoparticles. Nanomedicine (2007) 6.43
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol (2006) 3.30
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Mol Cell Biol (2004) 2.38
The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest. Cancer Res (2006) 2.36
SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med (2007) 1.77
Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. Angew Chem Int Ed Engl (2006) 1.54
The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest. Cancer Res (2005) 1.52
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene (2005) 1.46
Multifunctional nanoparticles possessing a "magnetic motor effect" for drug or gene delivery. Angew Chem Int Ed Engl (2005) 1.44
Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. J Biol Chem (2009) 1.44
Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting. Anal Chem (2006) 1.43
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI. RNA (2005) 1.40
Galactosylated chitosan-g-PEI/DNA complexes-loaded poly(organophosphazene) hydrogel as a hepatocyte targeting gene delivery system. Arch Pharm Res (2010) 1.39
Specific targeting, cell sorting, and bioimaging with smart magnetic silica core-shell nanomaterials. Small (2006) 1.39
Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J (2009) 1.38
Development of microRNA-145 for therapeutic application in breast cancer. J Control Release (2011) 1.28
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis (2004) 1.25
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. Proc Natl Acad Sci U S A (2008) 1.23
Cellular uptake of magnetic nanoparticle is mediated through energy-dependent endocytosis in A549 cells. J Vet Sci (2006) 1.23
Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4. Trends Mol Med (2003) 1.21
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem (2009) 1.20
The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis. FEBS Lett (2007) 1.20
Diabetes and fractures: an overshadowed association. Curr Opin Endocrinol Diabetes Obes (2009) 1.17
Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced Raman spectroscopic dots. Bioconjug Chem (2007) 1.17
MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. Breast Cancer Res (2012) 1.16
Chitosan-graft-polyethylenimine as a gene carrier. J Control Release (2006) 1.15
Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells. Am J Respir Cell Mol Biol (2006) 1.14
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Res (2007) 1.14
Analysis of the extracellular matrix vesicle proteome in mineralizing osteoblasts. J Cell Physiol (2007) 1.14
Size-dependent tissue kinetics of PEG-coated gold nanoparticles. Toxicol Appl Pharmacol (2010) 1.14
Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence. Exp Mol Med (2006) 1.12
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. PLoS Genet (2011) 1.12
Modulation of radiation-induced disturbances of antioxidant defense systems by ginsan. Evid Based Complement Alternat Med (2005) 1.11
Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J Occup Health (2008) 1.10
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol Cancer Ther (2006) 1.09
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells. Carcinogenesis (2008) 1.08
Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1). PLoS One (2011) 1.08
Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. Toxicol In Vitro (2013) 1.08
Galactosylated poly(ethylene glycol)-chitosan-graft-polyethylenimine as a gene carrier for hepatocyte-targeting. J Control Release (2008) 1.08
Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF. J Natl Cancer Inst (2012) 1.07
Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis. Cancer Prev Res (Phila) (2010) 1.07
A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier. Biomaterials (2006) 1.06
Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. Cancer Res (2009) 1.05
High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling. Am J Respir Crit Care Med (2008) 1.05
A combined proteome and microarray investigation of inorganic phosphate-induced pre-osteoblast cells. Mol Cell Proteomics (2005) 1.03
Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways. Oncogene (2004) 1.02
Mannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery. Int J Pharm (2008) 1.01
Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents. Cancer Sci (2009) 1.00
New method to prepare very stable and biocompatible fluorescent silica nanoparticles. Chem Commun (Camb) (2009) 1.00
Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects. Arch Toxicol (2011) 1.00
The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway. Biomaterials (2009) 0.99
An integrated understanding of the physiological response to elevated extracellular phosphate. J Cell Physiol (2013) 0.98
c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation. Mol Cancer Res (2008) 0.97
High dietary inorganic phosphate affects lung through altering protein translation, cell cycle, and angiogenesis in developing mice. Toxicol Sci (2007) 0.97
Mannosylated chitosan nanoparticle-based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells. Mol Cancer Ther (2006) 0.97
Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells. Cancer Lett (2008) 0.97
Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells. Biomaterials (2008) 0.96
Effects of a scapula-oriented shoulder exercise programme on upper limb dysfunction in breast cancer survivors: a randomized controlled pilot trial. Clin Rehabil (2010) 0.96
Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62. ACS Nano (2014) 0.96
Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis. Cancer Res (2007) 0.96
A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signaling, and results in changes in cap-dependent translation. Toxicol Sci (2005) 0.96
Roles of protein kinase B/Akt in lung cancer. Front Biosci (Elite Ed) (2010) 0.96
Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis. Am J Respir Crit Care Med (2008) 0.96
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. Cancer Res (2004) 0.95
Liverome: a curated database of liver cancer-related gene signatures with self-contained context information. BMC Genomics (2011) 0.95
Physical activity and body mass index and their associations with the development of type 2 diabetes in korean men. Am J Epidemiol (2012) 0.94
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy. Clin Exp Metastasis (2012) 0.94
Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors. J Neurosci (2009) 0.94
The impact of duration of one bout treadmill exercise on cell proliferation and central fatigue in rats. J Exerc Rehabil (2013) 0.94
Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart. Biochem J (2012) 0.94
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties. Oncol Rep (2012) 0.93
Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation. J Bone Miner Res (2011) 0.93
Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. J Thorac Oncol (2011) 0.93
Toxicity and clearance of intratracheally administered multiwalled carbon nanotubes from murine lung. J Toxicol Environ Health A (2010) 0.93