Published in PLoS One on May 05, 2010
pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain. Toxins (Basel) (2013) 0.93
Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment. Anticancer Drugs (2016) 0.80
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers. Toxins (Basel) (2016) 0.78
Membrane translocation assay based on proteolytic cleavage: application to diphtheria toxin T domain. Biochim Biophys Acta (2014) 0.78
Expression and purification of truncated diphtheria toxin, DT386, in Escherichia coli: An attempt for production of a new vaccine against diphtheria. Res Pharm Sci (2016) 0.75
Optimization of the Expression of DT386-BR2 Fusion Protein in Escherichia coli using Response Surface Methodology. Adv Biomed Res (2017) 0.75
Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment. Small (2016) 0.75
Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36
Diphtheria toxin: mode of action and structure. Bacteriol Rev (1975) 7.47
One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell (1978) 4.06
Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell (1992) 3.81
Viral nanoparticles as tools for intravital vascular imaging. Nat Med (2006) 2.46
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell (2008) 2.27
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. J Biol Chem (1971) 2.23
Immunotoxins for targeted cancer therapy. AAPS J (2006) 1.86
The elongation factor 2 content of mammalian cells. Assay method and relation to ribosome number. J Biol Chem (1973) 1.78
Ku86 is essential in human somatic cells. Proc Natl Acad Sci U S A (2002) 1.71
Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). J Biol Chem (2004) 1.41
Endothelial precursor cells as a model of tumor endothelium: characterization and comparison with mature endothelial cells. Cancer Res (2003) 1.26
Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein. Proc Natl Acad Sci U S A (1986) 1.23
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clin Cancer Res (2002) 1.17
Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res (1996) 1.15
Targeted toxin therapy for the treatment of cancer. J Natl Cancer Inst (1989) 1.15
High-level expression of active HIV-1 integrase from a synthetic gene in human cells. FASEB J (2000) 1.13
Entry of ADP-ribosylating toxins into cells. Curr Top Microbiol Immunol (1992) 1.13
Kinetics of adenosinediphosphoribosylation of elongation factor 2 in cells exposed to diphtheria toxin. Infect Immun (1981) 1.11
Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194. J Biol Chem (1990) 1.08
The story of a toxic protein, 1888-1992. Protein Sci (1993) 0.96
Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin. Int J Cancer (2005) 0.95
Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors. Clin Cancer Res (2006) 0.93
Toxicology and pharmacokinetics of DTGM, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor, in cynomolgus monkeys. Toxicol Appl Pharmacol (1999) 0.90
Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials. Protein Expr Purif (2004) 0.90
Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Leuk Lymphoma (2004) 0.88
Modulation of the intracellular stability and toxicity of diphtheria toxin through degradation by the N-end rule pathway. EMBO J (1998) 0.88
Diphtheria toxin-interleukin-3 fusion protein (DT(388)IL3) prolongs disease-free survival of leukemic immunocompromised mice. Leukemia (2003) 0.87
Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther (2007) 0.86
Optimizing denileukin diftitox (Ontak) therapy. Future Oncol (2008) 0.84
The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells. Leuk Res (2003) 0.83
The development of the circulating blood volume of the chick embryo. Anat Embryol (Berl) (1975) 0.82
p22 is a novel plasminogen fragment with antiangiogenic activity. Biochemistry (2001) 0.81
VEGF-DT385 toxin conjugate inhibits mammary adenocarcinoma development in a transgenic mouse model of spontaneous tumorigenesis. Breast Cancer Res Treat (2004) 0.80
Cytotoxicity of a recombinant diphtheria toxin-granulocyte colony-stimulating factor fusion protein on human leukemic blast cells. Leuk Lymphoma (1993) 0.78
Variable cytotoxicity of diphtheria toxin 388-granulocyte-macrophage colony-stimulating factor fusion protein for acute myelogenous leukemia stem cells. Exp Hematol (2000) 0.78
Reactivity of murine cytokine fusion toxin, diphtheria toxin390-murine interleukin-3 (DT390-mIL-3), with bone marrow progenitor cells. Blood (1996) 0.78
Synthesis and phosphorylation of cytoskeletal proteins during the in vitro biogenesis of MDCK cell monolayers. J Cell Sci (1989) 0.77
Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol (2012) 2.58
Viral nanoparticles as tools for intravital vascular imaging. Nat Med (2006) 2.46
Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene (2003) 1.59
Histone ubiquitination: a tagging tail unfolds? Bioessays (2002) 1.56
KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. Endocrinology (2013) 1.55
The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest (2010) 1.55
Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells. Nanomedicine (Lond) (2011) 1.49
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. Cancer Res (2005) 1.47
Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett (2010) 1.42
Ghrelin receptor as a novel imaging target for prostatic neoplasms. Prostate (2011) 1.40
Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles. Nat Protoc (2010) 1.34
Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32
S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors. Front Biosci (2005) 1.29
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. Biochem J (2005) 1.27
A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small (2011) 1.22
CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol (2007) 1.21
Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X. Mol Pharm (2012) 1.13
Structural characterization of macroH2A containing chromatin. Biochemistry (2004) 1.11
Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost (2003) 1.08
Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci U S A (2005) 1.07
Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest (2011) 1.07
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Res (2012) 1.05
Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents. PLoS One (2011) 1.02
Established and novel methods of interrogating two-dimensional cell migration. Integr Biol (Camb) (2012) 1.00
Quantitative analysis of cancer metastasis using an avian embryo model. J Vis Exp (2011) 0.97
Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging. Methods Mol Biol (2012) 0.97
Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis. Oncotarget (2011) 0.96
Embryonic protein nodal promotes breast cancer vascularization. Cancer Res (2012) 0.96
Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A (2014) 0.95
Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. J Biol Chem (2012) 0.94
An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis. Biochem Cell Biol (2011) 0.92
Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome. Cancer Res (2013) 0.91
ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res (2014) 0.90
Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res (2013) 0.90
Common phylogenetic origin of protamine-like (PL) proteins and histone H1: Evidence from bivalve PL genes. Mol Biol Evol (2006) 0.90
The chick embryo as an expanding experimental model for cancer and cardiovascular research. Dev Dyn (2013) 0.89
High-throughput screening of one-bead-one-compound peptide libraries using intact cells. ACS Comb Sci (2013) 0.88
Evaluation of nanoparticle uptake in tumors in real time using intravital imaging. J Vis Exp (2011) 0.86
Magnetically attachable stencils and the non-destructive analysis of the contribution made by the underlying matrix to cell migration. Biomaterials (2012) 0.85
Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery. PLoS One (2012) 0.85
Molecular targeted viral nanoparticles as tools for imaging cancer. Methods Mol Biol (2014) 0.84
Re-examining the size/charge paradigm: differing in vivo characteristics of size- and charge-matched mesoporous silica nanoparticles. J Am Chem Soc (2013) 0.83
Imaging the impact of chemically inducible proteins on cellular dynamics in vivo. PLoS One (2012) 0.82
A fast, reproducible and low-cost method for sequence deconvolution of 'on-bead' peptides via 'on-target' maldi-TOF/TOF mass spectrometry. J Mass Spectrom (2010) 0.82
Discovery of novel integrin ligands from combinatorial libraries using a multiplex "beads on a bead" approach. Nano Lett (2012) 0.81
Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer. Breast Cancer Res (2014) 0.80
Invadopodia: a new therapeutic target to block cancer metastasis. Expert Rev Anticancer Ther (2015) 0.80
Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cells. J Nanopart Res (2009) 0.80
Synthesis, radiometal labeling and in vitro evaluation of a targeted PPIX derivative. Appl Radiat Isot (2011) 0.79
Cyclin A2, a novel regulator of EMT. Cell Mol Life Sci (2014) 0.79
Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver. Biochim Biophys Acta (2004) 0.77
Flipping the switch: integrin switching provides metastatic competence. Sci Signal (2014) 0.77
Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR). Integr Biol (Camb) (2015) 0.76
CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway. Sci Rep (2015) 0.76
SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells. Open J Clin Diagn (2013) 0.75
Launching an academic research career. Dis Model Mech (2009) 0.75