Published in J Biol Chem on June 29, 2012
Physiological mechanisms for the modulation of pannexin 1 channel activity. J Physiol (2012) 1.07
Pannexin1 stabilizes synaptic plasticity and is needed for learning. PLoS One (2012) 1.07
The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1. J Gen Physiol (2013) 1.01
Chemotherapeutic drugs induce ATP release via caspase-gated pannexin-1 channels and a caspase/pannexin-1-independent mechanism. J Biol Chem (2014) 0.89
RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma. J Clin Endocrinol Metab (2013) 0.86
Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem (2013) 0.85
Protein-mediated interactions of pancreatic islet cells. Scientifica (Cairo) (2013) 0.85
Gap junctions and cancer: communicating for 50 years. Nat Rev Cancer (2016) 0.83
Intrinsic properties and regulation of Pannexin 1 channel. Channels (Austin) (2014) 0.82
Emerging functions of pannexin 1 in the eye. Front Cell Neurosci (2014) 0.81
Possible role of hemichannels in cancer. Front Physiol (2014) 0.78
The emerging Pannexin 1 signalome: a new nexus revealed? Front Cell Neurosci (2014) 0.78
Connexins and their channels in inflammation. Crit Rev Biochem Mol Biol (2016) 0.77
A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem Dysfunction. J Biol Chem (2016) 0.77
Connexin and pannexin channels in cancer. BMC Cell Biol (2016) 0.76
Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. PLoS One (2016) 0.75
Perspectives on the role of Pannexin 1 in neural precursor cell biology. Neural Regen Res (2016) 0.75
A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis: clues for the treatment of other stress-induced diseases. Acta Biochim Biophys Sin (Shanghai) (2016) 0.75
A quantized mechanism for activation of pannexin channels. Nat Commun (2017) 0.75
Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases. J Membr Biol (2016) 0.75
Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. BMC Cell Biol (2016) 0.75
Management of cutaneous melanoma. N Engl J Med (2004) 9.52
Selection of successive tumour lines for metastasis. Nat New Biol (1973) 5.03
Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst (1970) 4.88
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89
Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci (2011) 3.80
Ischemia opens neuronal gap junction hemichannels. Science (2006) 3.00
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev (2006) 2.87
A ubiquitous family of putative gap junction molecules. Curr Biol (2000) 2.77
The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics (2004) 2.54
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41
In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res (1980) 2.40
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell (2008) 2.27
The WNT/Beta-catenin pathway in melanoma. Front Biosci (2006) 2.09
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05
A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res (2002) 1.97
Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Neural crest stem and progenitor cells. Annu Rev Cell Dev Biol (2006) 1.71
Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Cancer Res (2007) 1.70
Pannexin1 and Pannexin2 expression in the developing and mature rat brain. Brain Res Mol Brain Res (2005) 1.67
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell (2009) 1.45
Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch (2008) 1.45
A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest (2000) 1.45
Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. PLoS One (2010) 1.44
Targeting pannexin1 improves seizure outcome. PLoS One (2011) 1.43
In melanoma, beta-catenin is a suppressor of invasion. Oncogene (2011) 1.40
Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol (2011) 1.29
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt. Pigment Cell Melanoma Res (2009) 1.19
Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. J Biol Chem (2010) 1.18
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene (2011) 1.17
Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest (2011) 1.07
A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis. J Exp Clin Cancer Res (2010) 1.06
Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells. Carcinogenesis (2000) 1.04
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Mol Cell Proteomics (2008) 1.04
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem (2010) 1.03
Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment. J Biol Chem (2010) 1.03
Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum. Cell Signal (2010) 1.01
Quantitative analysis of cancer metastasis using an avian embryo model. J Vis Exp (2011) 0.97
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci (2010) 0.97
Pannexin2 as a novel growth regulator in C6 glioma cells. Oncogene (2009) 0.96
Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2. J Proteome Res (2011) 0.85
Beta-catenin regulates melanocyte dendricity through the modulation of PKCzeta and PKCdelta. Pigment Cell Melanoma Res (2010) 0.82
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci (2007) 2.41
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Mol Cell (2008) 2.29
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta (2007) 2.07
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93
Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway. Blood (2011) 1.84
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
The biochemistry and function of pannexin channels. Biochim Biophys Acta (2012) 1.70
Histone ubiquitination: a tagging tail unfolds? Bioessays (2002) 1.56
KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. Endocrinology (2013) 1.55
Gap junction remodeling in skin repair following wounding and disease. Physiology (Bethesda) (2013) 1.49
Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells. Nanomedicine (Lond) (2011) 1.49
Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res (2006) 1.48
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. J Biol Chem (2005) 1.46
Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell (2009) 1.45
Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl) (2015) 1.45
Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett (2010) 1.42
Order or chaos? An evaluation of the regulation of protein kinase CK2. Biochem Cell Biol (2004) 1.41
Ghrelin receptor as a novel imaging target for prostatic neoplasms. Prostate (2011) 1.40
Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling. Angew Chem Int Ed Engl (2010) 1.37
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. J Biol Chem (2002) 1.37
Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles. Nat Protoc (2010) 1.34
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells. J Biol Chem (2003) 1.32
Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32
Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture. Breast Cancer Res (2005) 1.27
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell (2007) 1.23
Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small (2011) 1.22
Evaluation of mammary gland development and function in mouse models. J Vis Exp (2011) 1.22
Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci (2005) 1.21
The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta. Int J Biol Sci (2005) 1.21
Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction. Circ Res (2011) 1.21
The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cell Signal (2005) 1.19
The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Mol Cell Biol (2005) 1.18
Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res (2005) 1.17
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. J Biol Chem (2002) 1.15
Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol (2007) 1.15
Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. J Biol Chem (2010) 1.14
Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X. Mol Pharm (2012) 1.13
Structural characterization of macroH2A containing chromatin. Biochemistry (2004) 1.11
Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating. Neuron (2008) 1.11
Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. J Biol Chem (2006) 1.10
Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. J Biol Chem (2007) 1.10
Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules. Exp Cell Res (2002) 1.09
Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface. J Cell Sci (2004) 1.09
A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. Am J Hum Genet (2009) 1.08
Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis. Lab Invest (2011) 1.07
Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell Commun Adhes (2006) 1.07
SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling. Brain (2010) 1.06
An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Mol Cell Proteomics (2008) 1.04
The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. J Biol Chem (2006) 1.04
Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations. J Biol Chem (2004) 1.03
ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. J Bone Miner Res (2008) 1.03
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem (2010) 1.03
Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochim Biophys Acta (2009) 1.02
Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents. PLoS One (2011) 1.02
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1. Cancer Res (2010) 1.01
Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions. J Biol Chem (2002) 1.01
Elastin-like polypeptide fusions enhance the accumulation of recombinant proteins in tobacco leaves. Transgenic Res (2006) 1.00
Phosphorylation regulates the stability of the regulatory CK2beta subunit. Oncogene (2002) 0.99
Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Biophys J (2010) 0.99
Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells. Cell Signal (2008) 0.99
Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res (2011) 0.99
The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. J Biol Chem (2004) 0.98
A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling. Sci Signal (2011) 0.98
Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Dev Biol (2008) 0.97
Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging. Methods Mol Biol (2012) 0.97
Mechanisms linking connexin mutations to human diseases. Cell Tissue Res (2014) 0.97
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci (2010) 0.97
Embryonic protein nodal promotes breast cancer vascularization. Cancer Res (2012) 0.96
S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem (2012) 0.96
Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A (2014) 0.95
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem J (2003) 0.95
Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res (2012) 0.95
Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis (2006) 0.94
Diverse subcellular distribution profiles of pannexin 1 and pannexin 3. Cell Commun Adhes (2008) 0.94
Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem (2006) 0.94
Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc Res (2008) 0.93
The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress. Invest Ophthalmol Vis Sci (2008) 0.93
An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis. Biochem Cell Biol (2011) 0.92
Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha. Mol Cell Biol (2009) 0.92
Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques. J Cell Sci (2009) 0.92
CK2 interacting proteins: emerging paradigms for CK2 regulation? Mol Cell Biochem (2005) 0.92
A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biol Reprod (2009) 0.91
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proc Natl Acad Sci U S A (2008) 0.91
Common phylogenetic origin of protamine-like (PL) proteins and histone H1: Evidence from bivalve PL genes. Mol Biol Evol (2006) 0.90
Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells. Methods Enzymol (2010) 0.90
Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res (2013) 0.90
Connexin levels regulate keratinocyte differentiation in the epidermis. J Biol Chem (2007) 0.89
The chick embryo as an expanding experimental model for cancer and cardiovascular research. Dev Dyn (2013) 0.89