Published in Epigenomics on October 01, 2009
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol (2012) 2.42
Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders. Hum Mol Genet (2011) 1.70
Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. J Autism Dev Disord (2012) 1.39
Complexities of Rett syndrome and MeCP2. J Neurosci (2011) 1.35
The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. Neuropsychopharmacology (2012) 1.22
15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet (2011) 1.17
Fetal environment, epigenetics, and pediatric renal disease. Pediatr Nephrol (2010) 1.04
BDNF deregulation in Rett syndrome. Neuropharmacology (2013) 1.02
Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism. PLoS One (2013) 1.02
A genomic point-of-view on environmental factors influencing the human brain methylome. Epigenetics (2011) 1.00
The Role of Epigenetic Change in Autism Spectrum Disorders. Front Neurol (2015) 0.95
Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism. Autism Res Treat (2012) 0.94
Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J Hum Genet (2013) 0.90
Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. Drug Metab Dispos (2015) 0.88
Epigenetic layers and players underlying neurodevelopment. Trends Neurosci (2013) 0.88
The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci (2014) 0.87
Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements. PLoS One (2014) 0.87
Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry (2014) 0.86
Translational research: Rett syndrome and tuberous sclerosis complex. Curr Opin Pediatr (2011) 0.85
Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol (2012) 0.84
Impact of induced pluripotent stem cells on the study of central nervous system disease. Curr Opin Genet Dev (2011) 0.84
Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. J Mol Psychiatry (2014) 0.83
The behavioral phenotype in MECP2 duplication syndrome: a comparison with idiopathic autism. Autism Res (2012) 0.83
Animal models of intellectual disability: towards a translational approach. Clinics (Sao Paulo) (2011) 0.83
Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma. PLoS One (2011) 0.82
Neuroepigenomics: Resources, Obstacles, and Opportunities. Neuroepigenetics (2015) 0.81
Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment. PLoS One (2013) 0.80
DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring Cerebellum. Front Neurosci (2016) 0.77
The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nat Rev Neurosci (2016) 0.77
Training communication abilities in Rett Syndrome through reading and writing. Front Psychol (2013) 0.77
Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder. Epigenomics (2015) 0.77
Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology (2016) 0.75
Epigenetics of Renal Development and Disease. Yale J Biol Med (2016) 0.75
Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure. Neurobiol Dis (2015) 0.75
Knowledge-Guided Bioinformatics Model for Identifying Autism Spectrum Disorder Diagnostic MicroRNA Biomarkers. Sci Rep (2016) 0.75
Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome. Epigenetics Chromatin (2017) 0.75
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function. Genes (Basel) (2017) 0.75
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
Large-scale copy number polymorphism in the human genome. Science (2004) 34.64
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet (1999) 22.84
Structural variation in the human genome. Nat Rev Genet (2006) 21.40
Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature (2008) 20.31
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (1998) 18.36
DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet (1998) 13.27
Role for DNA methylation in genomic imprinting. Nature (1993) 12.65
X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature (2005) 12.06
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet (2006) 11.02
Environmental epigenomics and disease susceptibility. Nat Rev Genet (2007) 11.02
MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (2008) 10.11
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science (2003) 8.81
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell (1992) 8.10
Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
Widespread monoallelic expression on human autosomes. Science (2007) 7.12
Copy-number variations associated with neuropsychiatric conditions. Nature (2008) 6.78
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell (1997) 6.45
Gene body-specific methylation on the active X chromosome. Science (2007) 6.33
Next-generation DNA sequencing techniques. N Biotechnol (2009) 6.02
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet (2004) 5.64
Mechanisms regulating imprinted genes in clusters. Curr Opin Cell Biol (2007) 5.49
X chromosome dosage compensation: how mammals keep the balance. Annu Rev Genet (2008) 5.18
An evaluation of 3C-based methods to capture DNA interactions. Nat Methods (2007) 4.94
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem (2002) 4.70
Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell (1984) 4.44
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci U S A (2007) 4.00
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet (2005) 3.98
Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. Am J Hum Genet (1997) 3.95
Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males. Am J Hum Genet (2005) 3.87
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet (2008) 3.87
Chromosome territories--a functional nuclear landscape. Curr Opin Cell Biol (2006) 3.82
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J Neurosci (2006) 3.69
The rise in autism and the role of age at diagnosis. Epidemiology (2009) 3.44
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev (2006) 3.41
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A (2002) 3.29
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Mol Cell (2005) 3.01
Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. Nature (2008) 2.98
Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A (2005) 2.90
Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet (2004) 2.89
Next-generation sequencing: the race is on. Cell (2008) 2.86
Autism: many genes, common pathways? Cell (2008) 2.63
Large genomic duplicons map to sites of instability in the Prader-Willi/Angelman syndrome chromosome region (15q11-q13). Hum Mol Genet (1999) 2.62
Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome. Hum Mol Genet (2004) 2.61
Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol (2006) 2.49
The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences. Proc Natl Acad Sci U S A (2006) 2.44
Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics (2007) 2.30
Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2006) 2.25
Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem (2003) 2.14
Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr Neurol (2003) 2.14
A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet (2008) 2.13
15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet (2007) 1.99
The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13. Neurobiol Dis (2008) 1.97
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet (2005) 1.87
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A (2007) 1.84
Neuropathology of Rett syndrome. J Child Neurol (2005) 1.83
MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. J Biol Chem (2004) 1.79
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A (2004) 1.79
The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1. Curr Opin Genet Dev (2007) 1.75
Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet (2005) 1.62
Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet (2004) 1.56
Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. BMC Med Genet (2002) 1.53
The nucleosome: a little variation goes a long way. Biochem Cell Biol (2006) 1.51
Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets. BMC Med Genet (2007) 1.49
Rett syndrome: 3-D confocal microscopy of cortical pyramidal dendrites and afferents. Neuroreport (1994) 1.49
Mecp2-null mice provide new neuronal targets for Rett syndrome. PLoS One (2008) 1.45
Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number. J Med Genet (2008) 1.43
Decreased dendritic branching in frontal, motor and limbic cortex in Rett syndrome compared with trisomy 21. J Neuropathol Exp Neurol (1998) 1.41
FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet (2007) 1.39
The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep (2005) 1.38
Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet (2006) 1.37
Spectrum of mutations in the MECP2 gene in patients with infantile autism and Rett syndrome. J Med Genet (2000) 1.34
The neuropathology of autism: a review. J Neuropathol Exp Neurol (2005) 1.34
Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disorders. Biol Psychiatry (2009) 1.32
Silver-Russell and Beckwith-Wiedemann syndromes: opposite (epi)mutations in 11p15 result in opposite clinical pictures. Horm Res (2009) 1.30
Molecular epigenetics of Angelman syndrome. Cell Mol Life Sci (2007) 1.30
Hippocampus in autism: a Golgi analysis. Acta Neuropathol (1996) 1.29
Imprinted noncoding RNAs. Mamm Genome (2008) 1.24
MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression. Hum Mol Genet (2005) 1.21
Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res (2000) 1.20
MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. Hum Genet (2002) 1.18
The phenotypic consequences of MECP2 mutations extend beyond Rett syndrome. Ment Retard Dev Disabil Res Rev (2002) 1.17
Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. Mol Cell Biol (2000) 1.14
15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet (2007) 1.99
Epigenetics in the nervous system. J Neurosci (2008) 1.65
Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples. Hum Mol Genet (2005) 1.62
Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet (2006) 1.37
R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. Proc Natl Acad Sci U S A (2013) 1.23
MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res (2008) 1.19
A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet (2013) 1.19
Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Hum Mol Genet (2012) 1.12
Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Hum Mol Genet (2008) 1.06
Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet (2011) 0.99
MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol Dis (2011) 0.95
Epigenetic layers and players underlying neurodevelopment. Trends Neurosci (2013) 0.88
Investigation of modifier genes within copy number variations in Rett syndrome. J Hum Genet (2011) 0.84