Published in Nat Rev Genet on June 01, 2008
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci U S A (2010) 7.30
A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature (2012) 6.34
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26
Chromatin remodelling during development. Nature (2010) 5.86
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45
Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet (2011) 5.18
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry (2009) 4.12
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol (2012) 3.44
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol (2012) 3.31
Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci (2011) 3.27
Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol (2011) 3.15
Function and information content of DNA methylation. Nature (2015) 3.09
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes (2009) 2.96
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS One (2011) 2.80
DNA methylome analysis using short bisulfite sequencing data. Nat Methods (2012) 2.77
DNA methylation is widespread and associated with differential gene expression in castes of the honeybee, Apis mellifera. Proc Natl Acad Sci U S A (2009) 2.77
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J (2013) 2.70
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. Nucleic Acids Res (2012) 2.67
DNA methylation dynamics of the human preimplantation embryo. Nature (2014) 2.55
Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res (2011) 2.53
Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50
RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res (2008) 2.42
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet (2009) 2.37
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics (2010) 2.34
DNA methylation and memory formation. Nat Neurosci (2010) 2.31
Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development (2012) 2.24
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet (2012) 2.20
Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res (2009) 2.13
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep (2013) 2.10
Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04
Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
Prospects for epigenetic epidemiology. Am J Epidemiol (2009) 2.00
DNA methylation status predicts cell type-specific enhancer activity. EMBO J (2011) 1.98
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing. Nucleic Acids Res (2011) 1.90
Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem (2011) 1.88
Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One (2011) 1.86
5-methylcytosine in RNA: detection, enzymatic formation and biological functions. Nucleic Acids Res (2009) 1.85
DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci (2013) 1.85
RNA-directed DNA methylation. Curr Opin Plant Biol (2011) 1.84
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet (2011) 1.83
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role. Adv Nutr (2012) 1.80
Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res (2012) 1.78
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nat Struct Mol Biol (2012) 1.75
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation. Nature (2015) 1.74
Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation. Cell Cycle (2010) 1.72
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Genome Biol (2013) 1.71
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells. Mol Cell (2016) 1.71
Methylome analysis using MeDIP-seq with low DNA concentrations. Nat Protoc (2012) 1.70
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet (2009) 1.68
Application of OMICS technologies in occupational and environmental health research; current status and projections. Occup Environ Med (2009) 1.67
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities. Nat Neurosci (2012) 1.66
CpG-island promoters drive transcription of human telomeres. RNA (2009) 1.66
The struggle for life of the genome's selfish architects. Biol Direct (2011) 1.64
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science (2012) 1.64
MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome. Proc Natl Acad Sci U S A (2015) 1.63
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol (2010) 1.63
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep (2009) 1.63
Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. Genome Res (2008) 1.61
Targeting DNA methylation for epigenetic therapy. Trends Pharmacol Sci (2010) 1.61
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging (2008) 1.60
The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics (2014) 1.57
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet (2011) 1.56
Regulation of primary response genes. Mol Cell (2011) 1.56
DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer (2008) 1.55
Deposition of histone variant H2A.Z within gene bodies regulates responsive genes. PLoS Genet (2012) 1.55
Probing DNA shape and methylation state on a genomic scale with DNase I. Proc Natl Acad Sci U S A (2013) 1.54
Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting. Genome Res (2012) 1.54
The epigenetic landscape of addiction. Ann N Y Acad Sci (2011) 1.51
Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics (2011) 1.50
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One (2009) 1.49
RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee. Proc Natl Acad Sci U S A (2013) 1.49
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
Reversal of neurological defects in a mouse model of Rett syndrome. Science (2007) 7.09
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (2011) 2.84
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res (2011) 2.51
CpG methylation is targeted to transcription units in an invertebrate genome. Genome Res (2007) 2.47
A temporal threshold for formaldehyde crosslinking and fixation. PLoS One (2009) 2.03
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet (2005) 1.87
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A (2007) 1.84
The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res (2004) 1.79
Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nat Neurosci (2013) 1.74
Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol (2006) 1.67
DNA methylation and Rett syndrome. Hum Mol Genet (2003) 1.62
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55
Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol (2006) 1.52
Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet (2003) 1.44
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A (2003) 1.29
Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci (2013) 1.26
Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Mol Cell Biol (2007) 1.22
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene (2003) 1.21
Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One (2010) 1.17
Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. Brain (2012) 1.14
Genomic approaches reveal unexpected genetic divergence within Ciona intestinalis. J Mol Evol (2005) 1.14
The effect of interspecific oocytes on demethylation of sperm DNA. Proc Natl Acad Sci U S A (2004) 1.14
Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet (2012) 1.10
Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons. Stem Cells (2012) 1.09
Molecular biology. MeCP2 repression goes nonglobal. Science (2003) 1.07
Reversibility of functional deficits in experimental models of Rett syndrome. Biochem Soc Trans (2010) 1.03
MMDiff: quantitative testing for shape changes in ChIP-Seq data sets. BMC Genomics (2013) 1.02
Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet (2006) 1.00
MeCP2 and other methyl-CpG binding proteins. Ment Retard Dev Disabil Res Rev (2002) 0.94
Il2 transcription unleashed by active DNA demethylation. Nat Immunol (2003) 0.93
Putting the DNA back into DNA methylation. Nat Genet (2011) 0.92
MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol (2007) 0.89
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene (2004) 0.89
Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol (2014) 0.87
MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells. Pathobiology (2008) 0.86
MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene (2005) 0.82
Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells. Epigenetics Chromatin (2013) 0.81
A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection. Eur J Immunol (2014) 0.80