Published in J Biomol Struct Dyn on August 01, 2010
TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One (2011) 3.09
Identification of potent EGFR inhibitors from TCM Database@Taiwan. PLoS Comput Biol (2011) 1.61
Identifying HER2 inhibitors from natural products database. PLoS One (2011) 1.01
Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimetic. J Biomol Struct Dyn (2012) 0.93
A conformationally constrained peptidomimetic binds to the extracellular region of HER2 protein. J Biomol Struct Dyn (2010) 0.85
Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional chinese medicine. Evid Based Complement Alternat Med (2014) 0.80
In silico investigation of traditional Chinese medicine compounds to inhibit human histone deacetylase 2 for patients with Alzheimer's disease. Biomed Res Int (2014) 0.78
Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods. BMC Med Genomics (2015) 0.77
Investigation of anti-infection mechanism of lactoferricin and splunc-1. Evid Based Complement Alternat Med (2014) 0.76
An investigation of small GTPases in relation to liver tumorigenesis using traditional Chinese medicine. Biomed Res Int (2014) 0.75
Insight into HIV of IFN-induced myxovirus resistance 2 (MX2) expressed by traditional Chinese medicine. Biomed Res Int (2014) 0.75
In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75
In Silico Investigation of Cytochrome P450 2C9 in relation to Aging Using Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75
Lead screening for CXCR4 of the human HIV infection receptor inhibited by traditional Chinese medicine. Biomed Res Int (2014) 0.75
Lead Screening for Chronic Obstructive Pulmonary Disease of IKK2 Inhibited by Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75
Lead Screening for HIV of C-C Chemokine Receptor Type 5 Receptor Inhibited by Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75
Treatment of acute lymphoblastic leukemia from traditional chinese medicine. Evid Based Complement Alternat Med (2014) 0.75
Investigation of estrogen receptor (ESR1) for breast cancer from traditional Chinese medicine. Biomed Res Int (2014) 0.75
Comparative Proteomics Reveals that Phosphorylation of β Carbonic Anhydrase 1 Might be Important for Adaptation to Drought Stress in Brassica napus. Sci Rep (2016) 0.75
Lead screening for HIV-1 integrase (IN) inhibited by traditional Chinese medicine. Biomed Res Int (2014) 0.75
Molecular dynamics simulation and density functional theory studies on the active pocket for the binding of paclitaxel to tubulin. J Mol Model (2011) 0.75
Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol (2008) 5.19
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell (2007) 4.48
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
Ethylene glycol induces calcium oxalate crystal deposition in Malpighian tubules: a Drosophila model for nephrolithiasis/urolithiasis. Kidney Int (2011) 2.28
Long contiguous stretches of homozygosity in the human genome. Hum Mutat (2006) 2.07
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat Genet (2012) 2.05
The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell (2012) 2.02
Electroluminescence from ZnO/Si-nanotips light-emitting diodes. Nano Lett (2009) 1.92
Data classification with radial basis function networks based on a novel kernel density estimation algorithm. IEEE Trans Neural Netw (2005) 1.83
iSMART: an integrated cloud computing web server for traditional Chinese medicine for online virtual screening, de novo evolution and drug design. J Biomol Struct Dyn (2011) 1.72
Incidence of the mucopolysaccharidoses in Taiwan, 1984-2004. Am J Med Genet A (2009) 1.67
Identification of potent EGFR inhibitors from TCM Database@Taiwan. PLoS Comput Biol (2011) 1.61
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Res (2008) 1.56
Pompe disease in infants: improving the prognosis by newborn screening and early treatment. Pediatrics (2009) 1.56
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest (2011) 1.54
Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells. Proc Natl Acad Sci U S A (2011) 1.53
Mesenchymal stem cell insights: prospects in cardiovascular therapy. Cell Transplant (2014) 1.50
Insights into designing the dual-targeted HER2/HSP90 inhibitors. J Mol Graph Model (2010) 1.46
Tumor necrosis factor-α gene polymorphisms in age-related macular degeneration. Retina (2010) 1.45
Association of the neuronal nicotinic acetylcholine receptor subunit alpha4 polymorphisms with febrile convulsions. Epilepsia (2003) 1.44
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. Cell Rep (2013) 1.43
Association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and mitral valve prolapse syndrome. Am Heart J (2003) 1.43
Kabuki syndrome in a girl with mosaic 45,X/47,XXX and aortic coarctation. Fertil Steril (2007) 1.42
Development and comparison of automated classifiers for glaucoma diagnosis using Stratus optical coherence tomography. Invest Ophthalmol Vis Sci (2005) 1.42
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell (2011) 1.40
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37
Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res (2009) 1.36
Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34
Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine. PLoS Comput Biol (2011) 1.33
Cross-generation and cross-laboratory predictions of Affymetrix microarrays by rank-based methods. J Biomed Inform (2007) 1.32
Protein disorder prediction by condensed PSSM considering propensity for order or disorder. BMC Bioinformatics (2006) 1.31
Drug design for neuropathic pain regulation from traditional Chinese medicine. Sci Rep (2013) 1.30
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet (2012) 1.30
iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan. J Comput Aided Mol Des (2011) 1.28
Mutation analysis of Gaucher disease patients in Taiwan: high prevalence of the RecNciI and L444P mutations. Blood Cells Mol Dis (2006) 1.28
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res (2008) 1.26
Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. Lung Cancer (2008) 1.25
Oxidative DNA damage in pterygium. Mol Vis (2005) 1.23
Genome-wide association study of diabetic retinopathy in a Taiwanese population. Ophthalmology (2011) 1.23
High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan. Mol Biosyst (2011) 1.22
Ligand-based dual target drug design for H1N1: swine flu--a preliminary first study. J Biomol Struct Dyn (2009) 1.22
Investigation into potent inflammation inhibitors from traditional Chinese medicine. Chem Biol Drug Des (2011) 1.21
Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Res (2005) 1.21
Identification of over-expressed proteins in oral squamous cell carcinoma (OSCC) patients by clinical proteomic analysis. Clin Chim Acta (2006) 1.20
The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1. Cancer Res (2008) 1.16
Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan. J Biomed Sci (2010) 1.14
Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? Mol Biosyst (2011) 1.13
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. Am J Ophthalmol (2008) 1.12
Screening from the world's largest TCM database against H1N1 virus. J Biomol Struct Dyn (2011) 1.11
Three-in-one agonists for PPAR-α, PPAR-γ, and PPAR-δ from traditional Chinese medicine. J Biomol Struct Dyn (2012) 1.10
Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J Biol Chem (2010) 1.10
Draft Genome Sequences of Four Strains of Vibrio parahaemolyticus, Three of Which Cause Early Mortality Syndrome/Acute Hepatopancreatic Necrosis Disease in Shrimp in China and Thailand. Genome Announc (2014) 1.09
Identification of hot regions in protein-protein interactions by sequential pattern mining. BMC Bioinformatics (2007) 1.09
Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study. PLoS One (2012) 1.08
β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. J Cell Physiol (2011) 1.07
RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation. J Cell Biochem (2011) 1.06
Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways. J Cell Physiol (2012) 1.06
In silico pharmacology suggests ginger extracts may reduce stroke risks. Mol Biosyst (2011) 1.06
Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha. Circulation (2010) 1.06
Traditional Chinese medicine application in HIV: an in silico study. J Biomol Struct Dyn (2012) 1.06
Potent inhibitor design against H1N1 swine influenza: structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese medicine database. J Biomol Struct Dyn (2011) 1.05
Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. J Appl Physiol (1985) (2011) 1.05
Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. J Pathol (2011) 1.05
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. Carcinogenesis (2007) 1.04
Clinical features and outcomes of disseminated infections caused by non-tuberculous mycobacteria in a university hospital in Taiwan, 2004-2008. Scand J Infect Dis (2010) 1.04
An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material. Biomaterials (2005) 1.04
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension (2013) 1.03
Association of the Slit and Trk-like 1 gene in Taiwanese patients with Tourette syndrome. Pediatr Neurol (2007) 1.03
Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women. Eur J Obstet Gynecol Reprod Biol (2010) 1.03
Discovery of genes related to insecticide resistance in Bactrocera dorsalis by functional genomic analysis of a de novo assembled transcriptome. PLoS One (2012) 1.02
MAGIIC-PRO: detecting functional signatures by efficient discovery of long patterns in protein sequences. Nucleic Acids Res (2006) 1.02
Interleukin gene polymorphisms in age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.02
Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations. Pharmacogenetics (2002) 1.01
Bcl-2 modulation to activate apoptosis in prostate cancer. Mol Cancer Res (2009) 1.01
Identifying HER2 inhibitors from natural products database. PLoS One (2011) 1.01
Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells. Mol Cell Biochem (2009) 1.01
Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart. Mol Cell Biochem (2008) 1.00
Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology (2008) 1.00
Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. PLoS One (2013) 0.99
IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. J Endocrinol (2008) 0.99
Overexpression of a chromatin remodeling factor, RSF-1/HBXAP, correlates with aggressive oral squamous cell carcinoma. Am J Pathol (2011) 0.99
SWEET17, a facilitative transporter, mediates fructose transport across the tonoplast of Arabidopsis roots and leaves. Plant Physiol (2013) 0.99
iPDA: integrated protein disorder analyzer. Nucleic Acids Res (2007) 0.98