Published in Evid Based Complement Alternat Med on May 22, 2014
Using Bayesian networks to analyze expression data. J Comput Biol (2000) 15.98
Cell cycle control and cancer. Science (1994) 10.90
Advances to Bayesian network inference for generating causal networks from observational biological data. Bioinformatics (2004) 4.14
The functional human dihydrofolate reductase gene. J Biol Chem (1984) 3.28
TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One (2011) 3.09
Understanding and managing methotrexate nephrotoxicity. Oncologist (2006) 2.52
Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review. Rheumatology (Oxford) (2004) 2.37
Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest (1985) 2.06
Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum (2004) 2.04
Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study. J Clin Oncol (1998) 1.94
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol (2003) 1.75
Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood (2001) 1.66
Identification of potent EGFR inhibitors from TCM Database@Taiwan. PLoS Comput Biol (2011) 1.61
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr D Biol Crystallogr (2005) 1.60
Drug design by machine learning: support vector machines for pharmaceutical data analysis. Comput Chem (2001) 1.59
Intrinsic and acquired resistance to methotrexate in acute leukemia. N Engl J Med (1996) 1.47
Insights into designing the dual-targeted HER2/HSP90 inhibitors. J Mol Graph Model (2010) 1.46
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. Biochemistry (2001) 1.37
Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine. PLoS Comput Biol (2011) 1.33
Drug design for neuropathic pain regulation from traditional Chinese medicine. Sci Rep (2013) 1.30
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood (1994) 1.29
PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics (2011) 1.27
Ligand-based dual target drug design for H1N1: swine flu--a preliminary first study. J Biomol Struct Dyn (2009) 1.22
Structure-based and ligand-based drug design for HER 2 receptor. J Biomol Struct Dyn (2010) 1.21
Advances in individual prediction of methotrexate toxicity: a review. Br J Haematol (2009) 1.19
Drug-induced crystal nephropathy: an update. Expert Opin Drug Saf (2008) 1.17
Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? Mol Biosyst (2011) 1.13
Polygammaglutamyl metabolites of methotrexate. Biochem Biophys Res Commun (1973) 1.12
Screening from the world's largest TCM database against H1N1 virus. J Biomol Struct Dyn (2011) 1.11
Three-in-one agonists for PPAR-α, PPAR-γ, and PPAR-δ from traditional Chinese medicine. J Biomol Struct Dyn (2012) 1.10
Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study. PLoS One (2012) 1.08
Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. Int J Cancer (2003) 1.08
In silico pharmacology suggests ginger extracts may reduce stroke risks. Mol Biosyst (2011) 1.06
Traditional Chinese medicine application in HIV: an in silico study. J Biomol Struct Dyn (2012) 1.06
Potent inhibitor design against H1N1 swine influenza: structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese medicine database. J Biomol Struct Dyn (2011) 1.05
Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro. Mol Pharmacol (1976) 1.02
Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexiate, 4-amino-4-deoxy-N-10-methylpteroylglutamyl-gamma-glutamate. Biochem Biophys Res Commun (1975) 1.01
Multiple linear regression: accounting for multiple simultaneous determinants of a continuous dependent variable. Circulation (2008) 1.00
Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? J Biomol Struct Dyn (2012) 0.98
Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia. Isr Med Assoc J (2002) 0.97
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. J Pediatr (2009) 0.97
Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia. Haematologica (2006) 0.96
Pharmacogenetics of methotrexate. Pharmacogenomics (2004) 0.96
Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia. Leukemia (2008) 0.95
An update on methotrexate pharmacogenetics in rheumatoid arthritis. Pharmacogenomics (2008) 0.94
The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response. Arthritis Rheum (2011) 0.94
Investigation of silent information regulator 1 (Sirt1) agonists from Traditional Chinese Medicine. J Biomol Struct Dyn (2012) 0.93
Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk Lymphoma (2008) 0.93
Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. J Invest Dermatol (2007) 0.91
Cytogenetic toxicity of methotrexate in mouse bone marrow. Environ Toxicol Pharmacol (2000) 0.89
Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein. J Biomol Struct Dyn (2011) 0.84
A possible strategy against head and neck cancer: in silico investigation of three-in-one inhibitors. J Biomol Struct Dyn (2012) 0.83
Neurochemical markers of brain damage in cerebrospinal fluid during induction treatment of acute lymphoblastic leukemia in children. Pediatr Blood Cancer (2008) 0.83
The pharmacogenetics of methotrexate in inflammatory bowel disease. Pharmacogenet Genomics (2005) 0.82
A novel strategy for designing the selective PPAR agonist by the "sum of activity" model. J Biomol Struct Dyn (2010) 0.81
Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs. Mol Pharmacol (2012) 0.81
Molecular level activation insights from a NR2A/NR2B agonist. J Biomol Struct Dyn (2013) 0.81
Liver histology after current intensified therapy for childhood acute lymphoblastic leukemia: microvesicular fatty change and siderosis are the main findings. Med Pediatr Oncol (2003) 0.80
Methotrexate preconditioning allows sufficient engraftment to confer drug resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity. J Pharmacol Exp Ther (2005) 0.79
Memory enhancement by traditional Chinese medicine? J Biomol Struct Dyn (2012) 0.79
Acute methotrexate toxicity presenting as multiorgan failure and acute pneumonitis: A rare case report. Indian J Crit Care Med (2012) 0.76
3D-QSAR Study on dihydro-1,3,5-triazines and their spiro derivatives as DHFR inhibitors by comparative molecular field analysis (CoMFA). Bioorg Med Chem Lett (2012) 0.76
In Silico Investigation of Cytochrome P450 2C9 in relation to Aging Using Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75
Finding inhibitors of mutant superoxide dismutase-1 for amyotrophic lateral sclerosis therapy from traditional chinese medicine. Evid Based Complement Alternat Med (2014) 0.75
Lead Screening for HIV of C-C Chemokine Receptor Type 5 Receptor Inhibited by Traditional Chinese Medicine. Evid Based Complement Alternat Med (2014) 0.75