Published in J Med Chem on June 10, 2010
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. J Med Chem (2014) 0.82
Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells. PLoS One (2015) 0.78
Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep (2016) 0.78
Angiopoietin-like protein 3 is an indicator of prognosis in esophageal cancer patients. Int J Clin Exp Med (2015) 0.75
Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system. Bioorg Med Chem (2005) 2.38
Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure. Int J Cardiol (2013) 1.56
A seven-helix coiled coil. Proc Natl Acad Sci U S A (2006) 1.48
DSAP: deep-sequencing small RNA analysis pipeline. Nucleic Acids Res (2010) 1.41
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res (2004) 1.36
Identification of alpha-enolase as an autoantigen in lung cancer: its overexpression is associated with clinical outcomes. Clin Cancer Res (2006) 1.29
The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. J Biol Chem (2006) 1.29
Trypsin-induced proteome alteration during cell subculture in mammalian cells. J Biomed Sci (2010) 1.29
Survivin - biology and potential as a therapeutic target in oncology. Onco Targets Ther (2013) 1.25
Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. J Biomed Sci (2011) 1.20
Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification. Anal Chem (2007) 1.20
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Antiviral Res (2008) 1.19
Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of XC847, a 3'-5' oligoribonuclease from Xanthomonas campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.19
Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry (2005) 1.17
Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells. Mol Cancer (2010) 1.17
Aurora kinase inhibitors in preclinical and clinical testing. Expert Opin Investig Drugs (2009) 1.16
Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2009) 1.15
TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. Mol Cell Biol (2009) 1.14
Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J Immunol (2004) 1.13
Solution structure of plant nonspecific lipid transfer protein-2 from rice (Oryza sativa). J Biol Chem (2002) 1.12
Predicting helix-helix interactions from residue contacts in membrane proteins. Bioinformatics (2009) 1.11
Investigations of survivin: the past, present and future. Front Biosci (Landmark Ed) (2011) 1.10
Site-specific protein modification through Cu(I)-catalyzed 1,2,3-triazole formation and its implementation in protein microarray fabrication. Angew Chem Int Ed Engl (2006) 1.10
Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem (2002) 1.10
p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer. Cancer Epidemiol Biomarkers Prev (2004) 1.08
Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin Cancer Res (2011) 1.08
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. J Med Chem (2004) 1.08
Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes. Stem Cells (2009) 1.07
Relationship between protein structures and disulfide-bonding patterns. Proteins (2003) 1.07
Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother (2004) 1.07
Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol Biol Cell (2009) 1.07
Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents. J Med Chem (2002) 1.06
CPDB: a database of circular permutation in proteins. Nucleic Acids Res (2008) 1.05
Relationship between local structural entropy and protein thermostability. Proteins (2004) 1.04
IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer. J Cell Physiol (2015) 1.04
Protein structural similarity search by Ramachandran codes. BMC Bioinformatics (2007) 1.04
Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells. Mol Pharmacol (2004) 1.03
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. J Cell Physiol (2008) 1.03
CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships. Genome Biol (2008) 1.03
Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis. J Natl Compr Canc Netw (2009) 1.02
Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: role of NF-kappaB. Arterioscler Thromb Vasc Biol (2005) 1.01
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers. Mol Cancer (2009) 1.01
Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proc Natl Acad Sci U S A (2008) 1.00
Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma. J Pathol (2013) 1.00
Construction and analysis of a plant non-specific lipid transfer protein database (nsLTPDB). BMC Genomics (2012) 1.00
Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. J Biol Chem (2010) 0.99
Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Free Radic Biol Med (2010) 0.99
Selective oxidation of glycosyl sulfides to sulfoxides using magnesium monoperoxyphthalate and microwave irradiation. J Org Chem (2004) 0.99
Binding mechanism of nonspecific lipid transfer proteins and their role in plant defense. Biochemistry (2004) 0.99
In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells. Biochem Pharmacol (2006) 0.98
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities. J Med Chem (2006) 0.98
A novel cell-penetrating peptide derived from human eosinophil cationic protein. PLoS One (2013) 0.97
Enantioselective Addition of Trimethylsilyl Cyanide to Aldehydes Induced by a New Chiral Ti(IV) Complex. J Org Chem (1998) 0.97
Surface α-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target. PLoS One (2013) 0.97
The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the alpha-Glycosylation of Primary Hydroxy Groups This research was supported by Academia Sinica (Taipei) and the NIH (USA). Angew Chem Int Ed Engl (2001) 0.96
ALA-PDT results in phenotypic changes and decreased cellular invasion in surviving cancer cells. Lasers Surg Med (2009) 0.96
Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells. Biotechnol Bioeng (2005) 0.96
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives. J Med Chem (2010) 0.96
MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells. BMC Med Genomics (2011) 0.96
Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10). Expert Opin Ther Pat (2011) 0.96
Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. J Biol Chem (2004) 0.96
GI-POP: a combinational annotation and genomic island prediction pipeline for ongoing microbial genome projects. Gene (2013) 0.96
Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics (2010) 0.96
A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein. Traffic (2007) 0.96
Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. Phytother Res (2008) 0.95
4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med (2011) 0.95
Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus. Antimicrob Agents Chemother (2011) 0.95
Fine-grained protein fold assignment by support vector machines using generalized npeptide coding schemes and jury voting from multiple-parameter sets. Proteins (2003) 0.95
Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. J Med Chem (2009) 0.95
A reinforced merging methodology for mapping unique peptide motifs in members of protein families. BMC Bioinformatics (2006) 0.94
Mitochondrial proteomics analysis of tumorigenic and metastatic breast cancer markers. Funct Integr Genomics (2011) 0.94
Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3. Stem Cell Reports (2013) 0.94
TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells. BMC Cell Biol (2010) 0.93
A novel oral indoline-sulfonamide agent, N-[1-(4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-isonicotinamide (J30), exhibits potent activity against human cancer cells in vitro and in vivo through the disruption of microtubule. J Pharmacol Exp Ther (2007) 0.93
Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol Cancer (2014) 0.93
A parallel coiled-coil tetramer with offset helices. Biochemistry (2006) 0.93
A synthetic analog of alpha-galactosylceramide induces macrophage activation via the TLR4-signaling pathways. Biochem Pharmacol (2007) 0.93
Characterization of molecular interactions between eosinophil cationic protein and heparin. J Biol Chem (2008) 0.93
Mouse model of membranous nephropathy induced by cationic bovine serum albumin: antigen dose-response relations and strain differences. Nephrol Dial Transplant (2004) 0.93
A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells. Cancer Immunol Immunother (2011) 0.93
Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway. Cancer Lett (2011) 0.93