The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex.

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Published in J Immunol on May 17, 2010

Authors

John S Bridgeman1, Robert E Hawkins, Steve Bagley, Morgan Blaylock, Mark Holland, David E Gilham

Author Affiliations

1: Cell Therapy Group, Cancer Research UK Department of Medical Oncology, Paterson Institute for Cancer Research, Manchester, UK.

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