Published in Biochem Biophys Res Commun on May 21, 2010
Role of basic science in the development of new medicines: examples from the eicosanoid field. J Biol Chem (2012) 1.55
Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase. J Surg Res (2011) 1.44
Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab (2011) 1.20
Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J (2012) 1.06
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med (2013) 1.05
Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta (2014) 1.04
Emerging therapeutic strategies for targeting chronic myeloid leukemia stem cells. Stem Cells Int (2013) 0.93
A high-fat diet induces bone loss in mice lacking the Alox5 gene. Endocrinology (2011) 0.91
New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions. Blood (2012) 0.91
Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. Proc Natl Acad Sci U S A (2014) 0.87
Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase. Neurobiol Aging (2013) 0.84
5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. Infect Immun (2015) 0.84
Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. Br J Pharmacol (2011) 0.83
Novel lipid signaling pathways in Alzheimer's disease pathogenesis. Biochem Pharmacol (2013) 0.83
Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells. J Biol Chem (2014) 0.80
Role of lipoxygenase metabolites of arachidonic acid in enhanced pulmonary artery contractions of female rabbits. Hypertension (2011) 0.80
Leukotrienes in pulmonary arterial hypertension. Immunol Res (2014) 0.79
Functional characterization of genetic enzyme variations in human lipoxygenases. Redox Biol (2013) 0.79
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype. Front Cell Neurosci (2015) 0.78
Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. Hypertension (2015) 0.78
The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart. PLoS One (2015) 0.78
Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives. Biomed Res Int (2015) 0.78
Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms. J Lipid Res (2013) 0.77
5-Lipoxygenase pathway in experimental abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (2014) 0.77
Role of leukotrienes on protozoan and helminth infections. Mediators Inflamm (2012) 0.76
Male gender bias in autism and pediatric autoimmunity. Autism Res (2012) 0.76
Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. Int J Mol Sci (2017) 0.75
Detection of 19 types of para-arachidonic acids in five types of plasma/serum by ultra performance liquid chromatography-tandem mass spectrometry. Int J Clin Exp Med (2015) 0.75
On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid. J Lipid Res (2016) 0.75
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China. World J Emerg Med (2013) 0.75
The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target. Brain Res Bull (2016) 0.75
Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs. PLoS One (2016) 0.75
Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol (2015) 0.75
The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease. Neurochem Res (2015) 0.75
Exploring N(1)-p-fluorobenzyl-cymserine as an inhibitor of 5-lipoxygenase as a candidate for type 2 diabetes and neurodegenerative disorder treatment. CNS Neurol Disord Drug Targets (2014) 0.75
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun (2017) 0.75
Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J (2002) 4.73
5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci (2007) 2.53
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci U S A (2003) 2.17
Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc Natl Acad Sci U S A (2002) 1.97
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem (2003) 1.39
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci U S A (2006) 1.28
ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc Natl Acad Sci U S A (2008) 1.28
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A (2006) 1.12
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood (2002) 1.12
Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J (2002) 1.07
5-Lipoxygenase: mechanisms of regulation. J Lipid Res (2008) 1.03
5-lipoxygenase: regulation and possible involvement in atherosclerosis. Prostaglandins Other Lipid Mediat (2007) 0.98
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm. Proc Natl Acad Sci U S A (2010) 0.96
Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. J Biol Chem (2008) 0.96
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells. Proc Natl Acad Sci U S A (2009) 0.96
Molecular cloning and functional characterization of mouse coactosin-like protein. Biochem Biophys Res Commun (2002) 0.91
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. Biochem J (2009) 0.90
Regulation of 5-lipoxygenase enzyme activity. Biochem Biophys Res Commun (2005) 0.89
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochim Biophys Acta (2008) 0.86
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Proc Natl Acad Sci U S A (2005) 0.85
Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375. Proc Natl Acad Sci U S A (2002) 0.83
Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors. FASEB J (2002) 0.82
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors. FASEB J (2011) 0.82
Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc Natl Acad Sci U S A (2014) 0.82
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development. Proc Natl Acad Sci U S A (2011) 0.81
NMR structure of human coactosin-like protein. J Biomol NMR (2004) 0.79
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. Biochim Biophys Acta (2005) 0.78
Characterization of microsomal, glutathione dependent prostaglandin E synthase. Adv Exp Med Biol (2002) 0.78
5-Lipoxygenase activation by MAPKAPK-2 and ERKs. Adv Exp Med Biol (2003) 0.77
Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes. J Leukoc Biol (2002) 0.77
[In Process Citation]. Lakartidningen (2015) 0.75
Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop. Biochim Biophys Acta (2005) 0.75