Published in Nat Biotechnol on May 23, 2010
Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proc Natl Acad Sci U S A (2011) 2.14
Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth. Nat Mater (2012) 2.12
Real-time, aptamer-based tracking of circulating therapeutic agents in living animals. Sci Transl Med (2013) 1.79
Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye. Nat Nanotechnol (2012) 1.61
Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol (2013) 1.60
Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy. PLoS One (2015) 1.49
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study. EBioMedicine (2015) 1.36
Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. Biosens Bioelectron (2011) 1.35
Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem (2012) 1.34
Theoretical design and analysis of multivolume digital assays with wide dynamic range validated experimentally with microfluidic digital PCR. Anal Chem (2011) 1.32
Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range. Nat Commun (2011) 1.30
Plasma tau levels in Alzheimer's disease. Alzheimers Res Ther (2013) 1.30
The Human Eye Proteome Project: perspectives on an emerging proteome. Proteomics (2013) 1.23
Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Proc Natl Acad Sci U S A (2014) 1.20
Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range. Anal Chem (2011) 1.19
Microfluidic Western blotting. Proc Natl Acad Sci U S A (2012) 1.19
Attomolar detection of a cancer biomarker protein in serum by surface plasmon resonance using superparamagnetic particle labels. Angew Chem Int Ed Engl (2010) 1.18
Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Nat Nanotechnol (2014) 1.18
New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences. Proteomics (2012) 1.14
Microfluidic integration for automated targeted proteomic assays. Proc Natl Acad Sci U S A (2012) 1.09
Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS One (2011) 1.09
Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers. PLoS One (2011) 1.07
Antibody colocalization microarray: a scalable technology for multiplex protein analysis in complex samples. Mol Cell Proteomics (2011) 1.02
Single molecule enzyme-linked immunosorbent assays: theoretical considerations. J Immunol Methods (2012) 1.01
Ultrasensitive DNA microarray biosensing via in situ RNA transcription-based amplification and nanoparticle-enhanced SPR imaging. J Am Chem Soc (2011) 1.00
Screening for colorectal cancer: established and emerging modalities. Nat Rev Gastroenterol Hepatol (2011) 0.99
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays. Mol Cell Proteomics (2010) 0.99
Point-of-care technologies for molecular diagnostics using a drop of blood. Trends Biotechnol (2014) 0.99
Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma. ACS Nano (2013) 0.98
Multiplexed protein quantification with barcoded hydrogel microparticles. Anal Chem (2010) 0.97
Fifth-generation digital immunoassay for prostate-specific antigen by single molecule array technology. Clin Chem (2011) 0.94
Ultrasensitive multiplexed microRNA quantification on encoded gel microparticles using rolling circle amplification. Anal Chem (2011) 0.93
Ultrasensitive on-chip immunoassays with a nanoparticle-assembled photonic crystal. ACS Nano (2012) 0.93
Glucose oxidase-catalyzed growth of gold nanoparticles enables quantitative detection of attomolar cancer biomarkers. Anal Chem (2014) 0.92
Computational imaging, sensing and diagnostics for global health applications. Curr Opin Biotechnol (2013) 0.92
Gold Nanoparticles for In Vitro Diagnostics. Chem Rev (2015) 0.92
Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation. Sci Rep (2013) 0.91
Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. J Am Chem Soc (2014) 0.91
Oil-sealed femtoliter fiber-optic arrays for single molecule analysis. Lab Chip (2012) 0.91
Identification and diagnostic utility of Leishmania infantum proteins found in urine samples from patients with visceral leishmaniasis. Clin Vaccine Immunol (2012) 0.89
Bringing single-molecule spectroscopy to macromolecular protein complexes. Trends Biochem Sci (2012) 0.88
Scaffold/Extracellular matrix hybrid constructs for bone-tissue engineering. Adv Healthc Mater (2012) 0.88
Microfluidics for single-cell genetic analysis. Lab Chip (2014) 0.88
Sparse Proteomics Analysis - a compressed sensing-based approach for feature selection and classification of high-dimensional proteomics mass spectrometry data. BMC Bioinformatics (2017) 0.88
Translational actomyosin research: fundamental insights and applications hand in hand. J Muscle Res Cell Motil (2012) 0.87
Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity. Nat Commun (2014) 0.87
Plasma β-amyloid in Alzheimer's disease and vascular disease. Sci Rep (2016) 0.86
Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen. ACS Nano (2013) 0.86
CSF and plasma amyloid-β temporal profiles and relationships with neurological status and mortality after severe traumatic brain injury. Sci Rep (2014) 0.85
Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics. J Transl Med (2015) 0.85
Plasma neurofilament light chain predicts progression in progressive supranuclear palsy. Ann Clin Transl Neurol (2016) 0.84
Optical methods for single molecule detection and analysis. Anal Chem (2012) 0.84
Real-time electrochemical monitoring of adenosine triphosphate in the picomolar to micromolar range using graphene-modified electrodes. Anal Chem (2013) 0.84
Suspended, micron-scale corner cube retroreflectors as ultra-bright optical labels. J Vac Sci Technol B Microelectron Nanometer Struct Process Meas Phenom (2011) 0.84
Single nanoparticle detection for multiplexed protein diagnostics with attomolar sensitivity in serum and unprocessed whole blood. Anal Chem (2013) 0.84
Oil-isolated hydrogel microstructures for sensitive bioassays on-chip. Anal Chem (2013) 0.84
High-throughput analysis and protein engineering using microcapillary arrays. Nat Chem Biol (2015) 0.83
Antibodies covalently immobilized on actin filaments for fast myosin driven analyte transport. PLoS One (2012) 0.82
High-density arrays of submicron spherical supported lipid bilayers. Anal Chem (2012) 0.82
Blood-Based Proteomic Biomarkers of Alzheimer's Disease Pathology. Front Neurol (2015) 0.81
Cerebrospinal fluid analysis in Alzheimer's disease: technical issues and future developments. J Neurol (2014) 0.81
Measuring fate and rate of single-molecule competition of amplification and restriction digestion, and its use for rapid genotyping tested with hepatitis C viral RNA. Angew Chem Int Ed Engl (2014) 0.81
Toward rapid, high-sensitivity, volume-constrained biomarker quantification and validation using backscattering interferometry. Anal Chem (2014) 0.81
Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. Front Cell Infect Microbiol (2015) 0.81
Rapid and sensitive microRNA detection with laminar flow-assisted dendritic amplification on power-free microfluidic chip. PLoS One (2012) 0.81
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia. Neurology (2016) 0.80
DNAzyme footprinting: detecting protein-aptamer complexation on surfaces by blocking DNAzyme cleavage activity. J Am Chem Soc (2013) 0.80
Improving precision of proximity ligation assay by amplified single molecule detection. PLoS One (2013) 0.80
Ultrasensitive HIV-1 p24 detects single infected cells and differences in reservoir induction by latency-reversal agents. J Virol (2017) 0.80
Tethered-bead, immune sandwich assay. Biosens Bioelectron (2014) 0.80
Emerging technologies to increase ligand binding assay sensitivity. AAPS J (2014) 0.79
A highly parallel microfluidic droplet method enabling single-molecule counting for digital enzyme detection. Biomicrofluidics (2014) 0.79
Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma. Biosens Bioelectron (2013) 0.79
Sensitive single-molecule protein quantification and protein complex detection in a microarray format. Proteomics (2011) 0.79
Floating Droplet Array: An Ultrahigh-Throughput Device for Droplet Trapping, Real-time Analysis and Recovery. Micromachines (Basel) (2015) 0.79
Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury. J Neurotrauma (2016) 0.79
Next generation ligand binding assays-review of emerging technologies' capabilities to enhance throughput and multiplexing. AAPS J (2014) 0.78
Differential immunodetection of toxin B from highly virulent Clostridium difficile BI/NAP-1/027. J Clin Microbiol (2015) 0.78
Laminated microfluidic system for small sample protein analysis. Biomicrofluidics (2014) 0.78
Salivary diagnostics using a portable point-of-service platform: a review. Clin Ther (2015) 0.78
Serum neurofilament light protein predicts clinical outcome in traumatic brain injury. Sci Rep (2016) 0.78
Detection of interferon alpha protein reveals differential levels and cellular sources in disease. J Exp Med (2017) 0.77
Ultra-sensitive detection of tumorigenic cellular impurities in human cell-processed therapeutic products by digital analysis of soft agar colony formation. Sci Rep (2015) 0.77
High-throughput formation of lipid bilayer membrane arrays with an asymmetric lipid composition. Sci Rep (2014) 0.77
Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry. Sci Rep (2015) 0.77
Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool. J Clin Microbiol (2015) 0.77
Ultrasensitive fluorescence immunoassay for detection of ochratoxin A using catalase-mediated fluorescence quenching of CdTe QDs. Nanoscale (2016) 0.77
Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring. Sci Rep (2015) 0.77
Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays. J Am Chem Soc (2013) 0.77
Post-genomics nanotechnology is gaining momentum: nanoproteomics and applications in life sciences. OMICS (2014) 0.77
Quantifying Nanomolar Protein Concentrations Using Designed DNA Carriers and Solid-State Nanopores. Nano Lett (2016) 0.77
Fluid biomarkers for mild traumatic brain injury and related conditions. Nat Rev Neurol (2016) 0.77
Protein Quantification Using Controlled DNA Melting Transitions in Bivalent Probe Assemblies. Anal Chem (2015) 0.77
Magnetic ligation method for quantitative detection of microRNAs. Adv Healthc Mater (2014) 0.76
Improved porous silicon microarray based prostate specific antigen immunoassay by optimized surface density of the capture antibody. Anal Chim Acta (2013) 0.76
Metal-linked Immunosorbent Assay (MeLISA): the Enzyme-Free Alternative to ELISA for Biomarker Detection in Serum. Theranostics (2016) 0.76
On-chip spectrophotometry for bioanalysis using microring resonators. Biomed Opt Express (2011) 0.76
Multiplexed fluorescent microarray for human salivary protein analysis using polymer microspheres and fiber-optic bundles. J Vis Exp (2013) 0.76
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders. Alzheimers Dement (Amst) (2016) 0.76
Single cell proteomics in biomedicine: High-dimensional data acquisition, visualization, and analysis. Proteomics (2017) 0.76
The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics (2002) 16.08
Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science (2001) 10.93
Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science (2003) 8.17
Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA (2008) 5.25
Label-free, single-molecule detection with optical microcavities. Science (2007) 4.64
Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood. Nat Biotechnol (2008) 4.40
Matrix-insensitive protein assays push the limits of biosensors in medicine. Nat Med (2009) 3.58
Drivers of biodiagnostic development. Nature (2009) 3.28
Trends in biomarker research for cancer detection. Lancet Oncol (2001) 2.46
Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy. Proc Natl Acad Sci U S A (2009) 2.33
A decade of development in immunoassay methodology. Clin Chem (1990) 2.01
Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem (2007) 1.84
Ultrasensitive assays for proteins. Analyst (2007) 1.35
Lowering the detection limits of HIV-1 viral load using real-time immuno-PCR for HIV-1 p24 antigen. Am J Clin Pathol (2004) 1.33
Theoretical limitations on immunoassay sensitivity. Current practice and potential advantages of fluorescent Eu3+ chelates as non-radioisotopic tracers. J Immunol Methods (1986) 1.30
Detection of protein analytes via nanoparticle-based bio bar code technology. Anal Chem (2006) 1.30
Sensitivity by combination: immuno-PCR and related technologies. Analyst (2008) 1.25
Current state and future directions of neurochemical biomarkers for Alzheimer's disease. Clin Chem Lab Med (2007) 1.24
Biomarkers for Alzheimer's disease--clinical needs and application. J Alzheimers Dis (2005) 1.21
Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano Lett (2006) 1.18
Protein quantification in complex mixtures by solid phase single-molecule counting. Anal Chem (2009) 1.17
Stochastic inhibitor release and binding from single-enzyme molecules. Proc Natl Acad Sci U S A (2007) 1.14
Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays. J Am Chem Soc (2006) 1.13
Distinct and long-lived activity states of single enzyme molecules. J Am Chem Soc (2008) 1.10
How sensitive is a prostate-specific antigen measurement? How sensitive does it need to be? Arch Pathol Lab Med (2004) 0.98
Duplexed sandwich immunoassays on a fiber-optic microarray. Anal Chim Acta (2005) 0.97
Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci (2004) 5.10
Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell (2006) 4.93
Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A (2003) 4.80
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A (2005) 3.15
Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry (2003) 2.85
Physical discipline and children's adjustment: cultural normativeness as a moderator. Child Dev (2005) 2.39
Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem (2006) 2.32
Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. J Am Chem Soc (2005) 2.21
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00
Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect (2005) 1.83
Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle. Clin Chem (2008) 1.72
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur J Neurosci (2006) 1.69
Parent discipline practices in an international sample: associations with child behaviors and moderation by perceived normativeness. Child Dev (2010) 1.65
What conservation biologists can do to counter trap-neuter-return: response to Longcore et al. Conserv Biol (2010) 1.58
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
fleQ, the gene encoding the major flagellar regulator of Pseudomonas aeruginosa, is sigma70 dependent and is downregulated by Vfr, a homolog of Escherichia coli cyclic AMP receptor protein. J Bacteriol (2002) 1.36
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization. FASEB J (2004) 1.35
The peer group as a context: mediating and moderating effects on relations between academic achievement and social functioning in Chinese children. Child Dev (2003) 1.35
Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem (2009) 1.35
Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study. Resuscitation (2012) 1.31
Mechanistic aspects of horseradish peroxidase elucidated through single-molecule studies. J Am Chem Soc (2009) 1.23
Artificial noses. Annu Rev Biomed Eng (2011) 1.21
Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range. Anal Chem (2011) 1.19
Very high density sensing arrays. Chem Rev (2008) 1.19
Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano Lett (2006) 1.18
Relations of effortful control, reactive undercontrol, and anger to Chinese children's adjustment. Dev Psychopathol (2007) 1.14
Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway. Int J Biochem Cell Biol (2013) 1.14
Stochastic inhibitor release and binding from single-enzyme molecules. Proc Natl Acad Sci U S A (2007) 1.14
Fluorescence-based fibre optic arrays: a universal platform for sensing. Chem Soc Rev (2003) 1.14
Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays. J Am Chem Soc (2006) 1.13
PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem (2006) 1.12
Simultaneously monitoring gene expression kinetics and genetic noise in single cells by optical well arrays. Anal Chem (2004) 1.11
Distinct and long-lived activity states of single enzyme molecules. J Am Chem Soc (2008) 1.10
In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147. PLoS One (2012) 1.10
Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci (2011) 1.09
Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS One (2011) 1.09
Intelligent medical diagnostics via molecular logic. J Am Chem Soc (2009) 1.09
Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay. Anal Chem (2009) 1.08
Infochemistry and infofuses for the chemical storage and transmission of coded information. Proc Natl Acad Sci U S A (2009) 1.07
Characterization of DNA-binding specificity and analysis of binding sites of the Pseudomonas aeruginosa global regulator, Vfr, a homologue of the Escherichia coli cAMP receptor protein. Microbiology (2006) 1.07
Corporal punishment of children in nine countries as a function of child gender and parent gender. Int J Pediatr (2010) 1.07
Isolation and detection of single molecules on paramagnetic beads using sequential fluid flows in microfabricated polymer array assemblies. Lab Chip (2011) 1.06
Optical fiber-based biosensors. Anal Bioanal Chem (2004) 1.05
Detecting biological warfare agents. Emerg Infect Dis (2005) 1.04
High-density, microsphere-based fiber optic DNA microarrays. Biosens Bioelectron (2003) 1.03
Living bacterial cell array for genotoxin monitoring. Anal Chem (2004) 1.02
Detection of Salmonella spp. using microsphere-based, fiber-optic DNA microarrays. Anal Chem (2005) 1.02
Direct detection of bacterial genomic DNA at sub-femtomolar concentrations using single molecule arrays. Anal Chem (2013) 1.02
Single molecule enzyme-linked immunosorbent assays: theoretical considerations. J Immunol Methods (2012) 1.01
Genetic structure and evolved malaria resistance in Hawaiian honeycreepers. Mol Ecol (2007) 1.01
CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistance. Prostate (2014) 1.01
Multiplexed single molecule immunoassays. Lab Chip (2013) 0.99
Mother and father socially desirable responding in nine countries: Two kinds of agreement and relations to parenting self-reports. Int J Psychol (2014) 0.98
Duplexed sandwich immunoassays on a fiber-optic microarray. Anal Chim Acta (2005) 0.97
Radiation-induced cellular senescence results from a slippage of long-term G2 arrested cells into G1 phase. Cell Cycle (2013) 0.97
Low dose histone deacetylase inhibitor, LBH589, potentiates anticancer effect of docetaxel in epithelial ovarian cancer via PI3K/Akt pathway in vitro. Cancer Lett (2012) 0.96
Regulation of expression of the stress response gene, Osp94: identification of the tonicity response element and intracellular signalling pathways. Biochem J (2004) 0.95
Victimization in South Korean children's peer groups. J Abnorm Child Psychol (2002) 0.95
Relations of parenting style to Chinese children's effortful control, ego resilience, and maladjustment. Dev Psychopathol (2009) 0.94
Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Circulation (2005) 0.94