Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMC 4472305)

Published in Nat Nanotechnol on December 01, 2014

Authors

Shana O Kelley1, Chad A Mirkin2, David R Walt3, Rustem F Ismagilov4, Mehmet Toner5, Edward H Sargent6

Author Affiliations

1: Department of Pharmaceutical Sciences and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
2: Department of Chemistry, International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, USA.
3: Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.
4: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
5: Center for Bioengineering in Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
6: Department of Computer and Electrical Engineering, University of Toronto, Toronto, Ontario M5S 1A4, Canada.

Articles citing this

Reaction-diffusion processes at the nano- and microscales. Nat Nanotechnol (2016) 0.90

Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements. Lab Chip (2015) 0.86

Ultrasensitive surface-enhanced Raman scattering detection in common fluids. Proc Natl Acad Sci U S A (2015) 0.80

Ultrasensitive HIV-1 p24 detects single infected cells and differences in reservoir induction by latency-reversal agents. J Virol (2017) 0.80

Challenges and opportunities for translating medical microdevices: insights from the programmable bio-nano-chip. Bioanalysis (2016) 0.80

Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics. J Leukoc Biol (2016) 0.78

On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring. Front Bioeng Biotechnol (2015) 0.78

High-Throughput Electrochemical Microfluidic Immunoarray for Multiplexed Detection of Cancer Biomarker Proteins. ACS Sens (2016) 0.78

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation. Sci Adv (2015) 0.77

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders. Adv Drug Deliv Rev (2015) 0.77

Hierarchical organization and molecular diffusion in gold nanorod/silica supercrystal nanocomposites. Nanoscale (2016) 0.76

Ultrasensitive visual read-out of nucleic acids using electrocatalytic fluid displacement. Nat Commun (2015) 0.76

Recent Advances in Silicon Nanomaterial-Based Fluorescent Sensors. Sensors (Basel) (2017) 0.75

Direct ultrasensitive electrochemical biosensing of pathogenic DNA using homogeneous target-initiated transcription amplification. Sci Rep (2016) 0.75

Next Generation Programmable Bio-Nano-Chip System for On-Site Detection in Oral Fluids. J Drug Abuse (2015) 0.75

Evaluation of disposable microfluidic chip design for automated and fast Immunoassays. Biomicrofluidics (2017) 0.75

Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer. ACS Nano (2015) 0.75

A Wash-Free Homogeneous Colorimetric Immunoassay Method. Theranostics (2016) 0.75

Fe3O4 nanoparticles on graphene oxide sheets for isolation and ultrasensitive amperometric detection of cancer biomarker proteins. Biosens Bioelectron (2016) 0.75

Lab-on-chip systems for integrated bioanalyses. Essays Biochem (2016) 0.75

A Multiplexed, Two-Electrode Platform for Biosensing Based on DNA-Mediated Charge Transport. Langmuir (2015) 0.75

Dimethyl adipimidate/Thin film Sample processing (DTS); A simple, low-cost, and versatile nucleic acid extraction assay for downstream analysis. Sci Rep (2015) 0.75

Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins. Lab Chip (2017) 0.75

Rapid prototyping of all-solution-processed multi-lengthscale electrodes using polymer-induced thin film wrinkling. Sci Rep (2017) 0.75

Articles cited by this

Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature (2007) 19.33

Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res (2004) 14.53

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87

Digital PCR. Proc Natl Acad Sci U S A (1999) 10.54

Nanostructures in biodiagnostics. Chem Rev (2005) 9.96

Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science (2003) 8.17

Microfluidic large-scale integration. Science (2002) 7.64

Systems biology and new technologies enable predictive and preventative medicine. Science (2004) 7.59

Chemistry and properties of nanocrystals of different shapes. Chem Rev (2005) 6.83

High gradient magnetic cell separation with MACS. Cytometry (1990) 6.69

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21

Electrochemical DNA sensors. Nat Biotechnol (2003) 4.80

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74

Requirements for high impact diagnostics in the developing world. Nature (2006) 4.73

Quantitation of targets for PCR by use of limiting dilution. Biotechniques (1992) 4.65

Array-based electrical detection of DNA with nanoparticle probes. Science (2002) 4.33

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 4.11

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol (2010) 4.04

Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med (2010) 3.90

Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One (2013) 3.53

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature (2012) 3.40

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A (2005) 3.15

Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proc Natl Acad Sci U S A (2007) 3.13

Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11

Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA. Proc Natl Acad Sci U S A (2003) 2.95

Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low- and middle-income countries. PLoS Med (2012) 2.84

Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med (2012) 2.82

Making it stick: convection, reaction and diffusion in surface-based biosensors. Nat Biotechnol (2008) 2.82

Disparities in cancer diagnosis and survival. Cancer (2001) 2.81

Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer. Cancer Discov (2012) 2.76

Point-of-care nucleic acid testing for infectious diseases. Trends Biotechnol (2011) 2.57

Detection limits for nanoscale biosensors. Nano Lett (2005) 2.42

Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy. Proc Natl Acad Sci U S A (2009) 2.33

The role radius of curvature plays in thiolated oligonucleotide loading on gold nanoparticles. ACS Nano (2009) 2.32

An ultrasensitive universal detector based on neutralizer displacement. Nat Chem (2012) 2.29

Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens. J Clin Microbiol (2006) 2.27

Studying copy number variations using a nanofluidic platform. Nucleic Acids Res (2008) 2.23

Quantitative real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution. J Am Chem Soc (2006) 2.22

The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med (2013) 2.18

Spherical nucleic acids. J Am Chem Soc (2012) 2.09

A decade of development in immunoassay methodology. Clin Chem (1990) 2.01

Metagenomics and personalized medicine. Cell (2011) 2.00

Megapixel digital PCR. Nat Methods (2011) 1.94

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets. Nat Chem (2011) 1.93

Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device. PLoS One (2012) 1.86

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology. Chem Rev (2013) 1.69

Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay. Leuk Lymphoma (2011) 1.61

Target-responsive structural switching for nucleic acid-based sensors. Acc Chem Res (2010) 1.61

Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load. J Am Chem Soc (2011) 1.51

Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy. Am J Obstet Gynecol (2009) 1.50

Digital PCR provides absolute quantitation of viral load for an occult RNA virus. J Virol Methods (2011) 1.50

Size-selective microcavity array for rapid and efficient detection of circulating tumor cells. Anal Chem (2010) 1.40

Programming the detection limits of biosensors through controlled nanostructuring. Nat Nanotechnol (2009) 1.32

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study. Resuscitation (2012) 1.31

Plasma tau levels in Alzheimer's disease. Alzheimers Res Ther (2013) 1.30

Electrochemical coding technology for simultaneous detection of multiple DNA targets. J Am Chem Soc (2003) 1.21

Direct profiling of cancer biomarkers in tumor tissue using a multiplexed nanostructured microelectrode integrated circuit. ACS Nano (2009) 1.19

Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano Lett (2006) 1.18

Deformability considerations in filtration of biological cells. Lab Chip (2010) 1.17

Multiplexed nanoflares: mRNA detection in live cells. Anal Chem (2012) 1.15

Digital readout of target binding with attomole detection limits via enzyme amplification in femtoliter arrays. J Am Chem Soc (2006) 1.13

A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing. Adv Mater (2010) 1.11

Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. J Am Chem Soc (2006) 1.11

Electrocatalytic detection of pathogenic DNA sequences and antibiotic resistance markers. Anal Chem (2003) 1.10

Molecular methods and platforms for infectious diseases testing a review of FDA-approved and cleared assays. J Mol Diagn (2011) 1.10

Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans. PLoS One (2011) 1.09

Digital LAMP in a sample self-digitization (SD) chip. Lab Chip (2012) 1.08

Chemistry. Miniature analytical methods for medical diagnostics. Science (2005) 1.08

Direct detection of bacterial genomic DNA at sub-femtomolar concentrations using single molecule arrays. Anal Chem (2013) 1.02

Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma. Brain Inj (2013) 1.01

Direct, electronic microRNA detection for the rapid determination of differential expression profiles. Angew Chem Int Ed Engl (2009) 1.00

The effect of rapid screening for methicillin-resistant Staphylococcus aureus (MRSA) on the identification and earlier isolation of MRSA-positive patients. Infect Control Hosp Epidemiol (2010) 0.99

Mechanistic evaluation of the pros and cons of digital RT-LAMP for HIV-1 viral load quantification on a microfluidic device and improved efficiency via a two-step digital protocol. Anal Chem (2013) 0.99

Polymerase chain reaction-free, sample-to-answer bacterial detection in 30 minutes with integrated cell lysis. Anal Chem (2011) 0.98

Solution-based circuits enable rapid and multiplexed pathogen detection. Nat Commun (2013) 0.97

Hierarchical nanotextured microelectrodes overcome the molecular transport barrier to achieve rapid, direct bacterial detection. ACS Nano (2011) 0.97

An automated high-throughput counting method for screening circulating tumor cells in peripheral blood. Anal Chem (2013) 0.96

Detection of HIV-1 p24 Gag in plasma by a nanoparticle-based bio-barcode-amplification method. Nanomedicine (Lond) (2008) 0.95

Organophosphonate-based PNA-functionalization of silicon nanowires for label-free DNA detection. ACS Nano (2008) 0.95

Increased robustness of single-molecule counting with microfluidics, digital isothermal amplification, and a mobile phone versus real-time kinetic measurements. Anal Chem (2013) 0.94

Nanostructuring of sensors determines the efficiency of biomolecular capture. Anal Chem (2010) 0.93

A Portable, Pressure Driven, Room Temperature Nucleic Acid Extraction and Storage System for Point of Care Molecular Diagnostics. Anal Methods (2013) 0.91

Direct genetic analysis of ten cancer cells: tuning sensor structure and molecular probe design for efficient mRNA capture. Angew Chem Int Ed Engl (2011) 0.90

Simple diffusion-constrained immunoassay for p24 protein with the sensitivity of nucleic acid amplification for detecting acute HIV infection. J Virol Methods (2012) 0.90

DNA nanostructure-decorated surfaces for enhanced aptamer-target binding and electrochemical cocaine sensors. Anal Chem (2011) 0.89

Detection of single-molecule DNA hybridization using enzymatic amplification in an array of femtoliter-sized reaction vessels. J Am Chem Soc (2008) 0.88

Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease. J Immunol Methods (2011) 0.87

DNA Nanostructure-based Interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA. Sci Rep (2012) 0.86

Clinical evaluation of a novel method for the measurement of prostate-specific antigen, AccuPSA(TM) , as a predictor of 5-year biochemical recurrence-free survival after radical prostatectomy: results of a pilot study. BJU Int (2011) 0.86

Hybridization chain reaction amplification of microRNA detection with a tetrahedral DNA nanostructure-based electrochemical biosensor. Anal Chem (2014) 0.86

A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells. Methods (2013) 0.83

Charge transport within a three-dimensional DNA nanostructure framework. J Am Chem Soc (2012) 0.83

Regenerable electrochemical immunological sensing at DNA nanostructure-decorated gold surfaces. Chem Commun (Camb) (2011) 0.82

Chip-based nanostructured sensors enable accurate identification and classification of circulating tumor cells in prostate cancer patient blood samples. Anal Chem (2012) 0.79

Efficient isolation and accurate in situ analysis of circulating tumor cells using detachable beads and a high-pore-density filter. Angew Chem Int Ed Engl (2013) 0.76