Published in PLoS One on May 20, 2010
Identifying targets for preventing epilepsy using systems biology. Neurosci Lett (2011) 1.07
MicroRNAs in the pathophysiology and treatment of status epilepticus. Front Mol Neurosci (2013) 0.91
Epileptogenesis. Cold Spring Harb Perspect Med (2015) 0.87
Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing. Sci Rep (2014) 0.85
Validation of suitable reference genes for expression studies in different pilocarpine-induced models of mesial temporal lobe epilepsy. PLoS One (2013) 0.82
Gene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis. PLoS One (2013) 0.82
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus. J Neuroinflammation (2011) 0.81
Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy. Eur J Neurosci (2013) 0.80
Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity. Toxicol Appl Pharmacol (2011) 0.78
Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning. Front Neurol (2015) 0.78
Transcriptomic Profiling of Medial Temporal Lobe Epilepsy. J Proteomics Bioinform (2012) 0.78
RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis. Sci Rep (2017) 0.78
Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons. Mol Neurobiol (2016) 0.75
The Effects of Kainic Acid-Induced Seizure on Gene Expression of Brain Neurotransmitter Receptors in Mice Using RT(2) PCR Array. Basic Clin Neurosci (2016) 0.75
Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. PLoS One (2016) 0.75
Astrocyte Reactivity Following Blast Exposure Involves Aberrant Histone Acetylation. Front Mol Neurosci (2016) 0.75
Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process. PLoS One (2017) 0.75
Systematic determination of genetic network architecture. Nat Genet (1999) 25.45
CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 5.22
Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci U S A (2000) 5.01
Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res (2000) 4.82
Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat Neurosci (1998) 4.65
IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol (2003) 4.64
Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med (1998) 4.16
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature (1999) 3.88
Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res (2000) 3.84
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience (1985) 3.53
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest (1985) 3.49
Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol (2002) 3.43
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21
The epidemiology of epilepsy revisited. Curr Opin Neurol (2003) 2.86
Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci (2004) 2.80
Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J Neurosci (2009) 2.53
Identification of a site in glutamate receptor subunits that controls calcium permeability. Science (1991) 2.53
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol (2002) 2.43
Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc Natl Acad Sci U S A (1997) 2.16
Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J Comp Neurol (2002) 2.08
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol (1997) 2.05
Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. J Neurosci (2000) 2.05
Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol (2001) 1.98
Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintainance of epilepsy. Pharmacol Ther (2004) 1.94
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J Pharmacol Exp Ther (2003) 1.93
Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci (2006) 1.88
Endocannabinoids facilitate the induction of LTP in the hippocampus. Nat Neurosci (2002) 1.84
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron (2003) 1.80
Cxc chemokine receptor expression on human endothelial cells. Cytokine (1999) 1.79
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus. J Neurosci (2005) 1.79
Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation. Neuroscience (1999) 1.77
Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience (1983) 1.75
Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci (2007) 1.69
Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia (2003) 1.60
Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances. Neurochem Res (2001) 1.60
Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J Comp Neurol (1989) 1.57
Susceptibility of immature and adult brains to seizure effects. Lancet Neurol (2004) 1.55
Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. Crit Rev Neurobiol (2006) 1.46
Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy Behav (2008) 1.44
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol (2000) 1.43
Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature (1978) 1.42
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. Neurobiol Dis (2003) 1.39
Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci (2002) 1.37
Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms. Neuroscience (2000) 1.37
Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth. J Neurosci (2003) 1.33
High-density microarray analysis of hippocampal gene expression following experimental brain injury. J Neurosci Res (2002) 1.32
Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus. Epilepsy Res (2000) 1.31
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. Epilepsia (2008) 1.28
p53 induction is associated with neuronal damage in the central nervous system. Proc Natl Acad Sci U S A (1994) 1.27
Sensitive indicators of injury reveal hippocampal damage in C57BL/6J mice treated with kainic acid in the absence of tonic-clonic seizures. Brain Res (2004) 1.26
S100 beta stimulates calcium fluxes in glial and neuronal cells. J Biol Chem (1992) 1.22
Resistance of the immature hippocampus to seizure-induced synaptic reorganization. Brain Res Dev Brain Res (1991) 1.21
Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling. Hippocampus (2001) 1.19
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy. J Neurosci Res (2006) 1.18
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy. Hippocampus (2003) 1.18
Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. Epilepsia (2005) 1.16
The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology (1996) 1.14
Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus. Brain Res Dev Brain Res (2002) 1.11
Human cystatin, a new protein inhibitor of cysteine proteinases. Biochem Biophys Res Commun (1984) 1.10
Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy. Hippocampus (2000) 1.08
Seizure-induced neuronal death in the immature brain. Prog Brain Res (2002) 1.08
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci (2003) 1.08
cDNA profiling of epileptogenesis in the rat brain. Eur J Neurosci (2003) 1.07
Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP-19, neurogranin, and neuromodulin. J Biol Chem (1996) 1.07
Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study. J Neurosci (1994) 1.07
Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8. Lab Invest (1997) 1.06
GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy. Neurochem Int (1999) 1.03
Electroconvulsive seizures induce angiogenesis in adult rat hippocampus. Biol Psychiatry (2005) 1.00
Gene profiling the response to kainic acid induced seizures. Brain Res Mol Brain Res (2005) 0.99
Microglial secreted cathepsin B induces neuronal apoptosis. J Neurochem (2001) 0.98
Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res (2008) 0.95
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J Neurochem (2000) 0.94
Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett (1995) 0.94
Expression of PEP-19 inhibits apoptosis in PC12 cells. Neuroreport (2000) 0.93
Hippocampal alterations of apolipoprotein E and D mRNA levels in vivo and in vitro following kainate excitotoxicity. Epilepsy Res (1999) 0.92
Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Neuroscience (2008) 0.92
The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs. J Neurochem (2001) 0.91
Calcium-binding proteins are concentrated in the CA2 field of the monkey hippocampus: a possible key to this region's resistance to epileptic damage. Exp Brain Res (1991) 0.91
Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model. Eur J Neurosci (2001) 0.91
Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy. Proc Natl Acad Sci U S A (1996) 0.91
Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration. Neurochem Int (2000) 0.89
Epileptogenesis causes an N-methyl-d-aspartate receptor/Ca2+-dependent decrease in Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent epileptiform discharges. Eur J Pharmacol (2008) 0.87
Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-D-aspartate receptor expression in the brain. Brain Res Dev Brain Res (2004) 0.87
Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy. Eur J Neurosci (2001) 0.87
Kainic acid-induced status epilepticus alters GABA receptor subunit mRNA and protein expression in the developing rat hippocampus. J Neurochem (2005) 0.86
Seizure-induced gene expression in area CA1 of the mouse hippocampus. Eur J Neurosci (2001) 0.86
Calcium binding protein containing neurons in the gliotic mouse hippocampus with special reference to their afferents from the medial septum and the entorhinal cortex. Neuroscience (2006) 0.86
Effect of apolipoprotein E deficiency on reactive sprouting in the dentate gyrus of the hippocampus following entorhinal cortex lesion: role of the astroglial response. Exp Neurol (2005) 0.86
Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures. Brain Res (1993) 0.86
Serial analysis of gene expression in the hippocampus of patients with mesial temporal lobe epilepsy. Neuroscience (2006) 0.85
Differential expression of S100beta and glial fibrillary acidic protein in the hippocampus after kainic acid-induced lesions and mossy fiber sprouting in adult rat. Exp Neurol (2000) 0.83
Systemic administration of kainic acid in adult rat stimulates expression of the chemokine receptor CCR5 in the forebrain. Glia (2002) 0.81
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures. Neurosci Lett (2007) 0.81
Differential expression and localization of the phosphorylated and nonphosphorylated neurofilaments during the early postnatal development of rat hippocampus. Hippocampus (2003) 0.80
Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus. Epilepsia (2007) 0.79
Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus. Neurobiol Dis (2004) 0.79
Protective effect of DY-9760e, a calmodulin antagonist, against neuronal cell death. Biol Pharm Bull (2004) 0.77
Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus. Int J Dev Neurosci (2006) 0.92
Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease. Eur J Nucl Med Mol Imaging (2012) 0.90
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy. Neurosci Lett (2003) 0.90
Maturation of cultured hippocampal slices results in increased excitability in granule cells. Int J Dev Neurosci (2005) 0.83
Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures. Epilepsia (2005) 0.82
AMPA/kainate receptor-mediated up-regulation of GABAA receptor delta subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation. Brain Res (2006) 0.81
Brain oscillatory EEG event-related desynchronization (ERD) and -sychronization (ERS) responses during an auditory memory task are altered in children with epilepsy. Seizure (2007) 0.81
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus. J Neuroinflammation (2011) 0.81
Meconium aspiration induces neuronal injury in piglets. Acta Paediatr (2005) 0.80
Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death. Neuropharmacology (2010) 0.79
Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus. Neurobiol Dis (2004) 0.79
Asphyxia aggravates systemic hypotension but not pulmonary hypertension in piglets with meconium aspiration. Pediatr Res (2003) 0.79
Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus. Epilepsia (2007) 0.79
Kainate down-regulates a subset of GABAA receptor subunits expressed in cultured mouse cerebellar granule cells. Cerebellum (2004) 0.78
Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets. Early Hum Dev (2006) 0.78
Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice. Epilepsy Res (2010) 0.78
Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system. J Neurosci (2006) 0.77
Meconium aspiration induces oxidative injury in the hippocampus of newborn piglets. Early Hum Dev (2005) 0.77
The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures. Eur J Neurosci (2006) 0.76
Histamine 1 receptor knock out mice show age-dependent susceptibility to status epilepticus and consequent neuronal damage. Epilepsy Res (2012) 0.75
Auditory event related potentials as tools to reveal cognitive late effects in childhood cancer patients. Clin Neurophysiol (2010) 0.75
Analysis of human neuropeptide FF gene expression. J Neurochem (2002) 0.75