Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention.

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Published in Rheum Dis Clin North Am on May 01, 2010

Authors

Sougata Karmakar1, Jonathan Kay, Ellen M Gravallese

Author Affiliations

1: Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Medical Center, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA 01605, USA.

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Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol (1992) 1.83

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IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol (1990) 1.77

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression. J Biol Chem (2006) 1.73

Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes. Arthritis Rheum (2006) 1.73

Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate. Arthritis Rheum (2008) 1.73

Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum (2002) 1.72

Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res (2009) 1.68

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer (2003) 1.65

The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum (1997) 1.60

The effect of a single dose of osteoprotegerin in postmenopausal women. J Bone Miner Res (2001) 1.57

Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis. Arthritis Rheum (2004) 1.53

The role of Wnt proteins in arthritis. Nat Clin Pract Rheumatol (2008) 1.52

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Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur Cytokine Netw (1996) 1.47

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Erratum to: Treating rheumatoid arthritis to target: an international initiative. Curr Rev Musculoskelet Med (2011) 0.75

Abortion: round 1. Commentary (1994) 0.75

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Treating rheumatoid arthritis to target: an international initiative. Curr Rev Musculoskelet Med (2011) 0.75

Evaluation of alert-based monitoring in a computerised blood transfusion management system. Stud Health Technol Inform (2011) 0.75

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Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: a diagnostic aid. J Am Acad Dermatol (2011) 0.75

New policy on disclosure of interest for American College of Rheumatology Journals. Arthritis Rheum (2003) 0.75

New policy on disclosure of interest for American College of Rheumatology journals. Arthritis Rheum (2003) 0.75