Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.

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Published in J Bone Miner Res on January 01, 1996

Authors

S Kotake1, K Sato, K J Kim, N Takahashi, N Udagawa, I Nakamura, A Yamaguchi, T Kishimoto, T Suda, S Kashiwazaki

Author Affiliations

1: Institute of Rheumatology, Tokyo Women's Medical College, Japan.

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Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06

Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene. Cell (1979) 5.04

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02

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Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40

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Interleukin-6 in biology and medicine. Adv Immunol (1993) 4.06

IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03

In vitro activity of DR-3355, an optically active ofloxacin. Antimicrob Agents Chemother (1988) 4.03

Infection with HIV is associated with elevated IL-6 levels and production. J Immunol (1990) 3.89

Isolation of human rotavirus in cell cultures: brief report. Arch Virol (1981) 3.83

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell (1982) 3.72

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Proc Natl Acad Sci U S A (1980) 3.70

Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J (1987) 3.64

Biochemical properties of beta-lactamase produced by Flavobacterium odoratum. Antimicrob Agents Chemother (1985) 3.62

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59

Defining the functions of trans-SNARE pairs. Nature (1998) 3.52

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci U S A (1985) 3.46

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity (2000) 3.45

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol (1998) 3.39

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Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki. N Engl J Med (1968) 3.29

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A role for hematopoietic stem cells in promoting angiogenesis. Cell (2000) 3.25

Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev (1997) 3.23

Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nat Genet (1994) 3.17

In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood (1992) 3.15

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science (1993) 3.13

IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol (2000) 3.08

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Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man. Proc Natl Acad Sci U S A (1983) 3.07