Published in ChemMedChem on July 05, 2010
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity. J Med Chem (2013) 0.88
Design, synthesis, and initial biological evaluation of a steroidal anti-estrogen-doxorubicin bioconjugate for targeting estrogen receptor-positive breast cancer cells. Bioconjug Chem (2012) 0.85
PROTAC-induced proteolytic targeting. Methods Mol Biol (2012) 0.75
Estrogen Receptor Ligands: A Review (2013-2015). Sci Pharm (2016) 0.75
Targeted Protein Degradation: from Chemical Biology to Drug Discovery. Cell Chem Biol (2017) 0.75
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell (1998) 9.96
Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer (2002) 4.57
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst (2003) 4.45
Protein translocation channels in the proteasome and other proteases. Cell (1997) 3.56
Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy. J Clin Oncol (1996) 2.83
Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene (2003) 2.82
Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev (2001) 2.54
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem (2001) 2.45
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet (1995) 2.45
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc Natl Acad Sci U S A (2001) 2.39
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environ Health Perspect (2003) 2.32
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J (1997) 2.29
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell (2004) 2.08
ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Cancer (2000) 2.05
Chemical genetic control of protein levels: selective in vivo targeted degradation. J Am Chem Soc (2004) 1.93
Selective estrogen receptor modulation: concept and consequences in cancer. Cancer Cell (2004) 1.92
Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl Cancer Inst (1995) 1.91
Peptide antagonists of the human estrogen receptor. Science (1999) 1.86
The estradiol pharmacophore: ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site. Steroids (1997) 1.80
Estrogen receptor and breast cancer. Semin Cancer Biol (2001) 1.77
Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br J Cancer (2004) 1.72
Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers. Biochem Biophys Res Commun (2001) 1.67
Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett (1999) 1.54
Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway. J Biol Chem (1995) 1.49
Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Res Treat (1993) 1.36
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res (2006) 1.35
Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene (2008) 1.17
Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'. Trends Cell Biol (2002) 1.10
Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett (1999) 1.08
Tamoxifen resistance in breast cancer: elucidating mechanisms. Drugs (2001) 1.08
Similarities and distinctions in the mode of action of different classes of antioestrogens. Endocr Relat Cancer (2000) 1.07
Pattern of hormone receptor status of secondary contralateral breast cancers in patients receiving adjuvant tamoxifen. Clin Cancer Res (2002) 1.00
Integrated "3+1" oxorhenium(V) complexes as estrogen mimics. Bioconjug Chem (1999) 0.98
Synthesis and evaluation of geldanamycin-testosterone hybrids. Bioorg Med Chem Lett (2000) 0.97
Degradation of target protein in living cells by small-molecule proteolysis inducer. Bioorg Med Chem Lett (2004) 0.97
Targeted degradation of the aryl hydrocarbon receptor by the PROTAC approach: a useful chemical genetic tool. Chembiochem (2007) 0.97
Antiestrogenic action of raloxifene and tamoxifen: today and tomorrow. J Natl Cancer Inst (1998) 0.95
The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations. Chem Biol (2001) 0.92
Synthesis and Binding Affinities of Novel Re-Containing 7alpha-Substituted Estradiol Complexes: Models for Breast Cancer Imaging Agents. J Org Chem (1999) 0.91
Synthesis of chimeric 7alpha-substituted estradiol derivatives linked to cholesterol and cholesterylamine. Org Lett (2002) 0.91
Is tamoxifen the Rosetta stone for breast cancer? J Natl Cancer Inst (2003) 0.88
Synthesis and evaluation of hexahydrochrysene and tetrahydrobenzofluorene ligands for the estrogen receptor. Bioorg Med Chem Lett (2001) 0.82
Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells. Br J Cancer (2001) 0.82
Regulatory mechanisms in breast cancer. Steroidal pure antiestrogens. Cancer Treat Res (1991) 0.80
The relationship between hormone receptor content and the effect of adjuvant tamoxifen in operable breast cancer. J Clin Oncol (1989) 0.80
Preparation, receptor binding, and fluorescence properties of hexestrol-fluorophore conjugates: evaluation of site of attachment, fluorophore structure, and fluorophore-ligand spacing. J Med Chem (1987) 0.79
Development of novel oestrogen-receptor antagonists. Biochem Soc Trans (1991) 0.77
Estrogen receptor binding tolerance of 16 alpha-substituted estradiol derivatives. Steroids (1989) 0.76
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol (2012) 2.14
Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis. Environ Health Perspect (2008) 1.86
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol (2013) 1.66
Analysis of the Arabidopsis nuclear proteome and its response to cold stress. Plant J (2003) 1.50
LMP2-specific inhibitors: chemical genetic tools for proteasome biology. Chem Biol (2007) 1.35
Healthy Twin: a twin-family study of Korea--protocols and current status. Twin Res Hum Genet (2006) 1.27
Ionothermal syntheses of six three-dimensional zinc metal-organic frameworks with 1-alkyl-3-methylimidazolium bromide ionic liquids as solvents. Inorg Chem (2007) 1.17
Overexpression of SOD in retina: need for increase in H2O2-detoxifying enzyme in same cellular compartment. Free Radic Biol Med (2011) 1.14
Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention. Mol Pharmacol (2008) 1.12
Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway . Biochemistry (2009) 1.07
Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA (2008) 1.02
Peptide/graphene hybrid assembly into core/shell nanowires. Adv Mater (2010) 1.02
Role of the xenobiotic receptor in inflammatory bowel disease. Inflamm Bowel Dis (2010) 1.00
Do we need more twin studies? The Healthy Twin Study, Korea. Int J Epidemiol (2006) 1.00
Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death. Cell Immunol (2002) 0.98
Targeted degradation of the aryl hydrocarbon receptor by the PROTAC approach: a useful chemical genetic tool. Chembiochem (2007) 0.97
Simple method for quantitative analysis of N-linked glycoproteins in hepatocellular carcinoma specimens. J Proteome Res (2010) 0.96
Catalposide, a compound isolated from catalpa ovata, attenuates induction of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonic Acid-induced colitis in mice. Inflamm Bowel Dis (2004) 0.95
Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations. J Phys Chem B (2010) 0.95
Induction and localization of NOD2 protein in human endothelial cells. Cell Immunol (2005) 0.95
Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-kappaB activity via direct interaction with p50. Mol Cancer Ther (2009) 0.93
Prevalence of Helicobacter hepaticus, murine norovirus, and Pneumocystis carinii and eradication efficacy of cross-fostering in genetically engineered mice. Exp Anim (2009) 0.92
Product control by halide ions of ionic liquids in the ionothermal syntheses of Ni-(H)BTC metal-organic frameworks. Chem Commun (Camb) (2009) 0.91
Selection of an antiviral RNA aptamer against hemagglutinin of the subtype H5 avian influenza virus. Nucleic Acid Ther (2011) 0.89
Significant association between IL-17F promoter region polymorphism and susceptibility to asthma in a Korean population. Int Arch Allergy Immunol (2010) 0.89
Polyelectrolyte brush amplified electroactuation of microcantilevers. Nano Lett (2008) 0.89
8-hydroxydeoxyguanosine causes death of human leukemia cells deficient in 8-oxoguanine glycosylase 1 activity by inducing apoptosis. Mol Cancer Res (2003) 0.88
Retracted Diabetic HDL-associated myristic acid inhibits acetylcholine-induced nitric oxide generation by preventing the association of endothelial nitric oxide synthase with calmodulin. Am J Physiol Cell Physiol (2007) 0.87
Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase. J Periodontal Res (2004) 0.86
Use of PROTACS as molecular probes of angiogenesis. Bioorg Med Chem Lett (2005) 0.86
Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor. Mol Pharmacol (2011) 0.86
Surface-associated material from Porphyromonas gingivalis stimulates the release of nitric oxide by inducing expression of inducible nitric oxide synthase. Microbes Infect (2005) 0.85
Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction. J Periodontol (2012) 0.85
Resonance Raman studies of xanthine oxidase: The reduced enzyme-product complex with violapterin. J Phys Chem B (2005) 0.85
Prevotella intermedia lipopolysaccharide stimulates release of tumor necrosis factor-alpha through mitogen-activated protein kinase signaling pathways in monocyte-derived macrophages. FEMS Immunol Med Microbiol (2007) 0.85
Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells. Chembiochem (2012) 0.85
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem (2014) 0.84
Iron chelator induces MIP-alpha/CCL20 in human intestinal epithelial cells: implication for triggering mucosal adaptive immunity. Exp Mol Med (2005) 0.84
Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines. Free Radic Biol Med (2002) 0.84
In vitro evidence for the recognition of 8-oxoGTP by Ras, a small GTP-binding protein. Biochem Biophys Res Commun (2005) 0.84
Impact of linker length on the activity of PROTACs. Mol Biosyst (2010) 0.83
A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes. Bioorg Med Chem (2011) 0.83
Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway. Mol Biosyst (2012) 0.83
Iron chelator induces THP-1 cell differentiation potentially by modulating intracellular glutathione levels. Free Radic Biol Med (2006) 0.83
Increased expression of MIP-3alpha/CCL20 in peripheral blood mononuclear cells from patients with ulcerative colitis and its down-regulation by sulfasalazine and glucocorticoid treatment. Inflamm Bowel Dis (2005) 0.83
An adult case of internal mammary arterio-venous fistula. Korean Circ J (2011) 0.82
Induction of growth phase-specific autolysis in Bacillus subtilis 168 by growth inhibitors. J Microbiol (2009) 0.81
Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA. Biochem J (2005) 0.81
Nitric oxide production and inducible nitric oxide synthase expression induced by Prevotella nigrescens lipopolysaccharide. FEMS Immunol Med Microbiol (2005) 0.81
Axillary approach versus the infraclavicular approach in ultrasound-guided brachial plexus block: comparison of anesthetic time. Korean J Anesthesiol (2011) 0.81
An evaluation of the time for nursing activity in a hospital using a full Electronic Medical Record System (EMR). Stud Health Technol Inform (2006) 0.81
Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model. Cell Immunol (2009) 0.80
A FRET-based approach for identification of proteasome catalytic subunit composition. Mol Biosyst (2014) 0.79
Regulating charge injection in ambipolar organic field-effect transistors by mixed self-assembled monolayers. ACS Appl Mater Interfaces (2014) 0.78
Combination effects of cation and anion of ionic liquids on the cadmium metal-organic frameworks in ionothermal systems. Inorg Chem (2008) 0.77
Photodynamic therapy for breast cancer in a BALB/c mouse model. J Gynecol Oncol (2012) 0.77
SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms. Bioorg Med Chem Lett (2006) 0.77
Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2. Biochem J (2012) 0.77
Reversible electrochemical switching of polyelectrolyte brush surface energy using electroactive counterions. Langmuir (2008) 0.77
Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. ACS Chem Neurosci (2013) 0.76
Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death. Free Radic Biol Med (2004) 0.76
Elucidating the catalytic subunit composition of distinct proteasome subtypes: a crosslinking approach employing bifunctional activity-based probes. Chembiochem (2014) 0.75
PROTAC-induced proteolytic targeting. Methods Mol Biol (2012) 0.75
Mutation of the lbp-5 gene alters metabolic output in Caenorhabditis elegans. BMB Rep (2014) 0.75
Impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cutaneous wound healing. Exp Toxicol Pathol (2011) 0.75
Influence of phenolic hydroxyl groups on second-order optical nonlinearity at an example of 2,4- and 3,4-dihydroxyl hydrazone isomorphic crystals. J Chem Phys (2009) 0.75
Purification and characterization of a new anticoagulant protein, PP27, from placenta. Thromb Res (2005) 0.75
Effect of FGF-2 on collagen tissue regeneration by human vertebral bone marrow stem cells. Stem Cells Dev (2015) 0.75
Manganese Oxides Nanoparticle as New P-type Dopant for High Performance Polymer Field-Effect Transistors. ACS Appl Mater Interfaces (2017) 0.75
Palliation using a self-expandable stent in a patient with obstructive right-ventricular outflow tract after total correction of tetralogy of Fallot: self-expandable stent in tetralogy of Fallot. Pediatr Cardiol (2012) 0.75