Published in Infect Immun on June 01, 2010
Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells. Cell Microbiol (2011) 0.87
Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis. PLoS One (2013) 0.86
Shiga toxins: intracellular trafficking to the ER leading to activation of host cell stress responses. Toxins (Basel) (2010) 0.80
Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death. Infect Immun (2015) 0.79
Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications. Toxins (Basel) (2016) 0.78
Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel) (2017) 0.75
Food-related illness and death in the United States. Emerg Infect Dis (1999) 39.22
Apoptosis: a review of programmed cell death. Toxicol Pathol (2007) 17.92
Death receptors: signaling and modulation. Science (1998) 16.95
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell (1998) 16.08
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol (1992) 11.24
Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity (1995) 10.59
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet (2005) 9.78
Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities. Infect Immun (1986) 8.09
Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun (1991) 6.25
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem (1996) 6.22
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur J Biochem (1988) 5.22
The role of BH3-only proteins in the immune system. Nat Rev Immunol (2005) 4.69
Apoptotic pathways: paper wraps stone blunts scissors. Cell (2000) 4.37
Overview of cell death signaling pathways. Cancer Biol Ther (2005) 4.22
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem (2004) 3.70
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity (2000) 3.45
Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice. Infect Immun (1993) 3.36
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity (1997) 2.60
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem (1997) 2.26
Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ (2004) 2.17
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution. Nat Struct Biol (1994) 2.15
Shiga toxin, Shiga-like toxin II variant, and ricin are all single-site RNA N-glycosidases of 28 S RNA when microinjected into Xenopus oocytes. J Biol Chem (1989) 2.12
Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J Biol Chem (2000) 1.77
X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res (2004) 1.77
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem (2002) 1.65
Staying alive: bacterial inhibition of apoptosis during infection. Trends Microbiol (2008) 1.61
Defining and assaying RNAi in mammalian cells. Mol Cell (2005) 1.60
Modulation of phagocyte apoptosis by bacterial pathogens. Apoptosis (2004) 1.59
Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines. Infect Immun (1996) 1.56
Shiga toxins. Toxicon (2001) 1.54
FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. J Biol Chem (2000) 1.51
Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells. Cell Microbiol (2007) 1.49
TRAIL as a target in anti-cancer therapy. Cancer Lett (2009) 1.39
Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood (1992) 1.39
A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry (2000) 1.34
Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death Differ (1998) 1.31
Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. Am J Pathol (1999) 1.27
Shiga toxins and apoptosis. FEMS Microbiol Lett (2003) 1.27
Caspase-8 in cancer biology and therapy. Cancer Lett (2008) 1.26
Rapid apoptosis induced by Shiga toxin in HeLa cells. Infect Immun (2003) 1.23
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage. Eur J Immunol (1998) 1.19
Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells. Cancer Res (2000) 1.19
Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha. J Leukoc Biol (2002) 1.18
TRAIL resistance results in cancer progression: a TRAIL to perdition? Oncogene (2006) 1.17
Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases. Infect Immun (2002) 1.17
Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP. Mol Cell Biol (2003) 1.17
Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene. Biochem Biophys Res Commun (2000) 1.14
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines. Apoptosis (2002) 1.11
Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism. Infect Immun (2005) 1.09
Characterization of non-toxic mutant toxins of Vero toxin 1 that were constructed by replacing amino acids in the A subunit. Microb Pathog (1993) 1.07
Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochem Biophys Res Commun (2001) 1.06
Death receptors as targets of cancer therapeutics. Curr Cancer Drug Targets (2004) 1.02
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway. Oncogene (2002) 0.98
Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infect Immun (2006) 0.97
Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts. Toxicology (2007) 0.97
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling. J Thorac Oncol (2007) 0.96
Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells. Microb Pathog (2005) 0.95
Shiga toxin receptor glycolipid binding. Pathology and utility. Methods Mol Med (2003) 0.95
Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway. Infect Immun (2009) 0.92
TRAIL-induced apoptosis: between tumor therapy and immunopathology. Ann N Y Acad Sci (2009) 0.91
Shiga-like toxin inhibition of FLICE-like inhibitory protein expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis. J Biol Chem (2002) 0.91
15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. Mol Cancer Ther (2008) 0.90
The treatment of malignant meningioma with verotoxin. Neoplasia (2002) 0.90
Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis. BMC Cancer (2009) 0.88
Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells. Infect Immun (2009) 0.87
Response to Shiga toxin 1 and 2 in a baboon model of hemolytic uremic syndrome. Pediatr Nephrol (2003) 1.67
Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells. Cell Microbiol (2007) 1.49
Shiga toxins and apoptosis. FEMS Microbiol Lett (2003) 1.27
Regulation of proinflammatory cytokine expression by Shiga toxin 1 and/or lipopolysaccharides in the human monocytic cell line THP-1. Infect Immun (2004) 1.19
Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha. J Leukoc Biol (2002) 1.18
Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase, CD45. J Biol Chem (2003) 1.11
Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli. Infect Immun (2010) 1.10
Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism. Infect Immun (2005) 1.09
Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line. J Leukoc Biol (2005) 1.08
Lipopolysaccharide-induced apoptosis of endothelial cells and its inhibition by vascular endothelial growth factor. J Immunol (2002) 1.05
Chemokine expression in the monocytic cell line THP-1 in response to purified shiga toxin 1 and/or lipopolysaccharides. Infect Immun (2005) 1.00
Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infect Immun (2006) 0.97
Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells. Microb Pathog (2005) 0.95
CXCR4/CCR5 down-modulation and chemotaxis are regulated by the proteasome pathway. J Biol Chem (2002) 0.94
Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway. Infect Immun (2009) 0.92
Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment. Transl Gastrointest Cancer (2012) 0.91
Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. PLoS One (2012) 0.91
Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2. Infect Immun (2011) 0.91
Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells. Infect Immun (2009) 0.87
Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. Am J Pathol (2013) 0.87
Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells. Cell Microbiol (2011) 0.87
Regulation of cytokine and chemokine expression by the ribotoxic stress response elicited by Shiga toxin type 1 in human macrophage-like THP-1 cells. Infect Immun (2012) 0.86
Global transcriptional response of macrophage-like THP-1 cells to Shiga toxin type 1. Infect Immun (2010) 0.86
Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. Infect Immun (2010) 0.83
Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events. Lab Invest (2012) 0.82
The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome. Am J Nephrol (2005) 0.81
Shiga toxins: intracellular trafficking to the ER leading to activation of host cell stress responses. Toxins (Basel) (2010) 0.80
von Willebrand Factor expression in a Shiga toxin-mediated primate model of hemolytic uremic syndrome. Pediatr Dev Pathol (2002) 0.79
Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells. J Microbiol (2013) 0.79
Prophylactic heparinization is ineffective in a primate model of hemolytic uremic syndrome. Pediatr Nephrol (2002) 0.78
Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatr Res (2006) 0.77
Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms. Am J Physiol Gastrointest Liver Physiol (2013) 0.77
Renal prostacyclin biosynthesis in a baboon model of Shiga toxin mediated hemolytic uremic syndrome. Nephron (2002) 0.77
Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS). Ren Fail (2005) 0.77