The intratracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate.

PubWeight™: 2.30‹?› | Rank: Top 2%

🔗 View Article (PMC 1886409)

Published in Am J Pathol on June 01, 1991

Authors

T R Ulich1, L R Watson, S M Yin, K Z Guo, P Wang, H Thang, J del Castillo

Author Affiliations

1: Department of Pathology, University of California Irvine School of Medicine 92717.

Articles citing this

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med (2005) 6.37

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest (1998) 4.77

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest (2009) 2.96

Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect Immun (1997) 2.54

Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice. Infect Immun (1998) 2.20

Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun (2005) 1.99

Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. J Clin Invest (1994) 1.88

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol (1998) 1.82

Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation. Am J Pathol (1992) 1.65

Gene expression and production of tumor necrosis factor alpha, interleukin 1, interleukin 6, and gamma interferon in C3H/HeN and C57BL/6N mice in acute Mycoplasma pulmonis disease. Infect Immun (1995) 1.50

Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49

Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol (2007) 1.43

An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med (2011) 1.40

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. J Clin Invest (1996) 1.38

Streptococcal cysteine protease augments lung injury induced by products of group A streptococci. Infect Immun (1996) 1.25

Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue. Am J Pathol (1993) 1.20

Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infect Immun (2004) 1.13

Simplified high throughput protocol for northern hybridization. Nucleic Acids Res (1993) 1.11

Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung. Br J Pharmacol (1996) 1.10

Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers. J Allergy Clin Immunol (2012) 1.09

Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury. Inflammation (1998) 1.06

Role of p38 MAP kinase in LPS-induced airway inflammation in the rat. Br J Pharmacol (2001) 1.06

Intratracheal administration of endotoxin and cytokines. IV. The soluble tumor necrosis factor receptor type I inhibits acute inflammation. Am J Pathol (1993) 1.03

Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue. Immunology (2003) 1.03

Cytokines. 2. Cytokines and lung inflammation: mechanisms of neutrophil recruitment to the lung. Thorax (1993) 1.03

Endotoxin-induced cytokine gene expression in vivo. IV. Expression of interleukin-1 alpha/beta and interleukin-1 receptor antagonist mRNA during endotoxemia and during endotoxin-initiated local acute inflammation. Am J Pathol (1992) 1.00

Endotoxin, interleukin-1, and tumor necrosis factor cause neutrophil-dependent microvascular leakage in postcapillary venules. Am J Pathol (1992) 1.00

Inflammatory bronchopulmonary response of preterm infants with microbial colonisation of the airways at birth. Arch Dis Child Fetal Neonatal Ed (1996) 1.00

Vagal afferents modulate cytokine-mediated respiratory control at the neonatal medulla oblongata. Respir Physiol Neurobiol (2011) 0.97

The pulmonary inflammatory response to experimental fecal peritonitis: relative roles of tumor necrosis factor-alpha and endotoxin. Inflammation (1997) 0.96

Apoptotic response of Chang cells to infection with Pseudomonas aeruginosa strains PAK and PAO-I: molecular ordering of the apoptosis signaling cascade and role of type IV pili. Infect Immun (2003) 0.96

Dynamic changes in inflammatory cytokines in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Clin Vaccine Immunol (2010) 0.93

Implications of polyadenylation in health and disease. Nucleus (2014) 0.92

The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation. Shock (2007) 0.92

Interaction between porcine reproductive-respiratory syndrome virus and bacterial endotoxin in the lungs of pigs: potentiation of cytokine production and respiratory disease. J Clin Microbiol (2003) 0.92

Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation (2000) 0.91

Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.90

Experimental extrinsic allergic alveolitis and pulmonary angiitis induced by intratracheal or intravenous challenge with Corynebacterium parvum in sensitized rats. Am J Pathol (1996) 0.87

Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling. Physiol Genomics (2009) 0.87

Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases. Environ Health Prev Med (2010) 0.85

The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice. PPAR Res (2012) 0.83

Protective effects of aerobic exercise on acute lung injury induced by LPS in mice. Crit Care (2012) 0.83

Low-level laser therapy (LLLT) acts as cAMP-elevating agent in acute respiratory distress syndrome. Lasers Med Sci (2010) 0.81

LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha. Immunology (1995) 0.81

Lead increases lipopolysaccharide-induced liver-injury through tumor necrosis factor-alpha overexpression by monocytes/macrophages: role of protein kinase C and P42/44 mitogen-activated protein kinase. Environ Health Perspect (2006) 0.77

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages. PLoS Comput Biol (2016) 0.75

Suppression of pulmonary injury in experimental 'Goodpasture's syndrome' by deoxyspergualin (DSP). Clin Exp Immunol (1994) 0.75

Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.75

Inhaled nitric oxide alleviates hyperoxia suppressed phosphatidylcholine synthesis in endotoxin-induced injury in mature rat lungs. Respir Res (2006) 0.75

Inhibitor κBα protein therapy alleviates severe pneumonia through inhibition of nuclear factor κB. Exp Ther Med (2017) 0.75

DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS One (2015) 0.75

Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions. Br J Pharmacol (1996) 0.75

In vivo dexamethasone effects on neutrophil effector functions in a rat model of acute lung injury. Inflammation (1997) 0.75

The atypical response regulator AtvR is a new player in Pseudomonas aeruginosa response to hypoxia and virulence. Infect Immun (2017) 0.75

Articles cited by this

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science (1985) 19.41

Shock and tissue injury induced by recombinant human cachectin. Science (1986) 16.24

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A (1986) 15.20

Interleukin-1. Rev Infect Dis (1984) 11.24

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med (1986) 10.91

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature (1985) 9.81

Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (1986) 9.19

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest (1988) 5.22

Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science (1989) 4.99

Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Nature (1986) 4.98

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci U S A (1988) 3.04

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice. J Exp Med (1988) 2.92

Acute inflammation and microthrombosis induced by endotoxin, interleukin-1, and tumor necrosis factor and their implication in gram-negative infection. Lab Invest (1988) 2.77

In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse. J Clin Invest (1986) 2.22

Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J Clin Invest (1989) 2.13

Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol (1987) 2.08

Synergy between tumour necrosis factor alpha and interleukin-1 in the induction of polymorphonuclear leukocyte migration during inflammation. J Leukoc Biol (1988) 1.92

Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response. J Infect Dis (1989) 1.87

The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin. Am J Pathol (1986) 1.70

Production and clearance of tumor necrosis factor in rats exposed to endotoxin and dexamethasone. Clin Immunol Immunopathol (1987) 1.64

Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor. J Immunol (1988) 1.61

In vivo dynamics of murine tumor necrosis factor-alpha gene expression. Kinetics of dexamethasone-induced suppression. Lab Invest (1989) 1.60

Northern and Southern blots. Methods Enzymol (1987) 1.47

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. Am J Pathol (1990) 1.46

Differential production of tumor necrosis factor, macrophage colony stimulating factor, and interleukin 1 by human alveolar macrophages. J Leukoc Biol (1989) 1.37

Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines. Cancer Res (1988) 1.21

Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats. J Immunol (1988) 1.19

Interleukin 1-induced pathophysiology: induction of cytokines, development of histopathologic changes, and immunopharmacologic intervention. Clin Immunol Immunopathol (1989) 1.11

Evidence that tumour necrosis factor (TNF) is not constitutively present in vivo. The association of TNF with freshly isolated monocytes reflects a rapid in vitro production. Scand J Immunol (1988) 1.06

IL-1 secretion by macrophages. Enhancement of IL-1 secretion and processing by calcium ionophores. J Immunol (1990) 1.04

Hematologic interactions of endotoxin, tumor necrosis factor alpha (TNF alpha), interleukin 1, and adrenal hormones and the hematologic effects of TNF alpha in Corynebacterium parvum-primed rats. J Leukoc Biol (1989) 1.03

Mechanisms of tumor necrosis factor alpha-induced lymphopenia, neutropenia, and biphasic neutrophilia: a study of lymphocyte recirculation and hematologic interactions of TNF alpha with endogenous mediators of leukocyte trafficking. J Leukoc Biol (1989) 0.98

Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes. Evidence against a membrane form of IL-1. J Immunol (1990) 0.95

Cyclosporine A inhibits TNF production without decreasing TNF mRNA levels. Biochem Biophys Res Commun (1989) 0.93

Mechanisms of tumor necrosis factor-alpha alteration of PMN adhesion and migration. Am J Pathol (1990) 0.93

Failure of tumor necrosis factor to produce hypotensive shock in the absence of endotoxin. Surgery (1989) 0.88

Acute in vivo effects of IL-3 alone and in combination with IL-6 on the blood cells of the circulation and bone marrow. Am J Pathol (1989) 0.84

Cytokine- and calcium ionophore A23187-mediated arachidonic acid metabolism in neutrophils. Cytokine (1990) 0.83

The hematopoietic activities of interleukin-1. Biotherapy (1989) 0.82

Characterization of the pulmonary inflammatory response to an anaerobic bacterial challenge. Am Rev Respir Dis (1986) 0.82

An overview on interleukin-1 as a therapeutic agent. Biotherapy (1989) 0.81

Functional studies of bovine alveolar neutrophils elicited with recombinant bovine IL-1 beta. J Immunol (1990) 0.79

Articles by these authors

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell (2000) 7.82

Experience with a mixed semantic/syntactic parser. Proc Annu Symp Comput Appl Med Care (1995) 5.61

Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev (2000) 5.49

Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill (2013) 4.37

Enzyme-independent formation of nitric oxide in biological tissues. Nat Med (1995) 4.28

CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus. J Mol Biol (1989) 3.56

A natural language understanding system combining syntactic and semantic techniques. Proc Annu Symp Comput Appl Med Care (1994) 3.42

Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37

Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem (1994) 3.34

Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill (2013) 2.99

Diagnosing syncope. Part 2: Unexplained syncope. Clinical Efficacy Assessment Project of the American College of Physicians. Ann Intern Med (1997) 2.96

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J (1998) 2.94

Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol (2001) 2.91

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene (2008) 2.83

p53 domains: identification and characterization of two autonomous DNA-binding regions. Genes Dev (1993) 2.74

Risk factors for osteonecrosis in systemic lupus erythematosus. J Rheumatol (1997) 2.59

The Philadelphia story: the 22q11.2 deletion: report on 250 patients. Genet Couns (1999) 2.58

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol (1994) 2.57

Diagnosing syncope. Part 1: Value of history, physical examination, and electrocardiography. Clinical Efficacy Assessment Project of the American College of Physicians. Ann Intern Med (1997) 2.36

Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab (1996) 2.33

Cyclin A1 is required for meiosis in the male mouse. Nat Genet (1998) 2.28

Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Oncogene (2006) 2.14

An updatable holographic three-dimensional display. Nature (2008) 2.14

Paracrine actions of growth differentiation factor-9 in the mammalian ovary. Mol Endocrinol (1999) 2.08

Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol (1987) 2.08

Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction. Biochemistry (1999) 2.04

Depression in the workplace: effects on short-term disability. Health Aff (Millwood) (1999) 2.01

Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. J Gen Physiol (1997) 1.99

A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source. Phys Med Biol (2009) 1.97

Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proc Natl Acad Sci U S A (2000) 1.96

Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices. Circulation (2001) 1.91

Biomechanical evaluation of four different posterior atlantoaxial fixation techniques. Spine (Phila Pa 1976) (1992) 1.89

Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am J Pathol (1991) 1.82

Isolation of influenza C virus from pigs and experimental infection of pigs with influenza C virus. J Gen Virol (1983) 1.81

Treatment of attacks in hyperkalaemic familial periodic paralysis by inhalation of salbutamol. Lancet (1976) 1.77

The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics (1999) 1.75

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J Clin Invest (1997) 1.74

Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6. J Immunol (1991) 1.74

Detection of 16 gamma-ray pulsars through blind frequency searches using the Fermi LAT. Science (2009) 1.74

Dominant inheritance of optic pits. Am J Ophthalmol (1997) 1.74

The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol (1998) 1.72

Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Euro Surveill (2014) 1.69

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. Oncogene (2007) 1.68

In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood (1989) 1.68

Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans (2007) 1.67

Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med (2000) 1.66

Seismostratigraphy and thermal structure of Earth's core-mantle boundary region. Science (2007) 1.66

Holographic three-dimensional telepresence using large-area photorefractive polymer. Nature (2010) 1.64

Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol Endocrinol (1999) 1.64

Adrenal insufficiency during the late stage of polymicrobial sepsis. Crit Care Med (2001) 1.63

Prenatal sonographic characteristics and Doppler blood flow study in a case of a large fetal mediastinal teratoma. Ultrasound Obstet Gynecol (1998) 1.62

Strain dynamics of ultrathin VO₂ film grown on TiO₂ (001) and the associated phase transition modulation. Nano Lett (2014) 1.61

Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res (2001) 1.60

Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance. J Nucl Med (1994) 1.59

The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. Am J Pathol (1991) 1.58

Development of retinoblastoma in the absence of telomerase activity. J Natl Cancer Inst (1996) 1.57

p53 oligomerization and DNA looping are linked with transcriptional activation. EMBO J (1994) 1.57

Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol (2001) 1.56

Resistance to activated protein C and Legg-Perthes disease. Clin Orthop Relat Res (1997) 1.55

Modulated high-energy gamma-ray emission from the microquasar Cygnus X-3. Science (2009) 1.55

Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility. Am J Physiol (1999) 1.55

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci U S A (1995) 1.52

Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage. Am J Physiol (1991) 1.52

Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol (2001) 1.52

Cardiac contractility and structure are not significantly compromised even during the late, hypodynamic stage of sepsis. Shock (1998) 1.52

A preliminary pilot study of treatment of thrombophilia and hypofibrinolysis and amelioration of the pain of osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1998) 1.52

Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res (1999) 1.49

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis. J Cell Biol (2001) 1.48

The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins. Ann Surg (1991) 1.48

Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem (1995) 1.48

Early clinical response as a predictor of subsequent response to ixekizumab treatment: results from a phase II study of patients with moderate-to-severe plaque psoriasis. Br J Dermatol (2013) 1.47

Observations on the action of type A botulinum toxin on frog neuromuscular junctions. J Physiol (1974) 1.46

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. Am J Pathol (1990) 1.46

Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk. Genet Mol Res (2011) 1.45

Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril (2001) 1.43

Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrob Agents Chemother (2000) 1.42

Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock. Crit Care Med (1998) 1.41

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol (2009) 1.40

A cocoon of freshly accelerated cosmic rays detected by Fermi in the Cygnus superbubble. Science (2011) 1.39

The Fermi Gamma-Ray Space Telescope discovers the pulsar in the young galactic supernova remnant CTA 1. Science (2008) 1.39

Clinical value of renovascular resistive index measurement in the diagnosis of acute obstructive uropathy. J Urol (1997) 1.39

Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA. Biochem J (1997) 1.39

Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review). Int J Mol Med (1999) 1.39

Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. Kidney Int (2007) 1.38

Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res (1999) 1.38

Appendicular adenocarcinoma. Ann Surg (1995) 1.38

Human ultrasonic speech perception. Science (1991) 1.38

Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol (1997) 1.38

A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase. Comp Biochem Physiol B (1974) 1.38

Anatomical correlates of early mutism in progressive nonfluent aphasia. Neurology (2006) 1.36

Potential metabolite markers of schizophrenia. Mol Psychiatry (2011) 1.35

Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis. Clin Orthop Relat Res (1997) 1.34

Mapping the spin-density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging. J Magn Reson B (1995) 1.34

Spin-torque influence on the high-frequency magnetization fluctuations in magnetic tunnel junctions. Phys Rev Lett (2007) 1.33

Determinants of glaucoma awareness in a general eye clinic. Ophthalmology (2000) 1.33