CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.

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Published in J Clin Invest on September 21, 2009

Authors

Franco R D'Alessio1, Kenji Tsushima, Neil R Aggarwal, Erin E West, Matthew H Willett, Martin F Britos, Matthew R Pipeling, Roy G Brower, Rubin M Tuder, John F McDyer, Landon S King

Author Affiliations

1: Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA.

Associated clinical trials:

Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial (DART) | NCT04482621

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Interactive effects of mechanical ventilation and kidney health on lung function in an in vivo mouse model. Am J Physiol Lung Cell Mol Physiol (2008) 1.59

Higher PEEP in patients with acute lung injury: a systematic review and meta-analysis. Respir Care (2011) 1.59

HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med (2006) 1.58

Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. Am J Respir Cell Mol Biol (2005) 1.56

Impaired lung homeostasis in neonatal mice exposed to cigarette smoke. Am J Respir Cell Mol Biol (2007) 1.56

Lung size mismatch and survival after single and bilateral lung transplantation. Ann Thorac Surg (2013) 1.54

Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol (2005) 1.54

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest (2010) 1.53

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med (2011) 1.52

T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis. J Immunol (2008) 1.52

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.51

Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.50

Emphysema lung tissue gene expression profiling. Am J Respir Cell Mol Biol (2004) 1.49

Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials. Crit Care (2009) 1.49

Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol (2014) 1.45

CT virtual bronchoscopy of the central airways in patients with Wegener's granulomatosis. Chest (2002) 1.45

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem (2008) 1.44

Usefulness of bronchoscopic microsampling to detect the pathogenic bacteria of respiratory infection. Chest (2007) 1.42

Potential benefits of early continuous positive pressure ventilation in patients with rapidly progressive interstitial pneumonia. Respirology (2012) 1.42

Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol (2006) 1.42

Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A (2002) 1.41

Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41

Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes. Chest (2012) 1.41

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. Am J Physiol Lung Cell Mol Physiol (2009) 1.40