Published in Obesity (Silver Spring) on June 10, 2010
Genomic imprinting and parent-of-origin effects on complex traits. Nat Rev Genet (2013) 1.40
Fine-mapping alleles for body weight in LG/J × SM/J F₂ and F(34) advanced intercross lines. Mamm Genome (2011) 1.05
Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. PLoS Genet (2011) 1.05
Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. J Exp Zool B Mol Dev Evol (2011) 0.94
Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross. Mamm Genome (2010) 0.92
Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. J Lipid Res (2010) 0.91
The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice. BMC Genomics (2014) 0.90
Dark matter: are mice the solution to missing heritability? Front Genet (2011) 0.90
The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model. Mamm Genome (2011) 0.87
Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice. Physiol Genomics (2012) 0.86
Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics (2013) 0.85
Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists. Biol Sex Differ (2011) 0.84
Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice. Front Genet (2011) 0.84
Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides. BMC Genomics (2015) 0.81
Weak genetic relationship between trabecular bone morphology and obesity in mice. Bone (2012) 0.78
Fine-mapping QTLs in advanced intercross lines and other outbred populations. Mamm Genome (2014) 0.77
Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice. J Orthop Res (2015) 0.77
Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. PeerJ (2014) 0.75
A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity (Edinb) (1992) 55.23
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
Environmental epigenomics and disease susceptibility. Nat Rev Genet (2007) 11.02
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb) (2005) 9.85
Advanced intercross lines, an experimental population for fine genetic mapping. Genetics (1995) 5.69
Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr (2009) 3.56
The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Trends Genet (2003) 2.99
Genome-wide prediction of imprinted murine genes. Genome Res (2005) 2.76
Quantitative trait loci for murine growth. Genetics (1996) 2.71
Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet (2006) 2.60
Efficient inference of haplotypes from genotypes on a pedigree. J Bioinform Comput Biol (2003) 1.89
Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice. Mamm Genome (2001) 1.74
Relaxed significance criteria for linkage analysis. Genetics (2006) 1.70
Genome-wide analysis reveals a complex pattern of genomic imprinting in mice. PLoS Genet (2008) 1.63
Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet (2005) 1.54
Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight. Evolution (2007) 1.47
Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes (2001) 1.44
Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration. J Exp Zool B Mol Dev Evol (2004) 1.44
Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatr Res (2007) 1.41
Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes (2004) 1.38
Genomic imprinting effects on adult body composition in mice. Proc Natl Acad Sci U S A (2008) 1.31
Sex dependent imprinting effects on complex traits in mice. BMC Evol Biol (2008) 1.22
Mapping and exclusion mapping of genomic imprinting effects in mouse F2 families. J Hered (2005) 1.22
Genetic linkage and imprinting effects on body mass index in children and young adults. Eur J Hum Genet (2003) 1.21
Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity (Silver Spring) (2008) 1.20
ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity (Silver Spring) (2008) 1.15
Missing heritability and GWAS utility. Obesity (Silver Spring) (2009) 1.15
How large is the energy gap that accounts for the obesity epidemic? Am J Clin Nutr (2009) 1.13
Diet, obesity, and hyperglycemia in LG/J and SM/J mice. Obes Res (2003) 1.03
Genetic variation and correlation of dietary response in an advanced intercross mouse line produced from two divergent growth lines. Genet Res (2005) 1.02
Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line. Obesity (Silver Spring) (2009) 1.02
Relative contribution of additive, dominance, and imprinting effects to phenotypic variation in body size and growth between divergent selection lines of mice. Evolution (2008) 0.99
Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes (2004) 0.94
Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. Adv Exp Med Biol (2008) 0.90
A paternally imprinted QTL for mature body mass on mouse chromosome 8. Mamm Genome (2005) 0.89
Obesity--still highly heritable after all these years. Am J Clin Nutr (2008) 0.87
Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. Am J Clin Nutr (2009) 0.84
Detecting parent of origin and dominant QTL in a two-generation commercial poultry pedigree using variance component methodology. Genet Sel Evol (2009) 0.82
Differential response to dietary fat in large (LG/J) and small (SM/J) inbred mouse strains. Physiol Genomics (1999) 0.82
A framework for detecting and characterizing genetic background-dependent imprinting effects. Mamm Genome (2009) 0.82
The Amber biomolecular simulation programs. J Comput Chem (2005) 28.84
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A (2007) 9.71
Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol (2005) 5.27
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab (2005) 3.86
Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release (2006) 3.85
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev (2003) 3.53
The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs. Hum Genomics (2004) 3.53
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell (2009) 3.26
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation (2003) 3.22
Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler Thromb Vasc Biol (2002) 3.01
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care (2004) 3.00
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature (2012) 2.54
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50
Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature (2008) 2.50
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature (2004) 2.39
Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS Genet (2011) 2.35
Multilevel selection 2: Estimating the genetic parameters determining inheritance and response to selection. Genetics (2006) 2.31
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature (2002) 2.26
Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A (2010) 2.16
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab (2005) 2.14
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell (2006) 2.13
Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther (2008) 2.07
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol Ther (2011) 2.04
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet (2005) 2.04
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Interacting phenotypes and the evolutionary process. III. Social evolution. Evolution (2010) 2.02
Controlling the Kondo effect of an adsorbed magnetic ion through its chemical bonding. Science (2005) 1.98
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med (2003) 1.94
Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting. Genetics (2008) 1.88
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol (2010) 1.86
Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release (2007) 1.79
Finding cis-regulatory elements using comparative genomics: some lessons from ENCODE data. Genome Res (2007) 1.75
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. J Neurosci (2007) 1.74
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet (2006) 1.73
Exploring long-range genome interactions using the WashU Epigenome Browser. Nat Methods (2013) 1.71
Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature (2005) 1.68
Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice. Hum Gene Ther (2008) 1.65
Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model. Spine J (2011) 1.63
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell (2005) 1.62
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med (2010) 1.62
Microporous and photoluminescent chalcogenide zeolite analogs. Science (2002) 1.61
Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice. Hum Gene Ther (2002) 1.56
Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs. Mol Ther (2010) 1.56
Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metab (2012) 1.54
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest (2008) 1.51
Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.51
Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse. Hypertension (2007) 1.50
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2009) 1.47
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin Cancer Res (2013) 1.47
Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease. PLoS One (2013) 1.47
Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight. Evolution (2007) 1.47
Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes (2005) 1.47
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J (2006) 1.45
Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration. J Exp Zool B Mol Dev Evol (2004) 1.44
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Retracted Investigation of the hub genes and related mechanism in ovarian cancer via bioinformatics analysis. J Ovarian Res (2013) 1.42
Atomic structure, energetics, and dynamics of topological solitons in indium chains on Si(111) surfaces. Phys Rev Lett (2011) 1.42
Imputation of single-nucleotide polymorphisms in inbred mice using local phylogeny. Genetics (2012) 1.42
Genomic imprinting and parent-of-origin effects on complex traits. Nat Rev Genet (2013) 1.40
Why we should put clothes on mice. Cell Metab (2009) 1.40
Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab (2007) 1.38
Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes (2004) 1.38
Genetic tools for studying adaptation and the evolution of behavior. Am Nat (2002) 1.38
Structural Survey of Zinc Containing Proteins and the Development of the Zinc AMBER Force Field (ZAFF). J Chem Theory Comput (2010) 1.37
Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance. J Exp Zool B Mol Dev Evol (2003) 1.36
Quantitative trait loci for body size components in mice. Mamm Genome (2006) 1.35
Quantitative trait loci for maternal performance for offspring survival in mice. Genetics (2002) 1.33
Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology (2008) 1.32
Formal Estimation of Errors in Computed Absolute Interaction Energies of Protein-ligand Complexes. J Chem Theory Comput (2011) 1.32
Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res (2005) 1.32
Genomic imprinting effects on adult body composition in mice. Proc Natl Acad Sci U S A (2008) 1.31
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One (2012) 1.29
Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials (2009) 1.29
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. J Chromatogr A (2011) 1.28
Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome (2006) 1.28
Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol (2009) 1.28
Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? Biochim Biophys Acta (2011) 1.27
Prediction of protein-protein interactions from amino acid sequences with ensemble extreme learning machines and principal component analysis. BMC Bioinformatics (2013) 1.26
Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice. J Bone Miner Res (2008) 1.26
Transparency tools in gene patenting for informing policy and practice. Nat Biotechnol (2013) 1.26
The immediate environment during postnatal development has long-term impact on gut community structure in pigs. ISME J (2008) 1.25