Published in Nature on May 26, 2005
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
Insulin resistance and atherosclerosis. J Clin Invest (2006) 2.27
Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia (2007) 1.94
Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem J (2006) 1.47
p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content. Circ Res (2009) 1.39
Aerobic metabolism underlies complexity and capacity. J Physiol (2007) 1.28
TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol (2009) 1.24
Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging (Albany NY) (2012) 1.24
IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ (2008) 1.12
Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab (2013) 1.12
Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci (2011) 1.11
Adventures in vascular biology: a tale of two mediators. Philos Trans R Soc Lond B Biol Sci (2006) 1.10
Insulin resistance and atherosclerosis. Endocrinol Metab Clin North Am (2008) 1.10
Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One (2013) 1.05
Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration. Am J Physiol Cell Physiol (2008) 1.04
Renal oxidative stress, oxygenation, and hypertension. Am J Physiol Regul Integr Comp Physiol (2011) 1.02
The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis. Mutat Res (2007) 1.00
Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. PLoS One (2011) 1.00
The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest (2011) 0.99
The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci (2009) 0.97
Increased protein nitration in mitochondrial diseases: evidence for vessel wall involvement. Mol Cell Proteomics (2010) 0.97
Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J Lipid Res (2008) 0.90
Oxidative stress, antioxidants, and vascular damage. Br J Clin Pharmacol (2006) 0.89
Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats. Hypertension (2012) 0.89
Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes. World J Cardiol (2012) 0.88
Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus. J Virol (2011) 0.88
Study on qi deficiency syndrome identification modes of coronary heart disease based on metabolomic biomarkers. Evid Based Complement Alternat Med (2014) 0.86
Protective effect of the ultra-filtration extract from Xin Mai Jia on human aortic smooth muscle cell injury induced by hydrogen peroxide. Exp Ther Med (2013) 0.85
Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature (2014) 0.85
Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury. Circulation (2008) 0.85
Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. Mol Cells (2013) 0.85
The tRNAMet 4435A>G mutation in the mitochondrial haplogroup G2a1 is responsible for maternally inherited hypertension in a Chinese pedigree. Eur J Hum Genet (2011) 0.84
Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol (2014) 0.83
Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids. Biochim Biophys Acta (2009) 0.83
Metabolomic analyses for atherosclerosis, diabetes, and obesity. Biomark Res (2013) 0.83
A defect in Δ6 and Δ5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians. Lipids Health Dis (2010) 0.83
Association of UCP1 genetic polymorphisms with blood pressure among Korean female subjects. J Korean Med Sci (2008) 0.80
A previously functional tetracycline-regulated transactivator fails to target gene expression to the bone. BMC Res Notes (2011) 0.79
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. J Nutr (2014) 0.78
Interleukins and atherosclerosis: a dysfunctional family grows. Cell Metab (2013) 0.78
Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin. PLoS One (2015) 0.77
The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees. Eur J Hum Genet (2012) 0.76
Relationship between sirtuin and mitochondrial uncoupling protein genes and carotid artery stiffness. Transl Res (2014) 0.76
Gene Expression in Experimental Aortic Coarctation and Repair: Candidate Genes for Therapeutic Intervention? PLoS One (2015) 0.76
Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. Am J Physiol Endocrinol Metab (2016) 0.75
Low levels of the reverse transactivator fail to induce target transgene expression in vascular smooth muscle cells. PLoS One (2014) 0.75
A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition. Physiol Rep (2017) 0.75
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A (2007) 9.71
Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol (2007) 4.30
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab (2005) 3.86
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell (2009) 3.26
Paternal race is a risk factor for preterm birth. Am J Obstet Gynecol (2007) 3.24
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation (2003) 3.22
Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler Thromb Vasc Biol (2002) 3.01
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care (2004) 3.00
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology (2004) 2.62
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe (2010) 2.57
Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol (2007) 2.56
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature (2012) 2.54
Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics (2014) 2.37
1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation (2009) 2.36
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development (2002) 2.31
Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis (2004) 2.24
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab (2005) 2.14
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci U S A (2004) 2.11
Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol (2005) 2.06
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci U S A (2006) 1.96
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med (2003) 1.94
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol (2008) 1.93
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis (2002) 1.92
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci (2005) 1.87
Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease. Circ Res (2007) 1.83
Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood (2013) 1.80
Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron (2002) 1.79
Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol (2005) 1.68
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci U S A (2006) 1.63
The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development. Am J Respir Cell Mol Biol (2003) 1.62
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry (2010) 1.59
Forebrain glucocorticoid receptors modulate anxiety-associated locomotor activation and adrenal responsiveness. J Neurosci (2006) 1.56
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med (2003) 1.55
Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Cell Metab (2012) 1.54
Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J Biol Chem (2002) 1.53
Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res (2009) 1.51
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. J Clin Invest (2008) 1.51
Genetic contributions to preterm birth: implications from epidemiological and genetic association studies. Ann Med (2008) 1.51
Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse. Hypertension (2007) 1.50
Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem (2012) 1.50
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood (2007) 1.48
Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol (2006) 1.47
Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity. Diabetes (2005) 1.47
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab (2008) 1.45
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning. Proc Natl Acad Sci U S A (2008) 1.41
Microarray analysis of uterine gene expression in mouse and human pregnancy. Mol Endocrinol (2003) 1.41
A proteomic approach for the discovery of protease substrates. Proc Natl Acad Sci U S A (2004) 1.40
Why we should put clothes on mice. Cell Metab (2009) 1.40
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci U S A (2008) 1.39
Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab (2007) 1.38
Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes (2004) 1.38
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res (2005) 1.37
Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology (2008) 1.32
Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease. PLoS One (2011) 1.32
Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Mol Cell Proteomics (2005) 1.32
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. Proc Natl Acad Sci U S A (2005) 1.31
Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. J Neurosci (2005) 1.28
A short interpregnancy interval is a risk factor for preterm birth and its recurrence. Am J Obstet Gynecol (2007) 1.27
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? Biochim Biophys Acta (2011) 1.27
Heritability of parturition timing: an extended twin design analysis. Am J Obstet Gynecol (2008) 1.26
Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. J Biol Chem (2008) 1.26
Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. FASEB J (2003) 1.24
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J Exp Med (2005) 1.22
Type 8 adenylyl cyclase is targeted to excitatory synapses and required for mossy fiber long-term potentiation. J Neurosci (2003) 1.22
Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS. Mol Cell Proteomics (2010) 1.22
A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nat Chem Biol (2013) 1.21
Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J Biol Chem (2007) 1.21
Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium. Cancer Discov (2013) 1.20
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy. Clin Chem (2005) 1.20
Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency. Hepatology (2004) 1.18