Published in FEBS Lett on June 11, 2010
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Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas. Mod Pathol (2015) 0.80
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TERT promoter mutations and prognosis in solitary fibrous tumor. Mod Pathol (2016) 0.80
The telomere protein tankyrase 1 regulates DNA damage responses at telomeres. Aging (Albany NY) (2010) 0.79
Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity. Eukaryot Cell (2011) 0.79
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Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma. Mod Pathol (2016) 0.77
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Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Rep (2016) 0.76
Visualization and quantitative analysis of extrachromosomal telomere-repeat DNA in individual human cells by Halo-FISH. Nucleic Acids Res (2015) 0.76
Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer. Pharmgenomics Pers Med (2015) 0.75
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TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies. Sci Rep (2016) 0.75
Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma. J Pathol Clin Res (2015) 0.75
Alternative lengthening of telomeres in primary pancreatic neuroendocrine neoplasms is associated with aggressive clinical behavior and poor survival. Clin Cancer Res (2016) 0.75
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Inter-telomeric recombination is present in telomerase-positive human cells. Cell Cycle (2013) 0.75
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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nat Biotechnol (2009) 2.35
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08
Alternative lengthening of telomeres is characterized by high rates of telomeric exchange. Cancer Res (2004) 1.99
A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clin Cancer Res (2005) 1.95
The first molecular details of ALT in human tumor cells. Hum Mol Genet (2005) 1.93
Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J (2009) 1.85
Telomere uncapping and alternative lengthening of telomeres. Mech Ageing Dev (2007) 1.68
Human POT1 facilitates telomere elongation by telomerase. Curr Biol (2003) 1.64
Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res (2009) 1.55
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology (2009) 1.55
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem (2007) 1.55
Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep (2011) 1.45
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Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. Mol Cell Biol (2005) 1.44
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer (2006) 1.42
Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies. Cancer Res (2005) 1.35
DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA. Cancer Res (2007) 1.34
Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival. J Neuropathol Exp Neurol (2010) 1.32
Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nat Genet (2002) 1.31
Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res (2002) 1.29
Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci (2008) 1.28
Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Hum Mol Genet (2009) 1.20
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One (2011) 1.20
A sensitive direct human telomerase activity assay. Nat Methods (2008) 1.19
Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Res (2002) 1.18
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Normal mammalian cells negatively regulate telomere length by telomere trimming. Hum Mol Genet (2011) 1.16
Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res (2007) 1.15
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit. Oncogene (2002) 1.07
hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Res (2005) 1.06
Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Res (2006) 1.05
Alternative lengthening of telomeres in normal mammalian somatic cells. Genes Dev (2013) 1.04
Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres. PLoS One (2012) 1.04
Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clin Cancer Res (2008) 1.02
STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Res (2012) 1.02
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J Cell Biol (2012) 1.02
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. J Cell Biol (2009) 1.01
Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres. Hum Mol Genet (2008) 1.01
Cancer. Cancer and telomeres--an ALTernative to telomerase. Science (2012) 1.00
Alternative lengthening of telomeres: remodeling the telomere architecture. Front Oncol (2013) 1.00
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem (2002) 1.00
MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res (2011) 0.99
The murine stanniocalcin 1 gene is not essential for growth and development. Mol Cell Biol (2005) 0.98
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology (2008) 0.98
PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res (2008) 0.98
The role of telomere trimming in normal telomere length dynamics. Cell Cycle (2012) 0.94
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Enhanced isolation of fibroblasts from human skin explants. Biotechniques (2012) 0.86
Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo. Cancer Res (2002) 0.86
HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PLoS One (2011) 0.86
Telomerase activity in pleural malignant mesotheliomas. Lung Cancer (2011) 0.86
Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels. Cancer Res (2008) 0.84
Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome. Hum Mol Genet (2005) 0.83
STC1 expression is associated with tumor growth and metastasis in breast cancer. Clin Exp Metastasis (2014) 0.82
Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res (2013) 0.80
A major functional difference between the mouse and human ARF tumor suppressor proteins. J Biol Chem (2002) 0.80
Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One (2012) 0.79
Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1). J Cell Sci (2009) 0.78
A SUMO ligase for ALT. Nat Struct Mol Biol (2007) 0.76
Molecular markers and long-term survivors of glioblastoma multiforme. Cancer J (2004) 0.75
Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours. Nature (2017) 0.75