Published in PLoS One on June 11, 2010
Analysis of the unexplored features of rrs (16S rDNA) of the Genus Clostridium. BMC Genomics (2011) 1.60
Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements. BMC Genomics (2011) 1.34
Toxin plasmids of Clostridium perfringens. Microbiol Mol Biol Rev (2013) 1.07
Characterization of toxin plasmids in Clostridium perfringens type C isolates. Infect Immun (2010) 1.05
Plasmidome interchange between Clostridium botulinum, Clostridium novyi and Clostridium haemolyticum converts strains of independent lineages into distinctly different pathogens. PLoS One (2014) 0.95
FSL J1-208, a virulent uncommon phylogenetic lineage IV Listeria monocytogenes strain with a small chromosome size and a putative virulence plasmid carrying internalin-like genes. Appl Environ Microbiol (2012) 0.95
Horizontal gene transfer of toxin genes in Clostridium botulinum: Involvement of mobile elements and plasmids. Mob Genet Elements (2011) 0.93
Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis. Mob DNA (2014) 0.91
Implications of Genome-Based Discrimination between Clostridium botulinum Group I and Clostridium sporogenes Strains for Bacterial Taxonomy. Appl Environ Microbiol (2015) 0.88
Identification of novel linear megaplasmids carrying a ß-lactamase gene in neurotoxigenic Clostridium butyricum type E strains. PLoS One (2011) 0.85
Plasmid-borne type E neurotoxin gene clusters in Clostridium botulinum strains. Appl Environ Microbiol (2013) 0.84
Three classes of plasmid (47-63 kb) carry the type B neurotoxin gene cluster of group II Clostridium botulinum. Genome Biol Evol (2014) 0.84
Clostridium botulinum strains producing BoNT/F4 or BoNT/F5. Appl Environ Microbiol (2014) 0.84
Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain. mSphere (2016) 0.79
Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts. Genome Biol Evol (2016) 0.77
Construction of Nontoxigenic Mutants of Nonproteolytic Clostridium botulinum NCTC 11219 by Insertional Mutagenesis and Gene Replacement. Appl Environ Microbiol (2016) 0.75
Mauve: multiple alignment of conserved genomic sequence with rearrangements. Genome Res (2004) 28.63
Neurotoxins affecting neuroexocytosis. Physiol Rev (2000) 5.42
Toxigenic clostridia. Clin Microbiol Rev (1990) 5.40
Genetic diversity among Botulinum Neurotoxin-producing clostridial strains. J Bacteriol (2006) 4.75
The ClosTron: a universal gene knock-out system for the genus Clostridium. J Microbiol Methods (2007) 4.20
The ClosTron: Mutagenesis in Clostridium refined and streamlined. J Microbiol Methods (2009) 3.16
Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect Immun (2005) 3.06
Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes. Genome Res (2007) 2.67
Conjugal transfer and characterization of bacteriocin plasmids in group N (lactic acid) streptococci. J Bacteriol (1984) 2.63
Characterization of the 'unusual' mobility of large circular DNAs in pulsed field-gradient electrophoresis. Nucleic Acids Res (1988) 2.58
Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum. BMC Genomics (2009) 2.50
Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. PLoS One (2007) 2.28
Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and F and Clostridium butyricum type E strains. BMC Biol (2009) 2.24
Biology and genomic analysis of Clostridium botulinum. Adv Microb Physiol (2009) 2.24
Outgrowth and toxin production of nonproteolytic type B Clostridium botulinum at 3.3 to 5.6 C. J Bacteriol (1967) 2.18
The enteric toxins of Clostridium perfringens. Rev Physiol Biochem Pharmacol (2004) 1.99
Novel Clostridium botulinum toxin gene arrangement with subtype A5 and partial subtype B3 botulinum neurotoxin genes. J Clin Microbiol (2009) 1.77
Enterotoxin plasmid from Clostridium perfringens is conjugative. Infect Immun (2001) 1.76
Identification of a transferable tetracycline resistance plasmid (pCW3) from Clostridium perfringens. Plasmid (1978) 1.68
A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol (2006) 1.59
Phylogenetic analysis of Clostridium botulinum type A by multi-locus sequence typing. Microbiology (2008) 1.52
Plasmid encoded neurotoxin genes in Clostridium botulinum serotype A subtypes. Biochem Biophys Res Commun (2007) 1.52
Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens. J Bacteriol (2006) 1.39
Genetic analysis of type E botulinum toxin-producing Clostridium butyricum strains. Appl Environ Microbiol (2000) 1.32
Evidence that plasmid-borne botulinum neurotoxin type B genes are widespread among Clostridium botulinum serotype B strains. PLoS One (2009) 1.31
Virulence plasmid diversity in Clostridium perfringens type D isolates. Infect Immun (2007) 1.30
Regulation of neurotoxin complex expression in Clostridium botulinum strains 62A, Hall A-hyper, and NCTC 2916. Anaerobe (2004) 1.30
The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny. Proc Natl Acad Sci U S A (2005) 1.28
Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. J Clin Microbiol (2009) 1.21
Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J Clin Microbiol (2005) 1.18
The genes for the Clostridium botulinum type G toxin complex are on a plasmid. Infect Immun (1995) 1.16
Epsilon-toxin plasmids of Clostridium perfringens type D are conjugative. J Bacteriol (2007) 1.16
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. J Clin Microbiol (1981) 1.15
Cloning, nucleotide sequence, and expression of the gene encoding the bacteriocin boticin B from Clostridium botulinum strain 213B. Appl Environ Microbiol (2000) 0.95
Transposon Tn916 mutagenesis in Clostridium botulinum. Appl Environ Microbiol (1991) 0.84
Characterization of neurotoxin mutants in Clostridium botulinum type A. Clin Infect Dis (1997) 0.80
Conditions for conjugative transposon transfer in Lactococcus lactis. Lett Appl Microbiol (2000) 0.78
Rapid SNP discovery and genetic mapping using sequenced RAD markers. PLoS One (2008) 13.64
Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags. PLoS Genet (2010) 7.05
The Group Health medical home at year two: cost savings, higher patient satisfaction, and less burnout for providers. Health Aff (Millwood) (2010) 6.60
Rapid and cost-effective polymorphism identification and genotyping using restriction site associated DNA (RAD) markers. Genome Res (2006) 5.80
SV2 is the protein receptor for botulinum neurotoxin A. Science (2006) 4.51
Construction and application for QTL analysis of a Restriction Site Associated DNA (RAD) linkage map in barley. BMC Genomics (2011) 3.42
Single-cell microbiology: tools, technologies, and applications. Microbiol Mol Biol Rev (2004) 2.53
RAD marker microarrays enable rapid mapping of zebrafish mutations. Genome Biol (2007) 2.07
Local de novo assembly of RAD paired-end contigs using short sequencing reads. PLoS One (2011) 1.98
Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature (2006) 1.97
SNP discovery and genotyping for evolutionary genetics using RAD sequencing. Methods Mol Biol (2011) 1.96
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A (2007) 1.85
Neurotoxin gene clusters in Clostridium botulinum type A strains: sequence comparison and evolutionary implications. Curr Microbiol (2003) 1.83
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J Cell Biol (2003) 1.81
High-density detection of restriction-site-associated DNA markers for rapid mapping of mutated loci in Neurospora. Genetics (2007) 1.78
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Mol Biol Cell (2008) 1.66
Analysis of neurotoxin cluster genes in Clostridium botulinum strains producing botulinum neurotoxin serotype A subtypes. Appl Environ Microbiol (2008) 1.62
A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol (2006) 1.59
Phylogenetic analysis of Clostridium botulinum type A by multi-locus sequence typing. Microbiology (2008) 1.52
Plasmid encoded neurotoxin genes in Clostridium botulinum serotype A subtypes. Biochem Biophys Res Commun (2007) 1.52
Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. Antimicrob Agents Chemother (2003) 1.47
The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability. Protein Expr Purif (2004) 1.45
Genetic homogeneity of Clostridium botulinum type A1 strains with unique toxin gene clusters. Appl Environ Microbiol (2008) 1.44
A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies. FEBS Lett (2007) 1.40
Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proc Natl Acad Sci U S A (2004) 1.40
Subunit vaccine against the seven serotypes of botulism. Infect Immun (2007) 1.39
Regulation of neurotoxin complex expression in Clostridium botulinum strains 62A, Hall A-hyper, and NCTC 2916. Anaerobe (2004) 1.30
Bleeding stomal varices: case series and systematic review of the literature. Clin Gastroenterol Hepatol (2008) 1.29
Safety of using a computerized rounding and sign-out system to reduce resident duty hours. Acad Med (2010) 1.29
Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum. J Bacteriol (2002) 1.28
Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc Natl Acad Sci U S A (2009) 1.26
Nucleotide sequence and transcriptional analysis of the type A2 neurotoxin gene cluster in Clostridium botulinum. FEMS Microbiol Lett (2004) 1.25
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog (2011) 1.24
Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination. J Pharmacol Toxicol Methods (2010) 1.21
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection. Toxicol Sci (2012) 1.21
Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J Clin Microbiol (2005) 1.18
Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology (2008) 1.16
Secular trends in colon and rectal cancer relative survival. J Natl Cancer Inst (2013) 1.16
SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog (2010) 1.15
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. J Cell Biol (2007) 1.15
Spreading a medical home redesign: effects on emergency department use and hospital admissions. Ann Fam Med (2013) 1.15
A survey of new temperature-sensitive, embryonic-lethal mutations in C. elegans: 24 alleles of thirteen genes. PLoS One (2011) 1.15
Amyloidosis presenting as lower gastrointestinal hemorrhage. WMJ (2008) 1.11
Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E. Infect Immun (2005) 1.10
Characterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro. Infect Immun (2013) 1.10
Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex. Appl Environ Microbiol (2009) 1.09
Recombinant holotoxoid vaccine against botulism. Infect Immun (2007) 1.09
Genomic patterns of introgression in rainbow and westslope cutthroat trout illuminated by overlapping paired-end RAD sequencing. Mol Ecol (2013) 1.09
Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Proc Natl Acad Sci U S A (2009) 1.09
Identification and function of hypoxia-response genes in Drosophila melanogaster. Physiol Genomics (2006) 1.07
Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett (2010) 1.07
Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. Cell Host Microbe (2011) 1.06
Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis (2004) 1.04
Obtaining informed consent for genetic studies: The multiethnic study of atherosclerosis. Am J Epidemiol (2006) 1.04
Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem (2006) 1.02
Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222. Appl Environ Microbiol (2011) 1.02
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun (2013) 0.99
Catalytic properties of botulinum neurotoxin subtypes A3 and A4. Biochemistry (2009) 0.99
Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol (2009) 0.97
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci (2012) 0.96
Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension). Analyst (2012) 0.95
Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists. FEBS Lett (2002) 0.93
Epitope characterization and variable region sequence of f1-40, a high-affinity monoclonal antibody to botulinum neurotoxin type a (Hall strain). PLoS One (2009) 0.93
Impact on seniors of the patient-centered medical home: evidence from a pilot study. Gerontologist (2012) 0.93
Lipid diversity among botulinum neurotoxin-producing clostridia. Microbiology (2012) 0.92
Characterization of the epitope region of F1-2 and F1-5, two monoclonal antibodies to Botulinum neurotoxin type A. Hybridoma (Larchmt) (2009) 0.91
Outcomes among chronically ill adults in a medical home prototype. Am J Manag Care (2013) 0.91
Construction of a nontoxigenic Clostridium botulinum strain for food challenge studies. Appl Environ Microbiol (2009) 0.91
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. Bioorg Med Chem Lett (2009) 0.90
Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells. Biochem Biophys Res Commun (2010) 0.90
Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Dev Biol (2012) 0.90
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C. Eur J Neurosci (2007) 0.89
Recent advances in crustacean genomics. Integr Comp Biol (2008) 0.88
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorg Med Chem (2012) 0.88
Massively parallel characterization of restriction endonucleases. Nucleic Acids Res (2013) 0.87
Rapid immune responses to a botulinum neurotoxin Hc subunit vaccine through in vivo targeting to antigen-presenting cells. Infect Immun (2011) 0.87
Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A. Biochem Biophys Res Commun (2011) 0.87
Stimulation of astaxanthin formation in the yeast Xanthophyllomyces dendrorhous by the fungus Epicoccum nigrum. FEMS Yeast Res (2004) 0.86
Validity of botulinum neurotoxin serotype H. J Infect Dis (2014) 0.86
Association of toxin-producing Clostridium botulinum with the macroalga Cladophora in the Great Lakes. Environ Sci Technol (2013) 0.86
Targeting botulinum A cellular toxicity: a prodrug approach. J Med Chem (2013) 0.86
Purification and characterization of a novel subtype a3 botulinum neurotoxin. Appl Environ Microbiol (2012) 0.85
Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. Biochemistry (2012) 0.85
Predictors of malignancy and recommended follow-up in patients with negative endoscopic ultrasound-guided fine-needle aspiration of suspected pancreatic lesions. Can J Gastroenterol (2009) 0.85
Design and evaluation of 16S rRNA-targeted peptide nucleic acid probes for whole-cell detection of members of the genus Listeria. Appl Environ Microbiol (2005) 0.85
Clostridium botulinum strains producing BoNT/F4 or BoNT/F5. Appl Environ Microbiol (2014) 0.84
Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity. Chem Commun (Camb) (2015) 0.83
Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorg Med Chem (2008) 0.83
Entry of a recombinant, full-length, atoxic tetanus neurotoxin into Neuro-2a cells. Infect Immun (2013) 0.83
Symptomatic hibernoma: a rare soft tissue tumor. Hawaii J Med Public Health (2012) 0.82
Partial protection against Botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity. Chembiochem (2005) 0.82