Published in Fundam Appl Toxicol on February 01, 1991
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene. EMBO J (1992) 3.92
The peroxisome: still a mysterious organelle. Histochem Cell Biol (2008) 1.41
Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol (2004) 1.35
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. Carcinogenesis (2005) 1.24
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem J (1995) 1.22
Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. Comp Hepatol (2003) 0.97
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. Toxicol Sci (2009) 0.90
Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. Environ Health Perspect (2008) 0.89
Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J Cell Biol (1994) 0.86
Crocetin improves the insulin resistance induced by high-fat diet in rats. Br J Pharmacol (2008) 0.82
Comparison of the hepatic effects of nafenopin and WY-14,643 on peroxisome proliferation and cell replication in the rat and Syrian hamster. Environ Health Perspect (1993) 0.79
Hazard identification: efficiency of short-term tests in identifying germ cell mutagens and putative nongenotoxic carcinogens. Environ Health Perspect (1993) 0.75
The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status. Int J Exp Pathol (2013) 0.75
Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A (1996) 4.66
Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci U S A (1995) 3.89
A critical review of the literature on hydrogen sulfide toxicity. Crit Rev Toxicol (1984) 3.57
Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature (1980) 2.85
Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem (1993) 2.81
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc Natl Acad Sci U S A (1986) 2.57
Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate. Science (1975) 2.35
Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit Rev Toxicol (1983) 2.18
Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem (2000) 2.14
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem (1997) 2.10
Activation of flavin-containing oxidases underlies light-induced production of H2O2 in mammalian cells. Proc Natl Acad Sci U S A (1999) 2.00
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice. Cancer Res (1994) 1.69
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase. Proc Natl Acad Sci U S A (1992) 1.68
Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem (1998) 1.60
Ductal metaplasia of human exocrine pancreas and its association with carcinoma. Cancer Res (1985) 1.57
Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A (1999) 1.54
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
Identification of toxicologically predictive gene sets using cDNA microarrays. Mol Pharmacol (2001) 1.52
Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem (1996) 1.51
Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells. Am J Pathol (2001) 1.48
A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. Regul Toxicol Pharmacol (1999) 1.47
Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell Biochem Biophys (2000) 1.45
Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J Biol Chem (2000) 1.42
Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. Gene Expr (1996) 1.42
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc Natl Acad Sci U S A (1999) 1.39
Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem (2000) 1.39
Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res (2000) 1.39
Hepatic and renal effects of peroxisome proliferators: biological implications. Ann N Y Acad Sci (1982) 1.36
Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas. Am J Pathol (1994) 1.35
Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator. Cancer Res (1989) 1.30
Comparative morphometry of the nasal cavity in rats and mice. J Anat (1982) 1.27
Pancreatic adenocarcinoma in inbred guinea pigs induced by n-methyl-N-nitrosourea. Cancer Res (1975) 1.26
Properties of purified carnitine acyltransferases of mouse liver peroxisomes. J Biol Chem (1984) 1.26
Hepatocellular carcinomas in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator. Cancer Res (1976) 1.25
A critical review of the literature on carbon disulfide toxicity. Crit Rev Toxicol (1983) 1.24
Dinitrotoluene: acute toxicity, oncogenicity, genotoxicity, and metabolism. Crit Rev Toxicol (1984) 1.21
Nafenopin-induced hepatic microbody (peroxisome) proliferation and catalase synthesis in rats and mice. Absence of sex difference in response. J Cell Biol (1974) 1.21
Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis (1987) 1.20
Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver. Hum Toxicol (1983) 1.20
Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat. Cancer Res (1988) 1.20
Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compounds. Toxicol Appl Pharmacol (1978) 1.20
Peroxisomal beta-oxidation and steatohepatitis. Semin Liver Dis (2001) 1.20
Peroxisomes (microbodies) in cell pathology. Int Rev Exp Pathol (1984) 1.20
Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A (2001) 1.19
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res (2001) 1.18
Studies on the testicular effects and zinc excretion produced by various isomers of monobutyl-o-phthalate in the rat. Chem Biol Interact (1981) 1.17
Almost total conversion of pancreas to liver in the adult rat: a reliable model to study transdifferentiation. Biochem Biophys Res Commun (1988) 1.16
Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators. Cancer Res (1982) 1.16
Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam Appl Toxicol (1991) 1.15
Induction of hepatic peroxisome proliferation in nonrodent species, including primates. Am J Pathol (1984) 1.14
Di-(2-ethylhexyl)phthalate: an industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rat and mice. Life Sci (1976) 1.14
Increase in hepatic carnitine acetyltransferase activity associated with peroxisomal (microbody) proliferation induced by the hypolipidemic drugs clofibrate, nafenopin, and methyl clofenapate. Res Commun Chem Pathol Pharmacol (1974) 1.14
Studies on the hepatic effects of orally administered di-)2-ethylhexyl) phthalate in the rat. Toxicol Appl Pharmacol (1975) 1.13
The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. Am J Pathol (1978) 1.13
Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion. Cell Differ (1986) 1.13
Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics. Mutat Res (1998) 1.12
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver. Cancer Res (1989) 1.11
Induction and origin of hepatocytes in rat pancreas. J Cell Biol (1984) 1.10
Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver. Cancer Res (1979) 1.09
Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J Biol Chem (1996) 1.09
Studies of pancreatic carcinogenesis in different animal models. Environ Health Perspect (1984) 1.09
Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. Gene Expr (2001) 1.08
Serum gamma glutamyl transferase as a specific indicator of bile duct lesions in the rat liver. Am J Pathol (1984) 1.08
Susceptibility of an ibred strain of guinea pigs to the induction of pancreatic adenocarcinoma by N-methyl-N-nitrosourea. J Natl Cancer Inst (1974) 1.08
Chemical urolithiasis. 1. Characteristics of bladder stone induction by terephthalic acid and dimethyl terephthalate in weanling Fischer-344 rats. Toxicol Appl Pharmacol (1981) 1.08
Transplantable pancreatic carcinoma of the rat. Science (1977) 1.07
Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42-348. J Cell Biol (1976) 1.07
Malignant tumors in rats given lasiocarpine. Cancer Res (1972) 1.06
Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds. Biochem Biophys Res Commun (1983) 1.06
Tissue specificity and species differences in the distribution of urate oxidase in peroxisomes. Lab Invest (1988) 1.04
Baculovirus expression of the Ah receptor and Ah receptor nuclear translocater. Evidence for additional dioxin responsive element-binding species and factors required for signaling. J Biol Chem (1994) 1.04
Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol (1983) 1.03
Properties of hypolipidemic peroxisome proliferators in the lymphocyte [3H]thymidine and Salmonella mutagenesis assays. Cancer Res (1980) 1.03
Response of chemically induced hepatocytelike cells in hamster pancreas to methyl clofenapate, a peroxisome proliferator. J Cell Biol (1982) 1.02
The peroxisome proliferation-associated polypeptide in rat liver. Biochem Biophys Res Commun (1977) 1.02
Excessive lipofuscin accumulation in the thyroid gland in mucoviscidosis. Arch Pathol (1973) 1.02
The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations from various species. Toxicol Appl Pharmacol (1977) 1.01
Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutations. Gene (1991) 1.01
Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypolipidemic analog of CPIB. Am J Pathol (1974) 1.01
Ultrastructural characterization of the nasal respiratory epithelium in the rat. Am J Anat (1984) 1.01
Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats. Br J Cancer (1979) 1.00
Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. Food Chem Toxicol (1987) 1.00
An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ Health Perspect (1991) 1.00
Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. Proc Natl Acad Sci U S A (1994) 0.99
alpha-Naphthylisothiocyanate induced alterations in hepatic drug metabolizing enzymes and liver morphology: implications concerning anticarcinogenesis. Carcinogenesis (1981) 0.99
Comparative studies on di-(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster. Toxicol Appl Pharmacol (1984) 0.98
Visualization of INT2 and HST1 amplification in oral squamous cell carcinomas. Genes Chromosomes Cancer (1995) 0.98
Possible properties of microbodies (peroxisomes). Microbody proliferation and hypolipidemic drugs. J Histochem Cytochem (1973) 0.98
Development of hepatocellular carcinomas and increased peroxisomal fatty acid beta-oxidation in rats fed [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643) in the semipurified diet. Carcinogenesis (1981) 0.98
Phthalate esters as peroxisome proliferator carcinogens. Environ Health Perspect (1982) 0.98
Reversible alteration of hepatic messenger RNA species for peroxisomal and non-peroxisomal proteins induced by the hypolipidaemic drug Wy-14,643. Biochem J (1983) 0.98
Differentiation of pancreatic acinar carcinoma cells cultured on rat testicular seminiferous tubular basement membranes. Cancer Res (1984) 0.98
Transdifferentiation of ductular cells into hepatocytes in regenerating hamster pancreas. Lab Invest (1990) 0.98
Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regul Toxicol Pharmacol (1998) 0.98
Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver. J Biol Chem (2001) 0.98
Studies on the effects of orally administered Di-(2-ethylhexyl) phthalate in the ferret. Toxicology (1977) 0.97