Published in Gene on April 01, 1991
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40
Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev (2010) 2.70
Characterization of the five replication factor C genes of Saccharomyces cerevisiae. Mol Cell Biol (1995) 2.69
DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. EMBO J (1992) 2.51
Characterization of DNA polymerase from Pyrococcus sp. strain KOD1 and its application to PCR. Appl Environ Microbiol (1997) 1.86
Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother (2005) 1.83
Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol (1992) 1.81
Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure. Proc Natl Acad Sci U S A (1996) 1.72
Proofreading dynamics of a processive DNA polymerase. EMBO J (2009) 1.58
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J Virol (1997) 1.46
A DNA polymerase from the archaeon Sulfolobus solfataricus shows sequence similarity to family B DNA polymerases. Nucleic Acids Res (1992) 1.46
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis. EMBO J (1996) 1.44
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J Virol (1992) 1.44
Cloning of thermostable DNA polymerases from hyperthermophilic marine Archaea with emphasis on Thermococcus sp. 9 degrees N-7 and mutations affecting 3'-5' exonuclease activity. Proc Natl Acad Sci U S A (1996) 1.42
DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1994) 1.39
The DNA polymerase gene from the hyperthermophilic marine archaebacterium, Pyrococcus furiosus, shows sequence homology with alpha-like DNA polymerases. Nucleic Acids Res (1991) 1.34
Characterization of a DNA polymerase from the uncultivated psychrophilic archaeon Cenarchaeum symbiosum. J Bacteriol (1997) 1.33
Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities. EMBO J (1992) 1.30
Antimutator mutations in the alpha subunit of Escherichia coli DNA polymerase III: identification of the responsible mutations and alignment with other DNA polymerases. Genetics (1993) 1.21
Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid. J Virol (1993) 1.21
Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids. J Virol (2003) 1.08
In vitro replication of bacteriophage PRD1 DNA. Metal activation of protein-primed initiation and DNA elongation. Nucleic Acids Res (1992) 1.08
Cold-sensitive mutants of Taq DNA polymerase provide a hot start for PCR. Nucleic Acids Res (2003) 1.02
A DNA binding motif coordinating synthesis and degradation in proofreading DNA polymerases. EMBO J (1996) 1.01
The 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases. Nucleic Acids Res (1994) 0.94
Duality of polynucleotide substrates for Phi29 DNA polymerase: 3'-->5' RNase activity of the enzyme. RNA (2008) 0.94
A positively charged residue of phi29 DNA polymerase, highly conserved in DNA polymerases from families A and B, is involved in binding the incoming nucleotide. Nucleic Acids Res (2002) 0.94
Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin. Proc Natl Acad Sci U S A (1992) 0.89
Localization of the active site of the alpha subunit of the Escherichia coli DNA polymerase III holoenzyme. J Bacteriol (1997) 0.87
Two Neurospora mitochondrial plasmids encode DNA polymerases containing motifs characteristic of family B DNA polymerases but lack the sequence Asp-Thr-Asp. Proc Natl Acad Sci U S A (1993) 0.87
Molecular evolution of a mitochondrial polB gene, encoding a family B DNA polymerase, towards the elimination from Agrocybe mitochondrial genomes. Mol Genet Genomics (2004) 0.86
A highly conserved Tyrosine residue of family B DNA polymerases contributes to dictate translesion synthesis past 8-oxo-7,8-dihydro-2'-deoxyguanosine. Nucleic Acids Res (2007) 0.86
Family A and family B DNA polymerases are structurally related: evolutionary implications. Nucleic Acids Res (1994) 0.85
Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs. Viruses (2013) 0.85
Cloning and characterization of a family B DNA polymerase from the hyperthermophilic crenarchaeon Pyrobaculum islandicum. J Bacteriol (2000) 0.84
Biochemical evidence of a physical interaction between Sulfolobus solfataricus B-family and Y-family DNA polymerases. Extremophiles (2006) 0.82
Autographa californica multiple nucleopolyhedrovirus DNA polymerase C terminus is required for nuclear localization and viral DNA replication. J Virol (2014) 0.80
The DNA polymerase from the archaebacterium Pyrococcus furiosus does not testify for a specific relationship between archaebacteria and eukaryotes. Nucleic Acids Res (1992) 0.78
Dynamics of translocation and substrate binding in individual complexes formed with active site mutants of {phi}29 DNA polymerase. J Biol Chem (2014) 0.78
Streptococcus pneumoniae DNA polymerase I lacks 3'-to-5' exonuclease activity: localization of the 5'-to-3' exonucleolytic domain. J Bacteriol (1992) 0.78
Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II. Protein Sci (1993) 0.78
Structural and functional studies on phi 29 DNA polymerase. Chromosoma (1992) 0.77
Function of the C-terminus of phi29 DNA polymerase in DNA and terminal protein binding. Nucleic Acids Res (2004) 0.77
Characterization of DNA polymerase from the hyperthermophilic archaeon Thermococcus marinus and its application to PCR. Extremophiles (2009) 0.76
Evidence that the nuclease activities associated with the herpes simplex type 1 DNA polymerase are due to the 3'-5' exonuclease. J Virol (1996) 0.76
Oligoribonucleotide (ORN) interference-PCR (ORNi-PCR): a simple method for suppressing PCR amplification of specific DNA sequences using ORNs. PLoS One (2014) 0.75
Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23
Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication. J Biol Chem (1989) 7.18
Secondary structure of vertebrate telomerase RNA. Cell (2000) 6.37
Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization. J Biol Chem (1993) 5.42
A conserved 3'----5' exonuclease active site in prokaryotic and eukaryotic DNA polymerases. Cell (1989) 4.15
Structural and functional relationships between prokaryotic and eukaryotic DNA polymerases. EMBO J (1987) 3.69
Translation of the genetic message: factors involved in the initiation of protein synthesis. Proc Natl Acad Sci U S A (1966) 3.54
Putting the stress on senescence. Curr Opin Cell Biol (2001) 3.41
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J (1999) 3.29
Characterization of a protein covalently linked to the 5' termini of the DNA of Bacillus subtilis phage phi29. J Mol Biol (1978) 3.25
Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review. Cancer (2001) 3.21
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep (2000) 3.00
Initiation of phage phi 29 DNA replication in vitro: formation of a covalent complex between the terminal protein, p3, and 5'-dAMP. Proc Natl Acad Sci U S A (1982) 2.93
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J (2001) 2.83
Persistence with treatment for hypertension in actual practice. CMAJ (1999) 2.74
Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol (1999) 2.70
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet (2000) 2.68
Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Rep (2001) 2.59
Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc Natl Acad Sci U S A (2001) 2.55
RNA polymerase binding sites and transcription map of the DNA of Bacillus subtilis phage phi29. J Mol Biol (1979) 2.48
Effect of initial drug choice on persistence with antihypertensive therapy: the importance of actual practice data. CMAJ (1999) 2.44
Direction of reading of the genetic message. J Biol Chem (1965) 2.43
DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J (2000) 2.43
Protein p3 is linked to the DNA of phage phi 29 through a phosphoester bond between serine and 5'-dAMP. Proc Natl Acad Sci U S A (1980) 2.42
Genetic analysis of bacteriophage phi 29 of Bacillus subtilis: integration and mapping of reference mutants of two collections. J Virol (1976) 2.38
The protein covalently linked to the 5' termini of the DNA of Bacillus subtilis phage phi 29 is involved in the initiation of DNA replication. Virology (1980) 2.29
Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc Natl Acad Sci U S A (1998) 2.27
Structural proteins of bacteriophage phi 29. Virology (1971) 2.19
Bacillus subtilis phage phi29. Characterization of gene products and functions. Eur J Biochem (1976) 2.17
DNA-protein complex in circular DNA from phage phi-29. Nat New Biol (1971) 2.11
Nucleotide sequence at the termini of the DNA of Bacillus subtilis phage phi 29. Proc Natl Acad Sci U S A (1981) 2.08
Phi29 family of phages. Microbiol Mol Biol Rev (2001) 2.01
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94
Physical map of bacteriophage phi29 DNA. Virology (1976) 1.91
Structure of replicating DNA molecules of Bacillus subtilis bacteriophage phi 29. J Virol (1980) 1.91
Characterization and purification of a phage phi 29-encoded DNA polymerase required for the initiation of replication. Proc Natl Acad Sci U S A (1984) 1.81
Phalloidin-induced hyperplasia of actin filaments in rat hepatocytes. Lab Invest (1975) 1.78
The bacteriophage phi 29 DNA polymerase, a proofreading enzyme. J Biol Chem (1992) 1.76
DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. J Mol Biol (2000) 1.73
Relating structure to function in phi29 DNA polymerase. J Biol Chem (1996) 1.69
Location of the serine residue involved in the linkage between the terminal protein and the DNA of phage phi 29. Nucleic Acids Res (1985) 1.68
Proteins induced in Bacillus subtilis infected with bacteriophage phi 29. Virology (1973) 1.67
Isolation of a strong suppressor of nonsense mutations in Bacillus subtilis. Eur J Biochem (1976) 1.65
A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type phi29 DNA polymerase. J Mol Biol (1999) 1.65
miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. Cell Death Differ (2010) 1.64
Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J (2003) 1.64
Replication of phage phi 29 DNA with purified terminal protein and DNA polymerase: synthesis of full-length phi 29 DNA. Proc Natl Acad Sci U S A (1985) 1.62
Helix-destabilizing activity of phi 29 single-stranded DNA binding protein: effect on the elongation rate during strand displacement DNA replication. J Mol Biol (1995) 1.61
Two interconvertible forms of yeast phosphofructokinase with different sensitivity to endproduct inhibition. Biochem Biophys Res Commun (1964) 1.60
Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication. Proc Natl Acad Sci U S A (1992) 1.57
Overproduction and purification of protein P6 of Bacillus subtilis phage phi 29: role in the initiation of DNA replication. Nucleic Acids Res (1985) 1.56
Multimeric complexes formed by DNA-binding proteins of low sequence specificity. Trends Biochem Sci (1993) 1.56
Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. J Biol Chem (2000) 1.55
Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res (2001) 1.54
Temperature-sensitive mutants affected in DNA synthesis in phage phi29 of Bacillus subtilis. Eur J Biochem (1972) 1.53
Purification in a functional form of the terminal protein of Bacillus subtilis phage phi 29. Proc Natl Acad Sci U S A (1984) 1.53
Assembly of Bacillus subtilis phage phe29. 2. Mutants in the cistrons coding for the non-structural proteins. Eur J Biochem (1977) 1.50
Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. EMBO J (1999) 1.49
The highly conserved amino acid sequence motif Tyr-Gly-Asp-Thr-Asp-Ser in alpha-like DNA polymerases is required by phage phi 29 DNA polymerase for protein-primed initiation and polymerization. Proc Natl Acad Sci U S A (1990) 1.49
Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med (2000) 1.49
Purification of bacteriophage phi 29 DNA polymerase. Methods Enzymol (1995) 1.47
Increased carotid artery intima-media thickness may be associated with stroke in primary antiphospholipid syndrome. Ann Rheum Dis (2003) 1.46
Replication of phage phi 29 DNA in vitro: role of the viral protein p6 in initiation and elongation. Nucleic Acids Res (1986) 1.44
Direction of reading of the genetic message. II. Proc Natl Acad Sci U S A (1966) 1.44
Purification and properties of DNA-dependent RNA polymerase from Bacillus subtilis vegetative cells. Eur J Biochem (1971) 1.41
Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance. Clin Exp Allergy (2013) 1.41
Nucleotide sequence of the early genes 3 and 4 of bacteriophage phi 29. Nucleic Acids Res (1982) 1.40
Evidence favouring the hypothesis of a conserved 3'-5' exonuclease active site in DNA-dependent DNA polymerases. Gene (1992) 1.39
Impaired germinal center reaction in mice with short telomeres. EMBO J (2000) 1.39
Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells. Exp Cell Res (2010) 1.35
A new mechanism for the initiation of replication of phi 29 and adenovirus DNA: priming by the terminal protein. Curr Top Microbiol Immunol (1984) 1.33
Epigenetic regulation of telomeres in human cancer. Oncogene (2008) 1.33
A novel nucleoprotein complex at a replication origin. Science (1990) 1.32
Structure of protein-containing replicative intermediates of Bacillus subtilis phage phi 29 DNA. Virology (1982) 1.32
Translation of the genetic message, iii. Formylmethionine as initiator of proteins programed by polycistronic messenger RNA. Proc Natl Acad Sci U S A (1967) 1.30
A suppressor of nonsense mutations in Bacillus subtilis. Eur J Biochem (1974) 1.30
Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities. EMBO J (1992) 1.30
Bend induced by the phage phi 29 transcriptional activator in the viral late promoter is required for activation. J Mol Biol (1990) 1.28
Translation of the genetic message. V. Effect of Mg++ and formylation of methionine in protein synthesis. Proc Natl Acad Sci U S A (1967) 1.27
Effect of NH4+ ions on phi 29 DNA-protein p3 replication: formation of a complex between the terminal protein and the DNA polymerase. J Virol (1987) 1.26
Formation of a covalent complex between the terminal protein of pneumococcal bacteriophage Cp-1 and 5'-dAMP. J Virol (1986) 1.26
Transcription activation or repression by phage psi 29 protein p4 depends on the strength of the RNA polymerase-promoter interactions. Mol Cell (1997) 1.25
Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes. Cancer Gene Ther (2007) 1.25
Overproduction and purification of the connector protein of Bacillus subtilis phage phi 29. Nucleic Acids Res (1984) 1.25
Temperature-sensitive mutants of bacteriophage phi-29. Virology (1971) 1.25
Assembly of Bacillus subtilis phage phi29. 1. Mutants in the cistrons coding for the structural proteins. Eur J Biochem (1977) 1.24
Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2011) 1.23
DNA polymerase mu, a candidate hypermutase? Philos Trans R Soc Lond B Biol Sci (2001) 1.23
Characterization of a 3'----5' exonuclease activity in the phage phi 29-encoded DNA polymerase. Nucleic Acids Res (1985) 1.23
A precursor of the neck appendage protein of B. subtilis phage phi 29. FEBS Lett (1974) 1.23
Interaction of the bacteriophage phi 29 protein p6 with double-stranded DNA. Proc Natl Acad Sci U S A (1988) 1.21