Published in J Clin Invest on July 01, 1991
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest (1996) 1.57
Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr (2012) 1.44
Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest (1996) 1.33
A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in partially pancreatectomized dogs. J Nutr (2011) 0.97
Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Diabetes (2012) 0.86
Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1. J Biol Chem (2015) 0.81
Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Diabetes (2012) 0.80
Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal. Am J Physiol Endocrinol Metab (2009) 0.78
Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production. Mol Metab (2016) 0.76
A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. Diabetes (2012) 0.75
Hyperlactatemia in patients with non-acetaminophen-related acute liver failure. World J Gastroenterol (2006) 0.75
Glucose Autoregulation is the Dominant Component of the Hormone-Independent Counterregulatory Response to Hypoglycemia in the Conscious Dog. Am J Physiol Endocrinol Metab (2017) 0.75
Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci (1969) 3.42
Hepatic vascular bed. Physiol Rev (1971) 3.11
Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem (1978) 2.93
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes (1983) 2.45
Estimation of hepatic blood flow with indocyanine green. J Clin Invest (1962) 2.30
Studies on carbohydrate metabolism in rat liver slices. X. Factors in the regulation of pathways of glucose metabolism. J Biol Chem (1958) 2.18
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci U S A (1978) 2.08
Intrinsic regulation of glucose output by rat liver. Am J Physiol (1969) 1.58
A rapid method for the determination of para-aminohippuric acid in kidney function tests. J Lab Clin Med (1951) 1.52
Effect of intraduodenal glucose administration on hepatic extraction of insulin in the anesthetized dog. J Clin Invest (1973) 1.44
Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J Clin Endocrinol Metab (1978) 1.41
Evidence for suppression of hepatic glucose-6-phosphatase with carbohydrate feeding. Diabetes (1984) 1.37
Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endocrinol Metab (1979) 1.28
Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. J Clin Invest (1978) 1.26
Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest (1991) 1.22
Glycogen synthetase activity in liver: regulation by the autonomic nerves. Science (1967) 1.22
Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver. Proc Natl Acad Sci U S A (1970) 1.22
Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J Clin Endocrinol Metab (1983) 1.21
Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes (1982) 1.20
Gluconeogenesis from alanine in normal postabsorptive man. Intrahepatic stimulatory effect of glucagon. Diabetes (1975) 1.20
Effects of glucose feeding, cortisol, and insulin on liver glycogen synthesis in the rat. Endocrinology (1967) 1.19
Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs. J Clin Invest (1983) 1.19
Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Circ Res (1975) 1.19
Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin. J Clin Invest (1982) 1.17
The stimulation of glycogen synthesis and of glycogen synthetase in the liver by the administration of glucose. Eur J Biochem (1967) 1.15
Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver. Am J Physiol (1974) 1.15
Factors modifying carbohydrate metabolism and effect of insulin in perfused rat liver. Am J Physiol (1971) 1.14
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest (1980) 1.14
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest (1987) 1.13
Glucose 6-phosphate plays a central role in the activation of glycogen synthase by glucose in hepatocytes. Biochem Biophys Res Commun (1986) 1.05
Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism. Acta Endocrinol (Copenh) (1983) 1.04
Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes (1990) 1.03
Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man. J Clin Invest (1982) 1.03
Glucose and fructose absorption in the unanesthetized dog. Gastroenterology (1963) 1.02
Studies on the effects of insulin and acetylcholine on activation of glycogen synthase and on glycogenesis in hepatocytes. Biochem Biophys Res Commun (1974) 1.01
Insulin regulation of hepatic glycogen synthase and phosphorylase. Biochemistry (1978) 1.01
Regulation of glycogen metabolism in liver by the autonomic nervous system. IV. Neural control of glycogen biosynthesis. Biochim Biophys Acta (1971) 0.96
Regulation of glycogen metabolism in liver by the autonomic nervous system. V. Activation of glycogen synthetase by vagal stimulation. Biochim Biophys Acta (1971) 0.96
The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man. Metabolism (1980) 0.96
Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism (1985) 0.95
Effect of acetylcholine on glycogen formation and the activity of glycogen synthetase in isolated, perfused rat liver. Nature (1971) 0.94
Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. J Clin Invest (1985) 0.92
Hepatic parasympathetic neural effect on glucose balance in the intact liver. Can J Physiol Pharmacol (1978) 0.90
Transient hepatic response to glucagon in man: role of insulin and hyperglycemia. Am J Physiol (1982) 0.87
The glucoregulatory response to intravenous glucose infusion in normal man: roles of insulin and glucose. Metabolism (1981) 0.87
Blood glucose levels modulate efferent activity in the vagal supply to the rat liver. J Physiol (1985) 0.83
Autoregulation by glucose of hepatic glucose balance: permissive effect of insulin. Metabolism (1981) 0.79
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes (1997) 1.64
The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest (1976) 1.59
A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes (1996) 1.53
Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest (1978) 1.52
Gluconeogenesis: methodological approaches in vivo. Fed Proc (1977) 1.47
Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism (1978) 1.44
Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition. Int J Exp Diabetes Res (2001) 1.44
Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem (1997) 1.43
Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes (1989) 1.42
Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest (1996) 1.33
Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab (2011) 1.32
Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endocrinol Metab (1979) 1.28
Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes (1993) 1.28
Absorption and disposition of a glucose load in the conscious dog. Am J Physiol (1982) 1.27
Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. J Clin Invest (1978) 1.26
Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest (1991) 1.22
Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes (1998) 1.19
Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest (1977) 1.19
Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes (2001) 1.19
Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes (1998) 1.18
Hypoglycemia in IDDM. Diabetes (1989) 1.15
Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest (1991) 1.15
Role of insulin in the regulation of leucine kinetics in the conscious dog. J Clin Invest (1982) 1.15
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J Clin Invest (1980) 1.14
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest (1987) 1.13
Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Diabetes (1973) 1.12
The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Diabetes (1977) 1.10
Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Diabetes (1981) 1.09
The effect of somatostatin on glucose uptake and production by rat tissues in vitro. Diabetes (1977) 1.08
Hepatic fuel metabolism during muscular work: role and regulation. Am J Physiol (1991) 1.07
Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab (2000) 1.06
Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Metabolism (1974) 1.06
Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol (1993) 1.06
Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol (1989) 1.06
Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem Soc Symp (1978) 1.05
Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism (1995) 1.05
Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes (2001) 1.04
Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes (1990) 1.03
Two crack cocaine body stuffers. Ann Emerg Med (1992) 1.02
Insulin as a mediator of hepatic glucose uptake in the conscious dog. Am J Physiol (1982) 1.02
Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes. Diabetes Care (2001) 1.01
A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am J Physiol (1998) 1.01
Autoregulation of hepatic glucose production. Eur J Endocrinol (1998) 1.00
Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Am J Physiol Endocrinol Metab (2004) 1.00
Regulation of net hepatic glucose uptake in vivo. Annu Rev Physiol (1992) 0.99
Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest (1995) 0.99
Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Diabetes (1974) 0.99
Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. Am J Physiol (1979) 0.98
Disposition of a mixed meal by the conscious dog. Am J Physiol (1994) 0.97
Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am J Physiol (1989) 0.96
Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Metabolism (1980) 0.96
Mechanisms of hormonal regulation of liver metabolism. Adv Cyclic Nucleotide Res (1981) 0.95
Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am J Physiol (1990) 0.95
Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs. Am J Physiol (1978) 0.95
Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs. Am J Physiol (1995) 0.94
Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. Am J Physiol (1999) 0.94
Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am J Physiol (1988) 0.94
Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Diabetes (1987) 0.94
Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Am J Physiol (1984) 0.94
A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am J Physiol (1999) 0.94
Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest (1997) 0.93
Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev (1987) 0.93
Pulsatility does not alter the response to a physiological increment in glucagon in the conscious dog. Am J Physiol (1994) 0.93
Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metabolism (1991) 0.93
Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs. Am J Physiol (1984) 0.92
Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Diabetologia (1987) 0.92
Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol (1992) 0.91
Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am J Physiol (1997) 0.91
Effects of morphine on glucose homeostasis in the conscious dog. J Clin Invest (1984) 0.90
Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Am J Physiol (1991) 0.90
Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes (1988) 0.90
Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am J Physiol (1993) 0.89
The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes (1977) 0.89
Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes (1989) 0.89
Effects of fasting on gluconeogenesis from alanine in nondiabetic man. Diabetes (1979) 0.89
Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog. Metabolism (1987) 0.88
Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Metabolism (1988) 0.88
Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs. Am J Physiol (1998) 0.88