Published in Am J Physiol on July 01, 1974
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest (1981) 5.82
Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest (1978) 1.52
Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. J Clin Invest (1978) 1.26
Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs. J Clin Invest (1983) 1.19
Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man. J Clin Invest (1982) 1.03
Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest (1991) 0.95
Role of hepatic autoregulation in defense against hypoglycemia in humans. J Clin Invest (1985) 0.86
Influence of the insulin sensitive central nervous system glucoregulator receptor on hepatic glucose metabolism. J Physiol (1975) 0.82
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 10.71
Quantitative estimation of insulin sensitivity. Am J Physiol (1979) 7.37
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (1992) 6.28
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest (1981) 5.82
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes (1993) 5.70
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet (1997) 4.39
Assessment of insulin sensitivity in vivo. Endocr Rev (1985) 4.21
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed (1986) 3.54
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology (2004) 3.54
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes (1987) 2.95
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest (1987) 2.81
Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (1998) 2.57
Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA (1998) 2.56
Micropuncture studies of the electrochemical aspects of fluid and electrolyte transport in individual seminiferous tubules, the epididymis and the vas deferens in rats. J Physiol (1971) 2.44
Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest (1989) 2.32
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet (1999) 2.08
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res (1997) 2.06
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol (2000) 2.05
Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes (1993) 2.03
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A (2000) 2.02
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A (1999) 1.91
Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes (1995) 1.91
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr. Am J Physiol Endocrinol Metab (2001) 1.86
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Hum Mol Genet (2000) 1.84
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res (2000) 1.83
Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered (1999) 1.76
A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study. Diabetes (1994) 1.73
Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab (1990) 1.71
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours. J Med Genet (2003) 1.69
Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care (1996) 1.68
Quantitative estimation of beta cell sensitivity to glucose in the intact organism: a minimal model of insulin kinetics in the dog. Diabetes (1980) 1.67
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest (1993) 1.67
Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients. Diabetes Care (1994) 1.67
Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. J Clin Endocrinol Metab (1998) 1.63
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes (2000) 1.63
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest (1996) 1.60
Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS) Am J Clin Nutr (1997) 1.59
Diurnal variation in glucose tolerance. Cyclic suppression of insulin action and insulin secretion in normal-weight, but not obese, subjects. Diabetes (1992) 1.56
Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol (1987) 1.54
Solute and water flows in thin limbs of Henle's loop in the hamster kidney. Am J Physiol (1970) 1.54
Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes (2000) 1.52
Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene. Hum Mol Genet (1994) 1.51
Germline mutation of the tumour suppressor PTEN in Proteus syndrome. J Med Genet (2002) 1.50
Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol (1990) 1.48
Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab (1997) 1.48
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest (1996) 1.45
Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab (1985) 1.43
Ethnic differences in carotid wall thickness. The Insulin Resistance Atherosclerosis Study. Stroke (1996) 1.42
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes (1997) 1.42
Genetic testing for familial cancer. Consequences of RET proto-oncogene mutation analysis in multiple endocrine neoplasia, type 2. Arch Surg (1997) 1.41
Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes (1997) 1.36
The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab (1990) 1.35
Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p. Cancer Res (2000) 1.35
Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation. J Clin Endocrinol Metab (1997) 1.31
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol (1990) 1.31
Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol (1999) 1.30
The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes (1986) 1.30
Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol (1990) 1.29
Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes (1988) 1.28
Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system. Ann N Y Acad Sci (1969) 1.28
Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. J Clin Endocrinol Metab (2000) 1.25
Influence of total vs. visceral fat on insulin action and secretion in African American and white children. Obes Res (2001) 1.25
Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol Endocrinol Metab (2000) 1.24
Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. Am J Med Genet (1998) 1.24
Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people. J Gerontol A Biol Sci Med Sci (2001) 1.23
Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest (1997) 1.22
Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. J Clin Invest (1996) 1.21
Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes (1982) 1.20
Three-dimensional anatomy and renal concentrating mechanism. I. Modeling results. Am J Physiol (1991) 1.19
Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc (1980) 1.18
Genotype-phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium. J Intern Med (1995) 1.17
Potentiation by vasopressin of corticotropin release induced by corticotropin-releasing factor. Endocrinology (1971) 1.17
Male breast cancer in Cowden syndrome patients with germline PTEN mutations. J Med Genet (2001) 1.17
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences. Diabetes (2001) 1.17
A dynamic model of the tubuloglomerular feedback mechanism. Am J Physiol (1990) 1.16
Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci U S A (1994) 1.15
Renal blood flow regulation and arterial pressure fluctuations: a case study in nonlinear dynamics. Physiol Rev (1994) 1.15
Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension (1991) 1.15
Diminished insulin sensitivity and increased insulin response in nonobese, nondiabetic Mexican Americans. Metabolism (1990) 1.14
Mechanism of NaCl reabsorption by hamster thin ascending limbs of Henle's loop. Am J Physiol (1975) 1.14
Mutational analysis and genotype-phenotype correlation of the PHEX gene in X-linked hypophosphatemic rickets. J Clin Endocrinol Metab (2001) 1.14
A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. Oncogene (1998) 1.13
Integrated control of hepatic glucose metabolism. Fed Proc (1977) 1.12
Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes (1991) 1.12
Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport. J Clin Invest (1991) 1.12
The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects. Diabetes (1994) 1.12
Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys. Diabetes (1994) 1.12
Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol (1996) 1.11
Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer. Oncogene (1998) 1.10
Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes (2000) 1.09
Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes (1985) 1.09
Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes (1989) 1.09
Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol (1983) 1.09
Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am J Physiol (1998) 1.08
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia (2009) 1.08