Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMC 2943146)

Published in Sci Transl Med on June 23, 2010

Authors

Matthew D Taylor1, Sanjoy Sadhukhan, Ponnappa Kottangada, Archana Ramgopal, Koustav Sarkar, Sheryl D'Silva, Annamalai Selvakumar, Fabio Candotti, Yatin M Vyas

Author Affiliations

1: Division of Pediatric Hematology-Oncology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Articles citing this

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood (2011) 1.85

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev (2011) 1.67

T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity (2014) 1.28

Autoimmunity in wiskott-Aldrich syndrome: an unsolved enigma. Front Immunol (2012) 1.27

Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development. Science (2013) 1.13

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest (2013) 1.04

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination. Development (2011) 1.02

Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression. Small GTPases (2014) 0.98

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling. Haematologica (2011) 0.91

Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90

Genetics of allergy and allergic sensitization: common variants, rare mutations. Curr Opin Immunol (2015) 0.89

Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization. J Immunol (2014) 0.88

Actin nucleators in the nucleus: an emerging theme. J Cell Sci (2012) 0.87

Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins. Cell Mol Life Sci (2012) 0.87

Nuclear actin and transcriptional activation. Commun Integr Biol (2011) 0.86

B-cell reconstitution after lentiviral vector-mediated gene therapy in patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol (2015) 0.86

Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells. J Cell Sci (2014) 0.81

Nuclear F-actin enhances the transcriptional activity of β-catenin by increasing its nuclear localization and binding to chromatin. Histochem Cell Biol (2016) 0.80

SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells. Blood (2015) 0.79

Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities. Nucleus (2015) 0.78

Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome. Blood (2014) 0.78

Nuclear actin in transcriptional reprogramming by oocytes: are actin nucleators key players? Cell Cycle (2011) 0.78

Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott-Aldrich Syndrome. Front Immunol (2015) 0.77

Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection. Am J Transplant (2015) 0.75

Insights into primary immune deficiency from quantitative microscopy. J Allergy Clin Immunol (2015) 0.75

Human Immunodeficiencies Related to Defective APC/T Cell Interaction. Front Immunol (2015) 0.75

Nuclear Actin in Development and Transcriptional Reprogramming. Front Genet (2017) 0.75

Cellular functions of WASP family proteins at a glance. J Cell Sci (2017) 0.75

Articles cited by this

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41

A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61

The complex language of chromatin regulation during transcription. Nature (2007) 16.97

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73

Heterochromatin revisited. Nat Rev Genet (2007) 8.70

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell (2009) 8.69

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol (2002) 7.28

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30

H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet (2009) 5.82

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78

Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell (1996) 5.67

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49

Protein dynamics: implications for nuclear architecture and gene expression. Science (2001) 4.38

Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37

Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding. Genome Res (2008) 4.11

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell (1994) 4.04

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell (2008) 3.53

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32

CEAS: cis-regulatory element annotation system. Nucleic Acids Res (2006) 3.15

A rapid micro chromatin immunoprecipitation assay (microChIP). Nat Protoc (2008) 3.14

Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCR. J Mol Biol (2001) 2.97

Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84

Nuclear actin and actin-related proteins in chromatin remodeling. Annu Rev Biochem (2001) 2.74

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72

Crosstalk among Histone Modifications. Cell (2008) 2.70

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet (2006) 2.62

Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol (2006) 2.52

Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Mol Cell (2009) 2.32

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat Struct Mol Biol (2007) 2.22

Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol (2007) 2.13

Clinical course of patients with WASP gene mutations. Blood (2003) 2.06

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo. Curr Biol (2002) 1.90

The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med (2007) 1.81

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood (2006) 1.80

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev (2008) 1.79

Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin. Mol Cell Biol (2007) 1.78

A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature (2004) 1.77

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest (2007) 1.77

Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70

Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression. FEBS J (2009) 1.49

Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly. Mol Cell (2005) 1.45

Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients. J Immunol (2006) 1.44

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A (2004) 1.34

A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. J Biol Chem (2007) 1.28

Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology (2007) 1.21

Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A (2009) 1.18

Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. J Biol Chem (2003) 1.10

At the crossroads of T helper lineage commitment-Epigenetics points the way. Biochim Biophys Acta (2008) 1.05

The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J Immunol (2005) 1.04

Transcriptional control of gene expression by actin and myosin. Int Rev Cell Mol Biol (2009) 0.99

A role for Wiskott-Aldrich syndrome protein in T-cell receptor-mediated transcriptional activation independent of actin polymerization. J Biol Chem (2001) 0.97

Articles by these authors

(truncated to the top 100)

Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70

Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med (2014) 2.71

Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol (2002) 2.38

Engraftment potential of human amnion and chorion cells derived from term placenta. Transplantation (2004) 2.18

Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses. Proc Natl Acad Sci U S A (2003) 2.09

Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J Immunol (2003) 2.00

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1(+) leukemias. Blood (2012) 1.81

How I treat ADA deficiency. Blood (2009) 1.70

A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol (2006) 1.58

Gene therapy: X-SCID transgene leukaemogenicity. Nature (2006) 1.57

Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience. Cancer (2005) 1.55

Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans. Blood (2007) 1.52

KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in vitro. J Immunol (2007) 1.43

Cytokines and their role in lymphoid development, differentiation and homeostasis. Curr Opin Allergy Clin Immunol (2002) 1.40

Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40

Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. J Clin Invest (2017) 1.39

Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. Blood (2002) 1.39

The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res (2013) 1.35

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.33

Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients. J Immunol (2004) 1.33

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet (2008) 1.31

American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells. Mol Ther (2003) 1.29

Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs. Immunol Rev (2005) 1.28

Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy. Hum Gene Ther (2002) 1.27

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood (2012) 1.27

Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Clin Invest (2010) 1.27

Gene therapy fulfilling its promise. N Engl J Med (2009) 1.24

Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. J Allergy Clin Immunol (2009) 1.23

Autoimmunity in Wiskott-Aldrich syndrome. Curr Opin Rheumatol (2003) 1.20

Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs. PLoS One (2013) 1.19

Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood (2010) 1.14

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation (2009) 1.13

A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors. Blood (2004) 1.12

Jak3 and the pathogenesis of severe combined immunodeficiency. Mol Immunol (2004) 1.09

Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. J Allergy Clin Immunol (2011) 1.08

Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. J Clin Invest (2003) 1.08

Revertant somatic mosaicism in the Wiskott-Aldrich syndrome. Immunol Res (2009) 1.05

Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood (2005) 1.04

The Wiskott-Aldrich syndrome protein regulates nuclear translocation of NFAT2 and NF-kappa B (RelA) independently of its role in filamentous actin polymerization and actin cytoskeletal rearrangement. J Immunol (2005) 1.04

Somatic mosaicism in primary immune deficiencies. Curr Opin Allergy Clin Immunol (2008) 1.03

Neuropeptide Y in the forebrain of the adult male cichlid fish Oreochromis mossambicus: distribution, effects of castration and testosterone replacement. J Comp Neurol (2005) 1.00

Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol (2007) 0.98

Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. J Immunol (2008) 0.98

NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand. J Immunol (2013) 0.97

A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy. J Immunol (2009) 0.97

The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP). Int Immunol (2007) 0.96

Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood (2006) 0.95

CXCL12 signaling is independent of Jak2 and Jak3. J Biol Chem (2004) 0.95

Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment. Hum Immunol (2008) 0.94

Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family. Blood (2004) 0.94

Cartilage hair hypoplasia mutations that lead to RMRP promoter inefficiency or RNA transcript instability. Am J Med Genet A (2007) 0.94

Neem leaf glycoprotein induces perforin-mediated tumor cell killing by T and NK cells through differential regulation of IFNgamma signaling. J Immunother (2009) 0.92

Lessons from the Wiskott-Aldrich syndrome. N Engl J Med (2006) 0.92

Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. Mol Ther (2009) 0.91

Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome. Mol Ther (2012) 0.91

Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency. Blood (2011) 0.90

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. J Clin Invest (2015) 0.88

Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory. J Biol Chem (2007) 0.88

Measurement of proliferative responses of cultured lymphocytes. Curr Protoc Immunol (2008) 0.87

Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages. Blood (2003) 0.87

The phenomenon of spontaneous genetic reversions in the Wiskott-Aldrich syndrome: a report of the workshop of the ESID Genetics Working Party at the XIIth Meeting of the European Society for Immunodeficiencies (ESID). Budapest, Hungary October 4-7, 2006. J Clin Immunol (2007) 0.87

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients. J Biol Chem (2003) 0.87

In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals. Blood (2003) 0.87

Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions. Vaccine (2009) 0.86

Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. Int Immunopharmacol (2007) 0.86

Defective dendritic cell generation from monocytes is a potential reason for poor therapeutic efficacy of interferon α2b (IFNα2b) in cervical cancer. Transl Res (2011) 0.85

Reconstitution of lymphoid development and function in ZAP-70-deficient mice following gene transfer into bone marrow cells. Blood (2002) 0.85

Unprecedented diversity of genotypic revertants in lymphocytes of a patient with Wiskott-Aldrich syndrome. Blood (2008) 0.85

Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction. Hum Gene Ther (2002) 0.85

Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood (2011) 0.85

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest (2016) 0.84

Measurement of proliferative responses of cultured lymphocytes. Curr Protoc Immunol (2011) 0.84

Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: histological, biochemical and immunological perspectives. Int Immunopharmacol (2012) 0.83

A sociodemographic study of multidrug resistant tuberculosis cases from DOTS clinics of Kolkata. J Indian Med Assoc (2012) 0.83

Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene. Cancer Chemother Pharmacol (2002) 0.83

Platelets from WAS patients show an increased susceptibility to ex vivo phagocytosis. Platelets (2012) 0.82

Isolation of RNA from field-grown jute (Corchorus capsularis) plant in different developmental stages for effective downstream molecular analysis. Mol Biotechnol (2011) 0.81

Genetics. Mosaicism--switch or spectrum? Science (2010) 0.81

Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity. Cell Mol Immunol (2010) 0.81

Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol (2012) 0.80

Immune responses to gene-modified T cells. Curr Gene Ther (2007) 0.80

Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. J Clin Immunol (2015) 0.80

Neem leaf glycoprotein activates CD8(+) T cells to promote therapeutic anti-tumor immunity inhibiting the growth of mouse sarcoma. PLoS One (2013) 0.80

Somatic mosaicism in the Wiskott-Aldrich syndrome: molecular and functional characterization of genotypic revertants. Clin Immunol (2010) 0.80

High incidence of lymphomas in a subgroup of Wiskott-Aldrich syndrome patients. Br J Haematol (2003) 0.80

Recent advances in gene therapy for severe congenital immunodeficiency diseases. Curr Opin Hematol (2008) 0.80

Neem leaf glycoprotein inhibits CD4+CD25+Foxp3+ Tregs to restrict murine tumor growth. Immunotherapy (2011) 0.80

Dysregulated CC receptor/ligand in monocytes/macrophages from tongue squamous cell carcinoma patients is partially rectified by interferon α-2b. Hum Immunol (2011) 0.79

A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest. J Virol (2012) 0.79

Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus. J Immunol (2006) 0.79

Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase. Mol Cancer Ther (2002) 0.78

A monoclonal antibody against neem leaf glycoprotein recognizes carcinoembryonic antigen (CEA) and restricts CEA expressing tumor growth. J Immunother (2014) 0.78

Artificial antigen presenting cells that express prevalent HLA alleles: A step towards the broad application of antigen-specific adoptive cell therapies. Discov Med (2009) 0.78

Gene therapy in infants with severe combined immunodeficiency. BioDrugs (2002) 0.77

Retroviral-mediated gene transfer restores IL-12 and IL-23 signaling pathways in T cells from IL-12 receptor beta1-deficient patients. Mol Ther (2004) 0.77

Elevated IgE and atopy in patients treated for early-onset ADA-SCID. J Allergy Clin Immunol (2013) 0.77

Molecular characterization of the HLA-Cw*0409N allele. Hum Immunol (2002) 0.77

Immunotherapeutic targeting of established sarcoma in Swiss mice by tumor-derived antigen-pulsed NLGP matured dendritic cells is CD8+ T-cell dependent. Immunotherapy (2014) 0.77

Identification of differentially expressed transcripts associated with bast fibre development in Corchorus capsularis by suppression subtractive hybridization. Planta (2014) 0.76

Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases. Proc Natl Acad Sci U S A (2013) 0.76