Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes.

PubWeight™: 1.66‹?› | Rank: Top 3%

🔗 View Article (PMC 3269780)

Published in Chem Res Toxicol on July 19, 2010

Authors

Angela S Burke1, Lee Ann MacMillan-Crow, Jack A Hinson

Author Affiliations

1: Department of Pharmacology and Toxicology College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Articles citing this

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res (2010) 1.45

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther (2010) 1.38

Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury. Free Radic Biol Med (2013) 1.05

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biol (2013) 0.97

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. Food Chem Toxicol (2013) 0.96

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice. J Pharmacol Exp Ther (2011) 0.90

Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol (2015) 0.88

Changes in mouse liver protein glutathionylation after acetaminophen exposure. J Pharmacol Exp Ther (2011) 0.86

Functional roles of protein nitration in acute and chronic liver diseases. Oxid Med Cell Longev (2014) 0.85

Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting. Chem Res Toxicol (2011) 0.85

Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther (2012) 0.82

Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers. Free Radic Biol Med (2012) 0.81

Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food Chem Toxicol (2015) 0.80

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol (2015) 0.79

Novel in vitro and mathematical models for the prediction of chemical toxicity. Toxicol Res (Camb) (2012) 0.78

The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med (2015) 0.76

Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity. J Pharmacol Exp Ther (2016) 0.75

Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. Toxicol Rep (2017) 0.75

Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes: a cautionary note on the impact of cell culture conditions. Chem Res Toxicol (2010) 0.75

Articles cited by this

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol (1996) 13.14

Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med (2000) 5.90

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther (1973) 5.23

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta (1998) 4.50

Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13

Acetaminophen-induced hepatotoxicity. Drug Metab Dispos (2003) 3.22

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci U S A (1984) 3.09

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92

Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol (1995) 2.90

Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol (2010) 2.54

Evaluation of the probes 2',7'-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol (2003) 2.43

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41

Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide (1997) 2.11

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Pharmacol Exp Ther (2004) 1.97

Nitric oxide synthase activity in mitochondria. FEBS Lett (1997) 1.81

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology (2002) 1.67

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem (1998) 1.58

The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug Metab Dispos (2006) 1.54

Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide. Arch Biochem Biophys (1998) 1.54

Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem Res Toxicol (1998) 1.38

Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc Natl Acad Sci U S A (2002) 1.33

The nature of heme/iron-induced protein tyrosine nitration. Proc Natl Acad Sci U S A (2003) 1.28

Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide (2002) 1.22

Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes. Hepatology (1999) 1.18

Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS. Free Radic Biol Med (2003) 1.16

Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J Biol Chem (1998) 1.16

Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide (2001) 1.16

Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated rats. Lab Invest (1994) 1.07

Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic Biol Med (2000) 0.98

Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. Toxicol Sci (2000) 0.97

Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress. Biochem Biophys Res Commun (2006) 0.96

The inhibition of the constitutive and inducible nitric oxide synthase isoforms by indazole agents. Arch Biochem Biophys (1994) 0.94

Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. Toxicol Appl Pharmacol (1986) 0.92

Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct. Biochemistry (1999) 0.91

Mitochondrial dysfunction in paracetamol hepatotoxicity: in vitro studies in isolated mouse hepatocytes. Toxicol Lett (1990) 0.89

Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol. Food Chem Toxicol (1987) 0.88

Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes. Toxicology (1994) 0.86

Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity. Can J Physiol Pharmacol (1993) 0.86

Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline. Ann Rheum Dis (1996) 0.84

New aspects in the reaction mechanism of phenol with peroxynitrite: the role of phenoxy radicals. Nitric Oxide (1998) 0.83

On the selectivity of 7-nitroindazole as an inhibitor of neuronal nitric oxide synthase. Trends Pharmacol Sci (1998) 0.82

Nitrating reactive nitric oxygen species transform acetaminophen to 3-nitroacetaminophen. Chem Res Toxicol (2000) 0.81

Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A (2007) 0.81

Galactosamine decreases nitric oxide formation in cultured rat hepatocytes: mechanism of suppression. J Biochem Mol Toxicol (1999) 0.77

Articles by these authors

Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13

Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology (2006) 3.85

Acetaminophen-induced hepatotoxicity. Drug Metab Dispos (2003) 3.22

Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics (2006) 2.96

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos (2002) 2.34

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Pharmacol Exp Ther (2004) 1.97

Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos (2009) 1.95

Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicol Sci (2003) 1.52

Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.40

Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radic Biol Med (2007) 1.38

Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther (2010) 1.38

In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol Pharmacol (2004) 1.30

Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury. Am J Physiol Renal Physiol (2014) 1.25

NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver Physiol (2004) 1.23

Mitochondrial targets of oxidative stress during renal ischemia/reperfusion. Arch Biochem Biophys (2003) 1.21

Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Free Radic Biol Med (2009) 1.20

Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol (2005) 1.13

Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Am J Physiol Gastrointest Liver Physiol (2006) 1.12

Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free Radic Res (2003) 1.10

The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. J Pharmacol Exp Ther (2010) 1.05

Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochem Pharmacol (2010) 1.04

Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse. Biochem Biophys Res Commun (2003) 1.03

Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress. Biochem Biophys Res Commun (2006) 0.96

Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression. Basic Clin Pharmacol Toxicol (2005) 0.96

Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther (2012) 0.93

Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity. J Pharmacol Exp Ther (2010) 0.92

NAD(P)H oxidase contributes to the progression of remote hepatic parenchymal injury and endothelial dysfunction, but not microvascular perfusion deficits. Am J Physiol Gastrointest Liver Physiol (2005) 0.92

Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med (2010) 0.91

Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice. J Pharmacol Exp Ther (2011) 0.90

Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicol Appl Pharmacol (2011) 0.90

Overexpression of manganese superoxide dismutase protects against ATP depletion-mediated cell death of proximal tubule cells. Arch Biochem Biophys (2005) 0.87

Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat? Neurosci Lett (2006) 0.87

Changes in mouse liver protein glutathionylation after acetaminophen exposure. J Pharmacol Exp Ther (2011) 0.86

Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury. J Pharmacol Exp Ther (2011) 0.82

Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther (2012) 0.82

Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact (2010) 0.82

Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis? Am J Physiol Renal Physiol (2012) 0.82

Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells. PLoS One (2012) 0.81

Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo. Comp Hepatol (2004) 0.81

Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A (2007) 0.81

The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models. Antioxid Redox Signal (2013) 0.80

Effect of S-nitrosoglutathione on renal mitochondrial function: a new mechanism for reversible regulation of manganese superoxide dismutase activity? Free Radic Biol Med (2012) 0.78

Peroxynitrite modulates acidic fibroblast growth factor (FGF-1) activity. Arch Biochem Biophys (2003) 0.78

Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol (2011) 0.78

Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol (2012) 0.77

Correlation of MCP1 with toxicity in acetaminophen overdose. J Ark Med Soc (2004) 0.75