gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 2930197)

Published in Biol Psychiatry on July 01, 2010

Authors

Qiuying Shen1, Rachnanjali Lal, Beth A Luellen, John C Earnheart, Anne Milasincic Andrews, Bernhard Luscher

Author Affiliations

1: Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, 16801, USA.

Articles citing this

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov (2011) 2.65

The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci (2011) 2.36

GABAA receptor trafficking-mediated plasticity of inhibitory synapses. Neuron (2011) 2.05

The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry (2010) 1.80

Studies in genetically modified mice suggest novel mechanisms of mood regulation. Biol Psychiatry (2010) 1.38

Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia. Arch Gen Psychiatry (2011) 1.23

GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism. Annu Rev Pharmacol Toxicol (2013) 1.20

Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12

Antidepressant-like properties of α2-containing GABA(A) receptors. Behav Brain Res (2010) 1.06

Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation. PLoS One (2012) 1.04

Functional regulation of GABAA receptors in nervous system pathologies. Curr Opin Neurobiol (2011) 1.03

α2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacol Ther (2012) 1.00

Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology (2011) 0.98

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. J Neurosci (2013) 0.96

Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice. Neuropsychopharmacology (2014) 0.96

Altered GABA transmission in a mouse model of increased trait anxiety. Neuroscience (2011) 0.96

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights. Front Genet (2012) 0.95

The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species. Front Psychiatry (2013) 0.95

Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Front Neuroendocrinol (2013) 0.93

Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor. Psychopharmacology (Berl) (2013) 0.89

Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice. PLoS One (2013) 0.87

Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment. Biol Psychiatry (2016) 0.86

GABAergic control of depression-related brain states. Adv Pharmacol (2015) 0.86

GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice. PLoS One (2012) 0.84

Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations. PLoS One (2011) 0.84

Sex chromosome complement regulates expression of mood-related genes. Biol Sex Differ (2013) 0.83

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Brain Res (2012) 0.82

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response. Front Neuroendocrinol (2014) 0.82

Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice. Int J Neuropsychopharmacol (2015) 0.82

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice. Neuropharmacology (2014) 0.81

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state. Mol Psychiatry (2016) 0.81

Diabetes induces GABA receptor plasticity in murine vagal motor neurons. J Neurophysiol (2015) 0.81

Gastrodiae Rhizoma (tiān má): a review of biological activity and antidepressant mechanisms. J Tradit Complement Med (2011) 0.80

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility. Neuroscience (2016) 0.79

Repeated administration of imipramine modifies GABAergic transmission in rat frontal cortex. J Neural Transm (Vienna) (2012) 0.79

Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. PLoS One (2013) 0.79

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. Front Pharmacol (2016) 0.78

Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology (2014) 0.78

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment. Mol Psychiatry (2015) 0.77

Prefrontal Cortex GABAergic Deficits and Circuit Dysfunction in the Pathophysiology and Treatment of Chronic Stress and Depression. Curr Opin Behav Sci (2017) 0.75

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for σ1 receptors in picrotoxin-treated mice. Br J Pharmacol (2016) 0.75

EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress. Neuropsychopharmacology (2016) 0.75

Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain. Neural Plast (2017) 0.75

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors. Behav Brain Res (2017) 0.75

Articles cited by this

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14

Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA (2010) 13.88

Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci (2009) 11.02

Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry (1999) 7.84

The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) (1985) 7.53

Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry (2008) 4.98

Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry (2004) 3.64

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nat Neurosci (1999) 3.36

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol (1997) 2.67

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry (2008) 2.38

The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci (2003) 2.18

Association of depression with medical illness: does cortisol play a role? Biol Psychiatry (2004) 2.05

GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry (2008) 2.04

Evidence of cortical inhibitory deficits in major depressive disorder. Biol Psychiatry (2009) 2.01

Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev (1996) 1.90

Assessing anhedonia in psychiatric patients. Arch Gen Psychiatry (1983) 1.83

Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One (2009) 1.78

Early life influences on life-long patterns of behavior and health. Ment Retard Dev Disabil Res Rev (2003) 1.68

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Acute and continuation treatment of major depressive disorder. World J Biol Psychiatry (2002) 1.63

The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology (Berl) (1988) 1.63

Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. Behav Genet (2006) 1.63

Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. J Neurosci (2004) 1.62

Comorbidity of mood and anxiety disorders. Depress Anxiety (2000) 1.59

Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods (2004) 1.59

Major depression and generalised anxiety disorder. Same genes, (partly)different environments--revisited. Br J Psychiatry Suppl (1996) 1.58

Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients. Int J Neuropsychopharmacol (2007) 1.57

What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? Eur Arch Psychiatry Clin Neurosci (2007) 1.52

A twin study of anxiety-related behaviours in pre-school children. J Child Psychol Psychiatry (2003) 1.48

Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment. CNS Neurol Disord Drug Targets (2007) 1.47

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry (2007) 1.45

Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res (2008) 1.45

Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biol Psychiatry (2006) 1.44

Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology (2008) 1.42

Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry (2008) 1.42

GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci (2007) 1.41

Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis (2004) 1.37

Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev (1985) 1.36

Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology (Berl) (1995) 1.36

Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology (2003) 1.36

Functional role of local GABAergic influences on the HPA axis. Brain Struct Funct (2008) 1.31

Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. Am J Psychiatry (1994) 1.26

Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice. Neuropsychopharmacology (2004) 1.22

Cognitive function in depression: a distinct pattern of frontal impairment in melancholia? Psychol Med (1999) 1.20

Numerous GABAergic afferents to locus ceruleus in the pericerulear dendritic zone: possible interneuronal pool. J Neurosci (2004) 1.20

24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment. J Clin Endocrinol Metab (1987) 1.18

Corticotropin-releasing hormone in depression and post-traumatic stress disorder. Peptides (2001) 1.12

Pharmacotherapy for major depression with melancholic features: relative efficacy of tricyclic versus selective serotonin reuptake inhibitor antidepressants. J Affect Disord (1996) 1.11

Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry (1996) 1.10

An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharmacol (1987) 1.06

Diminished anxiety- and depression-related behaviors in mice with selective deletion of the Tac1 gene. J Neurosci (2002) 1.05

A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. The Venlafaxine French Inpatient Study Group. Int Clin Psychopharmacol (1994) 1.05

Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase. J Neurosci (2008) 1.01

Differential corticosteroid modulation of inhibitory synaptic currents in the dorsal and ventral hippocampus. J Neurosci (2009) 1.00

Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity. Acta Psychiatr Scand (2004) 0.99

Are the newer antidepressant drugs as effective as established physical treatments? Results from an Australasian clinical panel review. Aust N Z J Psychiatry (1999) 0.93

Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone. J Neurosci (2001) 0.92

Effects of antidepressants on the brain/plasma distribution of corticosterone. Neuropsychopharmacology (2006) 0.90

Endocrine disturbances in depression. J Endocrinol Invest (2005) 0.89

GABA receptor modulation of 5-HT neuronal firing: characterization and effect of moderate in vivo variations in glucocorticoid levels. Neurochem Int (2004) 0.89

Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding. Eur J Pharmacol (2008) 0.88

HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology (2004) 0.88

Assessing the comparative effectiveness of antidepressant therapies: a prospective clinical practice study. J Clin Psychiatry (2001) 0.87

Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacol Biochem Behav (2000) 0.85

Hormonal differences between psychotic and non-psychotic melancholic depression. J Affect Disord (2006) 0.84

Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons. Biol Psychiatry (2003) 0.84

Desipramine prevents the sustained increase in corticotropin-releasing hormone-like immunoreactivity induced by repeated immobilization stress in the rat central extended amygdala. J Neurosci Res (2006) 0.83

Response selection deficits in melancholic but not nonmelancholic unipolar major depression. J Clin Exp Neuropsychol (2004) 0.81

Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder. Neuropsychopharmacology (1997) 0.78

Melancholia with onset during treatment with SSRIs. Ann Clin Psychiatry (1998) 0.77

Articles by these authors

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73

SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A (2009) 1.39

Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci (2008) 1.05

Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. J Neurosci (2007) 1.00

γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting. J Biol Chem (2012) 0.96

Multiple molecular mechanisms for a single GABAA mutation in epilepsy. Neurology (2013) 0.95

Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures. J Physiol (2006) 0.93

The biochemical anatomy of cortical inhibitory synapses. PLoS One (2012) 0.90

Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells. ACS Chem Neurosci (2012) 0.89

GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice. PLoS One (2012) 0.84

Development of a stabilized form of the regulatory CK2beta subunit that inhibits cell proliferation. J Biol Chem (2007) 0.80

A physical model of axonal damage due to oxidative stress. Proc Natl Acad Sci U S A (2006) 0.79

Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine. J Pharmacol Exp Ther (2003) 0.76

Gamma-aminobutyric acidergic deficits cause melancholic depression: a reply to Markou and Geyer. Biol Psychiatry (2010) 0.75

Why Monitor Molecules in Neuroscience? ACS Chem Neurosci (2017) 0.75

Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse. Neuroendocrinology (2002) 0.75