PubRank

Britta Engelhardt

Author PubWeight™ 103.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005 6.86
2 C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009 5.97
3 The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 2012 3.07
4 Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J Clin Invest 2002 2.50
5 Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis 2008 2.26
6 Strategies to advance translational research into brain barriers. Lancet Neurol 2008 2.16
7 Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood 2009 2.10
8 Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol 2003 1.99
9 Alpha4 integrins as therapeutic targets in autoimmune disease. N Engl J Med 2003 1.90
10 VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med 2008 1.78
11 Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis 2006 1.75
12 Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis. J Exp Med 2003 1.58
13 Perivascular spaces and the two steps to neuroinflammation. J Neuropathol Exp Neurol 2008 1.52
14 A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem 2002 1.45
15 Mouse CD99 participates in T-cell recruitment into inflamed skin. Blood 2004 1.42
16 Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis. J Neuropathol Exp Neurol 2006 1.41
17 Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol 2004 1.39
18 Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med 2005 1.37
19 T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 2003 1.36
20 Immunologic privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab 2012 1.30
21 Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A 2009 1.27
22 Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. J Cereb Blood Flow Metab 2009 1.27
23 Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol 2002 1.27
24 Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm Res 2003 1.26
25 Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci 2011 1.25
26 Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol 2010 1.24
27 Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood 2010 1.22
28 Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Signal 2011 1.21
29 Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol 2003 1.21
30 Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J 2003 1.20
31 Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol 2011 1.16
32 T-cell trafficking in the central nervous system. Immunol Rev 2012 1.15
33 Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS One 2009 1.13
34 Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node. Eur J Immunol 2008 1.12
35 Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J Immunol 2009 1.11
36 Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro. Ann Neurol 2004 1.10
37 Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res 2003 1.09
38 Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. J Immunol 2011 1.07
39 Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology 2008 1.06
40 Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta Neuropathol 2009 1.05
41 Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice. Exp Cell Res 2008 1.03
42 The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis. Cerebrospinal Fluid Res 2005 1.03
43 E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol 2007 1.02
44 Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res 2011 1.00
45 The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol 2012 1.00
46 Polyoma virus middle-T-transformed PECAM-1 deficient mouse brain endothelial cells proliferate rapidly in culture and form hemangiomas in mice. J Cell Physiol 2005 0.99
47 Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. J Immunol 2010 0.99
48 Functions of lipid raft membrane microdomains at the blood-brain barrier. J Mol Med (Berl) 2009 0.99
49 Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS One 2013 0.98
50 Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation. J Cereb Blood Flow Metab 2010 0.96
51 Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia 2012 0.95
52 Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo. Eur J Immunol 2002 0.94
53 Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors. In Vitro Cell Dev Biol Anim 2002 0.94
54 IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. J Neuroimmunol 2008 0.93
55 β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier. J Immunol 2013 0.92
56 Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice. Brain Pathol 2005 0.91
57 Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur J Immunol 2015 0.91
58 Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha. Brain Res Mol Brain Res 2003 0.90
59 TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis. Eur J Immunol 2011 0.87
60 Going against the tide--how encephalitogenic T cells breach the blood-brain barrier. J Vasc Res 2012 0.86
61 Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proc Natl Acad Sci U S A 2013 0.85
62 Building up the blood-brain barrier. Nat Med 2003 0.84
63 Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochem Int 2008 0.84
64 Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologues. Eur J Immunol 2006 0.83
65 Endogenous estrogens, through estrogen receptor α, constrain autoimmune inflammation in female mice by limiting CD4+ T-cell homing into the CNS. Eur J Immunol 2010 0.83
66 Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids Barriers CNS 2013 0.82
67 Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J Neuroimmunol 2007 0.81
68 L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis. Eur J Immunol 2008 0.81
69 Glycosylation processing inhibition by castanospermine prevents experimental autoimmune encephalomyelitis by interference with IL-2 receptor signal transduction. J Neuroimmunol 2002 0.80
70 β1-integrin/matrix interactions support blood-brain barrier integrity. J Cereb Blood Flow Metab 2011 0.80
71 Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo. Methods Mol Biol 2010 0.79
72 PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. Eur J Immunol 2014 0.79
73 Transfer of the sFLT-1 gene in Morris hepatoma results in decreased growth and perfusion and induction of genes associated with stress response. Clin Cancer Res 2005 0.79
74 Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS One 2012 0.78
75 Interferon-beta 1b leads to a short-term increase of soluble but long-term stabilisation of cell surface bound adhesion molecules in multiple sclerosis. J Neurol 2004 0.78
76 PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice. J Neuroimmunol 2010 0.78
77 The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell Tissue Res 2014 0.78
78 Angiostatin overexpression in Morris hepatoma results in decreased tumor growth but increased perfusion and vascularization. J Nucl Med 2006 0.78
79 The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. Cell Physiol Biochem 2006 0.78
80 PSGL-1--the hidden player in T cell trafficking into the brain in multiple sclerosis? J Leukoc Biol 2009 0.77
81 DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation. Brain 2014 0.77
82 Therapeutic targeting of leukocyte trafficking across the blood-brain barrier. Inflamm Allergy Drug Targets 2007 0.76