Published in Eur J Immunol on September 01, 2010
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. Arthritis Res Ther (2012) 0.92
Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels. J Immunol (2015) 0.80
A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol (2014) 0.80
Bruton's tyrosine kinase (Btk) is a useful marker for Hodgkin and B cell non-Hodgkin lymphoma. Virchows Arch (2014) 0.79
The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy. Expert Rev Clin Immunol (2016) 0.77
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol (2012) 2.62
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility. J Immunol (2011) 2.44
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum (2005) 2.32
Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res (2007) 2.32
The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J Exp Med (2003) 2.21
Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing. Immunity (2007) 1.92
A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med (2013) 1.87
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
Consolidative dendritic cell-based immunotherapy elicits cytotoxicity against malignant mesothelioma. Am J Respir Crit Care Med (2010) 1.60
The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57
CTCF regulates cell cycle progression of alphabeta T cells in the thymus. EMBO J (2008) 1.55
Mild versus strong anti-inflammatory therapy during early sepsis in mice: a matter of life and death. Crit Care Med (2011) 1.44
COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function. BMC Cancer (2010) 1.43
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med (2013) 1.42
The β-human chorionic gonadotropin-related peptide LQGV reduces mortality and inflammation in a murine polymicrobial sepsis model. Crit Care Med (2011) 1.42
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood (2009) 1.42
Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol (2008) 1.36
Gata3 drives development of RORγt+ group 3 innate lymphoid cells. J Exp Med (2014) 1.36
Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A (2013) 1.34
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. EMBO J (2004) 1.22
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol (2012) 1.21
Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis. Rheumatology (Oxford) (2011) 1.15
Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol (2009) 1.14
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. Hum Mol Genet (2002) 1.10
Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo. Cell Cycle (2014) 1.10
Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J Exp Med (2003) 1.10
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity (2012) 1.09
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. DNA Repair (Amst) (2006) 1.03
A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics. Eur J Immunol (2002) 1.03
Local and systemic cytokine profiles in nonsevere and severe community-acquired pneumonia. Eur Respir J (2012) 1.03
Bruton's tyrosine kinase mediated signaling enhances leukemogenesis in a mouse model for chronic lymphocytic leukemia. Am J Blood Res (2013) 1.02
Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer. Oncotarget (2010) 1.01
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice. Blood (2012) 1.01
Analysis of mouse Rad54 expression and its implications for homologous recombination. DNA Repair (Amst) (2002) 1.00
Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. J Immunol (2003) 0.99
Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding. J Neurosci (2011) 0.99
Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood (2003) 0.99
Differentiation driven changes in the dynamic organization of Basal transcription initiation. PLoS Biol (2009) 0.99
Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells. Nucleic Acids Res (2013) 0.98
Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. Immunity (2007) 0.98
Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease. Mol Cell Endocrinol (2011) 0.98
Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice. J Immunol (2002) 0.97
GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum (2009) 0.96
Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes. Mol Immunol (2008) 0.96
Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis. Arthritis Rheum (2010) 0.96
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. DNA Repair (Amst) (2011) 0.94
The pre-BCR checkpoint as a cell-autonomous proliferation switch. Trends Immunol (2004) 0.94
Granuloma formation in pulmonary sarcoidosis. Front Immunol (2013) 0.93
Tagged mutagenesis by efficient Minos-based germ line transposition. Mol Cell Biol (2010) 0.93
Systemic CD4+ and CD8+ T-cell cytokine profiles correlate with GOLD stage in stable COPD. Eur Respir J (2011) 0.93
Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors. J Exp Med (2004) 0.93
The intrathymic crossroads of T and NK cell differentiation. Immunol Rev (2010) 0.93
Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet (2011) 0.93
Drug discovery: New Btk inhibitor holds promise. Nat Chem Biol (2011) 0.92
DNA-binding factor CTCF and long-range gene interactions in V(D)J recombination and oncogene activation. Blood (2012) 0.92
GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol (2007) 0.91
Type 2 innate lymphocytes in allergic airway inflammation. Curr Allergy Asthma Rep (2013) 0.91
Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. Cell Signal (2011) 0.89
Aberrant B cell selection and activation in systemic lupus erythematosus. Int Rev Immunol (2013) 0.88
Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther (2013) 0.88
Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells. Cell Signal (2008) 0.88
Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One (2012) 0.87
Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer. PLoS One (2012) 0.87
Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice. J Immunol (2009) 0.87
Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol (2008) 0.87
Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway. Blood (2009) 0.87
Group 2 innate lymphoid cells in lung inflammation. Immunology (2013) 0.86
Generation of heavy-chain-only antibodies in mice. Proc Natl Acad Sci U S A (2006) 0.86
Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis. Arthritis Rheumatol (2014) 0.86
Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity. Blood (2004) 0.85
Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement. J Immunol (2006) 0.84
Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. PLoS Genet (2013) 0.84
T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia. Thorax (2013) 0.84
The complement system facilitates clearance of Enterococcus faecium during murine peritonitis. J Infect Dis (2010) 0.84
Enforced expression of Gata3 in T cells and group 2 innate lymphoid cells increases susceptibility to allergic airway inflammation in mice. J Immunol (2014) 0.83
The neonatal Fc receptor is expressed by human retinal pigment epithelial cells and is downregulated by tumour necrosis factor-alpha. Br J Ophthalmol (2011) 0.83
Platelet-derived growth factor-BB: a stimulus for cytokine production by orbital fibroblasts in Graves' ophthalmopathy. Invest Ophthalmol Vis Sci (2009) 0.83
Low-dose cyclophosphamide synergizes with dendritic cell-based immunotherapy in antitumor activity. J Biomed Biotechnol (2010) 0.83
Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest Ophthalmol Vis Sci (2009) 0.83
The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β. PLoS One (2013) 0.82
Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes. Mol Immunol (2009) 0.82
Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation. Blood (2007) 0.81
Evidence for local dendritic cell activation in pulmonary sarcoidosis. Respir Res (2012) 0.81
A mouse model for endometrioid ovarian cancer arising from the distal oviduct. Int J Cancer (2014) 0.81
Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation. Mol Immunol (2011) 0.81