Published in J Control Release on July 18, 2010
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med (2011) 1.74
The role and therapeutic potential of prohibitin in disease. Biochim Biophys Acta (2011) 1.32
Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. J Control Release (2010) 1.27
Combinatorial peptide libraries: mining for cell-binding peptides. Chem Rev (2013) 1.07
Dynamic factors controlling targeting nanocarriers to vascular endothelium. Curr Drug Metab (2012) 1.02
A review on composite liposomal technologies for specialized drug delivery. J Drug Deliv (2011) 1.00
Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation. J Nanotechnol Eng Med (2013) 0.95
Multifaceted role of prohibitin in cell survival and apoptosis. Apoptosis (2015) 0.86
A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem (2014) 0.85
Selection of aptamers specific for adipose tissue. PLoS One (2012) 0.81
Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain. Int J Nanomedicine (2014) 0.80
Inhibition of the CRAF/prohibitin interaction reverses CRAF-dependent resistance to vemurafenib. Oncogene (2016) 0.80
Therapeutic assessment of cytochrome C for the prevention of obesity through endothelial cell-targeted nanoparticulate system. Mol Ther (2013) 0.77
Ligand-targeted theranostic nanomedicines against cancer. J Control Release (2016) 0.77
A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes. PLoS One (2015) 0.75
STING is a direct innate immune sensor of cyclic di-GMP. Nature (2011) 6.44
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Proc Natl Acad Sci U S A (2006) 4.33
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun (2010) 3.89
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev (2006) 3.71
A cyclic-di-GMP receptor required for bacterial exopolysaccharide production. Mol Microbiol (2007) 3.54
The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa. Mol Microbiol (2007) 3.11
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep (2013) 3.08
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med (2009) 2.92
Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic di-GMP. J Bacteriol (2006) 2.15
Bacterial c-di-GMP is an immunostimulatory molecule. J Immunol (2007) 2.13
Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment. AAPS J (2009) 1.99
Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen. Genes Dev (2009) 1.82
A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev (2010) 1.76
High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem (2005) 1.67
The monocyte chemotactic protein-1 gene may contribute to hypertension in Dahl salt-sensitive rats. Hypertens Res (2007) 1.47
Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes. J Control Release (2009) 1.44
c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation. Antimicrob Agents Chemother (2005) 1.32
Liposome clearance. Biosci Rep (2002) 1.25
Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc (2006) 1.24
Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther (2005) 1.23
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. Hepatology (2005) 1.19
Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. Acc Chem Res (2011) 1.18
Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid. J Biol Chem (2006) 1.16
Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape. J Biol Chem (2008) 1.15
Cyclic di-GMP stimulates protective innate immunity in bacterial pneumonia. Infect Immun (2007) 1.15
Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system. Adv Drug Deliv Rev (2007) 1.12
Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. Int J Pharm (2006) 1.10
The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic Di-GMP in host cell infection. J Bacteriol (2008) 1.09
Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials (2011) 1.09
3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun (2005) 1.07
Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. J Biochem (2002) 1.07
Octaarginine-modified multifunctional envelope-type nano device for siRNA. J Control Release (2007) 1.07
Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery. J Control Release (2011) 1.07
Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization. Arch Biochem Biophys (2003) 1.07
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep (2003) 1.06
A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J Control Release (2009) 1.06
Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process. Biomaterials (2009) 1.05
Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. Biomaterials (2011) 1.05
Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. Mol Ther (2013) 1.03
Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method. J Control Release (2004) 1.03
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. J Control Release (2012) 1.02
Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. Biochemistry (2004) 1.02
3',5'-cyclic diguanylic acid reduces the virulence of biofilm-forming Staphylococcus aureus strains in a mouse model of mastitis infection. Antimicrob Agents Chemother (2005) 1.01
No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA. Bioconjug Chem (2003) 1.01
Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis. Biochem Pharmacol (2004) 1.01
Learning from the viral journey: how to enter cells and how to overcome intracellular barriers to reach the nucleus. AAPS J (2009) 1.01
Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex. Nucleic Acids Res (2007) 1.00
New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX. Nucleic Acids Res (2005) 1.00
Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes. Biochem Biophys Res Commun (2010) 0.99
Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation. J Control Release (2010) 0.99
Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria. Mitochondrion (2006) 0.99
Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli. J Bacteriol (2006) 0.99
Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev (2008) 0.99
Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. Drug Metab Dispos (2006) 0.99
RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells. FEBS Lett (2005) 0.99
The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. Biol Pharm Bull (2013) 0.98
Polymorphism of CYP11B2 determines salt sensitivity in Japanese. Hypertension (2007) 0.98
Lipoplex size determines lipofection efficiency with or without serum. Mol Membr Biol (2003) 0.98
Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature. Biochim Biophys Acta (2006) 0.97
MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim Biophys Acta (2007) 0.97
Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. Int J Pharm (2004) 0.96
c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection. Vaccine (2009) 0.96
Biochemical and physiological characterization of a BLUF protein-EAL protein complex involved in blue light-dependent degradation of cyclic diguanylate in the purple bacterium Rhodopseudomonas palustris. Biochemistry (2010) 0.94
Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am J Physiol Gastrointest Liver Physiol (2006) 0.94
Pharmacokinetic and pharmacodynamic considerations in gene therapy. Drug Discov Today (2003) 0.94
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Free Radic Biol Med (2010) 0.94
Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes. Pharm Res (2002) 0.94
Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues. J Immunol Methods (2010) 0.93
Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score. FEBS Lett (2005) 0.93
Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots. J Phys Chem B (2008) 0.93
An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal Bioanal Chem (2008) 0.93
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine (2008) 0.93
Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system. Mol Ther (2013) 0.93
Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol (2002) 0.93
Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes. Mol Ther (2008) 0.93
Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. J Control Release (2006) 0.92