PubRank

Hidetaka Akita

Author PubWeight™ 68.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006 3.71
2 A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 2010 1.76
3 Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc 2006 1.24
4 Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther 2005 1.23
5 Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. Hepatology 2005 1.19
6 Efficient intracellular delivery of nucleic acid pharmaceuticals using cell-penetrating peptides. Acc Chem Res 2011 1.18
7 Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system. Adv Drug Deliv Rev 2007 1.12
8 Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials 2011 1.09
9 A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J Control Release 2009 1.06
10 Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. Biomaterials 2011 1.05
11 A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. J Control Release 2012 1.02
12 Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex. Nucleic Acids Res 2007 1.00
13 Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria. Mitochondrion 2006 0.99
14 Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs. Drug Metab Dispos 2006 0.99
15 The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. Biol Pharm Bull 2013 0.98
16 Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature. Biochim Biophys Acta 2006 0.97
17 MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim Biophys Acta 2007 0.97
18 Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo. Int J Pharm 2004 0.96
19 Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue. J Control Release 2010 0.95
20 Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am J Physiol Gastrointest Liver Physiol 2006 0.94
21 Pharmacokinetic and pharmacodynamic considerations in gene therapy. Drug Discov Today 2003 0.94
22 Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues. J Immunol Methods 2010 0.93
23 Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score. FEBS Lett 2005 0.93
24 Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots. J Phys Chem B 2008 0.93
25 Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system. Mol Ther 2013 0.93
26 Supramolecular control of polyplex dissociation and cell transfection: efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes. J Control Release 2008 0.90
27 A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids. Int J Pharm 2005 0.89
28 Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology 2004 0.89
29 Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes. Int J Pharm 2007 0.88
30 Pharmacokinetics and brain uptake of lactoferrin in rats. Life Sci 2005 0.88
31 Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape. J Control Release 2009 0.87
32 Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nuclei. Nat Protoc 2006 0.86
33 Non-linear pharmacodynamics in a non-viral gene delivery system: positive non-linear relationship between dose and transfection efficiency. J Control Release 2005 0.86
34 Autopsy cases of fulminant-type bacterial infection with necrotizing fasciitis: group A (beta) hemolytic Streptococcus pyogenes versus Vibrio vulnificus infection. Pathol Int 2008 0.85
35 Multifunctional envelope-type nano device for non-viral gene delivery: concept and application of Programmed Packaging. J Control Release 2007 0.85
36 Cell penetrating peptide-mediated systemic siRNA delivery to the liver. Int J Pharm 2011 0.85
37 Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system. Biol Pharm Bull 2009 0.84
38 A DNA microarray-based analysis of the host response to a nonviral gene carrier: a strategy for improving the immune response. Mol Ther 2011 0.84
39 RNA interference-based silencing reveals the regulatory role of fatty acid-binding protein 4 in the production of IL-6 and vascular endothelial growth factor in 3T3-L1 adipocytes. Endocrinology 2012 0.84
40 A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway. J Control Release 2007 0.83
41 Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol 2004 0.83
42 Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure. Biol Pharm Bull 2005 0.83
43 FRET from quantum dots to photodecompose undesired acceptors and report the condensation and decondensation of plasmid DNA. ACS Nano 2012 0.82
44 Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium. ACS Nano 2013 0.82
45 Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus. Biol Pharm Bull 2006 0.82
46 Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET. Nucleic Acids Res 2011 0.82
47 Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system. Biomaterials 2007 0.82
48 Improvement of doxorubicin efficacy using liposomal anti-polo-like kinase 1 siRNA in human renal cell carcinomas. Mol Pharm 2014 0.82
49 Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis. Biochem Biophys Res Commun 2010 0.81
50 Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. Chembiochem 2005 0.80
51 Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription. Biomaterials 2009 0.80
52 Comparison between a multifunctional envelope-type nano device and lipoplex for delivery to the liver. Biol Pharm Bull 2010 0.79
53 Oligosaccharide-mediated nuclear transport of nanoparticles. Chembiochem 2008 0.79
54 Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery. J Control Release 2012 0.79
55 Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery. J Control Release 2009 0.79
56 KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine. Biomaterials 2011 0.79
57 Stearylated INF7 peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo. J Pharm Sci 2011 0.79
58 2-Methacryloyloxyethyl phosphorylcholine polymer (MPC)-coating improves the transfection activity of GALA-modified lipid nanoparticles by assisting the cellular uptake and intracellular dissociation of plasmid DNA in primary hepatocytes. Biomaterials 2010 0.78
59 A novel nonviral gene delivery system: multifunctional envelope-type nano device. Adv Biochem Eng Biotechnol 2010 0.78
60 Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells. Int J Pharm 2009 0.78
61 In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP). Biol Pharm Bull 2007 0.78
62 [A case of Stage IV gastric cancer was successfully treated with multi combination chemotherapy with S-1]. Gan To Kagaku Ryoho 2014 0.78
63 Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells. Biol Pharm Bull 2006 0.78
64 Functional improvement of an IRQ-PEG-MEND for delivering genes to the lung. J Control Release 2011 0.77
65 Clinicopathological findings in fulminant-type pneumococcal infection: report of three autopsy cases. Pathol Int 2007 0.77
66 Therapeutic assessment of cytochrome C for the prevention of obesity through endothelial cell-targeted nanoparticulate system. Mol Ther 2013 0.77
67 Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice. Drug Metab Pharmacokinet 2005 0.77
68 Effect of the anchor in polyethylene glycol-lipids on the transfection activity of PEGylated cationic liposomes encapsulating DNA. Biol Pharm Bull 2012 0.76
69 Accumulation of O-GlcNAc-displaying CdTe quantum dots in cells in the presence of ATP. Chembiochem 2007 0.76
70 Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system. Adv Healthc Mater 2014 0.76
71 Effect of polyethyleneglycol spacer on the binding properties of nuclear localization signal-modified liposomes to isolated nucleus. Biol Pharm Bull 2009 0.76
72 Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem 2006 0.76
73 Pretreatment of hepatocyte growth factor gene transfer mediated by octaarginine peptide-modified nanoparticles ameliorates LPS/D-galactosamine-induced hepatitis. Nucleic Acid Ther 2012 0.75
74 Multifunctional envelope-type nano device (MEND) for organelle targeting via a stepwise membrane fusion process. Methods Enzymol 2012 0.75
75 A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication. J Control Release 2013 0.75
76 [A case of liver metastasis from sigmoid colon cancer treated effectively by second-line chemotherapy]. Gan To Kagaku Ryoho 2014 0.75
77 Reporter gene expression at single-cell level characterized with real-time RT-PCR, chemiluminescence, fluorescence, and electrochemical imaging. FEBS Lett 2010 0.75
78 [Development of an efficient short interference RNA (siRNA) delivery system with a new pH-sensitive cationic lipid]. Yakugaku Zasshi 2012 0.75
79 Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan. Emerg Infect Dis 2020 0.75
80 [Development of various multifunctional envelope-type nano device MEND based on novel assembly technologies]. Yakugaku Zasshi 2008 0.75
81 [Development of multifunctional envelope type artificial viral-like gene delivery system]. Yakugaku Zasshi 2007 0.75
82 [A Study of Therapy for Locally Advanced Breast Cancer with Metastasis]. Gan To Kagaku Ryoho 2016 0.75
83 Sigmoid volvulus is associated with a decrease in enteric plexuses and ganglion cells: a case-control study. Int J Colorectal Dis 2015 0.75
84 [A case of Carboplatin and pemetrexed combination chemotherapy for synchronous double cancers of hepatocellular carcinoma and primary lung cancer]. Gan To Kagaku Ryoho 2014 0.75
85 Production of small nano-sized particles by complex formation between polycations and linearized plasmid DNA at a low pH. J Biosci Bioeng 2013 0.75
86 [Photonics meets sensing of bio-reaction and cell dynamics]. Yakugaku Zasshi 2012 0.75
87 Autopsy cases of miliary tuberculosis: clinicopathologic features including background factors. J Nippon Med Sch 2011 0.75
88 [Envelope-type nano device for gene delivery]. Nihon Rinsho 2006 0.75
89 [A case of primary peritoneal carcinoma successfully treated using Paclitaxel and Carboplatin chemotherapy]. Gan To Kagaku Ryoho 2014 0.75
90 [Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid]. Yakugaku Zasshi 2007 0.75