Published in Fitoterapia on July 23, 2010
Potent effects of dioscin against obesity in mice. Sci Rep (2015) 0.88
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway. Sci Rep (2015) 0.85
A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1. Int J Mol Sci (2013) 0.80
Therapeutic effects of total steroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund's complete adjuvant induced arthritis in rats. Int Immunopharmacol (2014) 0.80
Simultaneous quantification of five steroid saponins from Dioscorea zingiberensis C.H. Wright in rat plasma by HPLC-MS/MS and its application to the pharmacokinetic studies. Steroids (2014) 0.80
Herbal medicines and nonalcoholic fatty liver disease. World J Gastroenterol (2016) 0.79
Preparative isolation and purification of five steroid saponins from Dioscorea zingiberensis C.H.Wright by counter-current chromatography coupled with evaporative light scattering detector. J Pharm Biomed Anal (2013) 0.79
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines. J Biomed Sci (2014) 0.79
The aphrodisiac herb Carpolobia: A biopharmacological and phytochemical review. Pharmacogn Rev (2015) 0.78
Neuroprotective effects of total steroid saponins on cerebral ischemia injuries in an animal model of focal ischemia/reperfusion. Planta Med (2014) 0.76
Comparative studies on performance of CCC and preparative RP-HPLC in separation and purification of steroid saponins from Dioscorea zingiberensis C.H.Wright. J Steroids Horm Sci (2015) 0.75
Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress. Front Pharmacol (2017) 0.75
Potent effects of dioscin against pancreatic cancer via miR-149-3P-mediated inhibition of AKT1 signaling pathway. Br J Pharmacol (2017) 0.75
Dioscin stimulates differentiation of mesenchymal stem cells towards hypertrophic chondrocytes in vitro and endochondral ossification in vivo. Am J Transl Res (2016) 0.75
Protodioscin, Isolated from the Rhizome of Dioscorea tokoro Collected in Northern Japan is the Major Antiproliferative Compound to HL-60 Leukemic Cells. Curr Bioact Compd (2017) 0.75
Gene Expression Profiling associated with Hepatoxicity in Pregnant Rats treated with Ubi Gadong (Dioscorea hispida) Extract. Int J Biomed Sci (2017) 0.75
Protective effects of dioscin against cisplatin-induced nephrotoxicity via regulating miR-34a/Sirt1 signal pathway. Br J Pharmacol (2017) 0.75
Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol (2006) 8.05
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
Nicastrin functions as a gamma-secretase-substrate receptor. Cell (2005) 4.64
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
High-detectivity polymer photodetectors with spectral response from 300 nm to 1450 nm. Science (2009) 2.78
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem (2010) 2.72
Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer (2011) 2.59
TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem (2009) 2.40
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem (2011) 1.88
Endocardial autonomic denervation of the left atrium to treat vasovagal syncope: an early experience in humans. Circ Arrhythm Electrophysiol (2012) 1.81
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem (2003) 1.77
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. Cell Metab (2013) 1.74
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor. Mol Cell Biol (2010) 1.64
Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data. Nephrol Dial Transplant (2012) 1.59
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem (2002) 1.44
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem (2012) 1.43
TDP-43 aggregation in neurodegeneration: are stress granules the key? Brain Res (2012) 1.35
Occurrence of PAHs, PCBs and organochlorine pesticides in the Tonghui River of Beijing, China. Environ Pollut (2004) 1.33
Glu-333 of nicastrin directly participates in gamma-secretase activity. J Biol Chem (2009) 1.30
Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. Biol Psychiatry (2012) 1.27
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem (2002) 1.26
Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease. Curr Alzheimer Res (2008) 1.25
Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog (2010) 1.21
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex. J Biol Chem (2003) 1.19
Polycyclic aromatic hydrocarbons (PAHs) in urban soils of the megacity Shanghai: occurrence, source apportionment and potential human health risk. Sci Total Environ (2013) 1.17
Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants. PLoS Pathog (2011) 1.16
p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol (2007) 1.15
Preliminary evidence for a 1000-year-old tsunami in the South China Sea. Sci Rep (2013) 1.12
Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure. Bone (2008) 1.11
Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med (2011) 1.09
Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity. J Biol Chem (2013) 1.08
Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior. Proc Natl Acad Sci U S A (2012) 1.08
Pharmaceuticals and personal care products in the aquatic environment in China: a review. J Hazard Mater (2013) 1.07
RNA-Seq analysis uncovers transcriptomic variations between morphologically similar in vivo- and in vitro-derived bovine blastocysts. BMC Genomics (2012) 1.07
Rescue of peripheral and CNS axon defects in mice lacking NMNAT2. J Neurosci (2013) 1.07
Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesis. J Tissue Eng Regen Med (2009) 1.07
Production of a bioflocculant by Aspergillus parasiticus and its application in dye removal. Colloids Surf B Biointerfaces (2005) 1.07
Grain protein content variation and its association analysis in barley. BMC Plant Biol (2013) 1.06
Laparoscopy-assisted total gastrectomy with trans-orally inserted anvil (OrVil™): a single institution experience. World J Gastroenterol (2013) 1.03
Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population. Nephrol Dial Transplant (2012) 1.02
Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem (2010) 1.01
Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives. Planta Med (2008) 1.01
Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c. Biochem J (2007) 1.01
Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. Eur J Pharmacol (2009) 1.01
Mutation in the γ2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage. Circ Res (2014) 1.00
Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells. Mol Pharmacol (2008) 0.99
Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents. J Ethnopharmacol (2009) 0.99
Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010. Emerg Infect Dis (2014) 0.98
Particle size: a missing factor in risk assessment of human exposure to toxic chemicals in settled indoor dust. Environ Int (2012) 0.97
Solution structure of the viral receptor domain of Tva and its implications in viral entry. J Virol (2002) 0.96
Development of species sensitivity distributions and estimation of HC(5) of organochlorine pesticides with five statistical approaches. Ecotoxicology (2008) 0.96
An investigation of the treatment of particulate matter from gasoline engine exhaust using non-thermal plasma. J Hazard Mater (2005) 0.95
Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat model. J Orthop Res (2009) 0.95
HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Mol Cell Neurosci (2009) 0.95
Evaluation of x-ray projection angulation for successful radix entomolaris diagnosis in mandibular first molars in vitro. J Endod (2011) 0.94
Modeling adenovirus latency in human lymphocyte cell lines. J Virol (2010) 0.94
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem (2014) 0.93
Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Res (2009) 0.92
Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry (2011) 0.92
3D hierarchical architectures based on self-rolled-up silicon nitride membranes. Nanotechnology (2013) 0.92
Abdominal obesity and the risk of colorectal adenoma: a meta-analysis of observational studies. Eur J Cancer Prev (2012) 0.92
Selective removal of perfluorooctane sulfonate from aqueous solution using chitosan-based molecularly imprinted polymer adsorbents. Water Res (2008) 0.92
Anxiety correlates with somatic symptoms and sleep status at high altitudes. Physiol Behav (2013) 0.91
[Effects of the antibacterial peptide cecropins from Chinese oak silkworm, Antheraea pernyi on 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats]. Di Yi Jun Yi Da Xue Xue Bao (2003) 0.91
Colonization and/or mitochondrial selective sweeps across the North Atlantic intertidal assemblage revealed by multi-taxa approximate Bayesian computation. Mol Ecol (2010) 0.91
Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Dev Psychobiol (2013) 0.91
FeCl(3).6H(2)O catalyzed disproportionation of allylic alcohols and selective allylic reduction of allylic alcohols and their derivatives with benzyl alcohol. J Org Chem (2009) 0.91
Granular activated carbon adsorption and microwave regeneration for the treatment of 2,4,5-trichlorobiphenyl in simulated soil-washing solution. J Hazard Mater (2007) 0.91
Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo. Phytomedicine (2010) 0.89
A novel liquidchip platform for simultaneous detection of 70 alleles of DNA somatic mutations on EGFR, KRAS, BRAF and PIK3CA from formalin-fixed and paraffin-embedded slides containing tumor tissue. Clin Chem Lab Med (2010) 0.89
Clinical survey on contrast-induced nephropathy after coronary angiography. Ren Fail (2013) 0.89
SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile. Org Lett (2007) 0.89
A novel mutation of TGF beta1 in a Chinese family with Camurati-Engelmann disease. Bone (2007) 0.88
Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chem Biol Interact (2010) 0.88
Enhanced adsorption of arsenate on the aminated fibers: sorption behavior and uptake mechanism. Langmuir (2008) 0.88
Production of diosgenin from yellow ginger (Dioscorea zingiberensis C. H. Wright) saponins by commercial cellulase. World J Microbiol Biotechnol (2009) 0.88
In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. Food Chem Toxicol (2011) 0.88
Pigment epithelial-derived factor and melanoma differentiation associated gene-7 cytokine gene therapies delivered by adipose-derived stromal/mesenchymal stem cells are effective in reducing prostate cancer cell growth. Stem Cells Dev (2011) 0.87
Ultrasensitive electrochemical aptasensor for thrombin based on the amplification of aptamer-AuNPs-HRP conjugates. Biosens Bioelectron (2010) 0.87
ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. Biochem Biophys Res Commun (2004) 0.87
Differentiated human adipose-derived stem cells exhibit hepatogenic capability in vitro and in vivo. J Cell Physiol (2010) 0.87
MicroRNA conjugated gold nanoparticles and cell transfection. Anal Chem (2011) 0.87
Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. J Chromatogr A (2008) 0.86
Electrocatalytic hydrodechlorination of 2,4,5-trichlorobiphenyl on a palladium-modified nickel foam cathode. Environ Sci Technol (2007) 0.86
Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. J Neurosci Res (2010) 0.86
ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. Biochem Biophys Res Commun (2006) 0.86
Quantitative structure-property relationships on photodegradation of polybrominated diphenyl ethers. Chemosphere (2005) 0.86
Curcumin prevents cerebral ischemia reperfusion injury via increase of mitochondrial biogenesis. Neurochem Res (2014) 0.86
Transport and fate of organochlorine pesticides in the River Wuchuan, southeast China. J Environ Monit (2002) 0.85
Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway. Inflammation (2014) 0.85
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration. Biol Chem (2012) 0.85
Proteome of human subcutaneous adipose tissue stromal vascular fraction cells versus mature adipocytes based on DIGE. J Proteome Res (2011) 0.85
PET demonstrates functional recovery after transplantation of induced pluripotent stem cells in a rat model of cerebral ischemic injury. J Nucl Med (2013) 0.85
Reproducibility of diffusion tensor imaging in normal subjects: an evaluation of different gradient sampling schemes and registration algorithm. Neuroradiology (2014) 0.85
Metabolic syndrome, C-reactive protein and microalbuminuria in a rural Chinese population: a cross-sectional study. BMC Nephrol (2013) 0.85
sorLA: sorting out APP. Mol Interv (2006) 0.85
Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals. Biol Pharm Bull (2011) 0.85
Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen (2007) 0.84
Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation. Appl Microbiol Biotechnol (2010) 0.84