Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

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Published in J Med Chem on December 03, 2014

Authors

Timothy D Cushing1, Xiaolin Hao, Youngsook Shin, Kristin Andrews, Matthew Brown, Mario Cardozo, Yi Chen, Jason Duquette, Ben Fisher, Felix Gonzalez-Lopez de Turiso, Xiao He, Kirk R Henne, Yi-Ling Hu, Randall Hungate, Michael G Johnson, Ron C Kelly, Brian Lucas, John D McCarter, Lawrence R McGee, Julio C Medina, Tisha San Miguel, Deanna Mohn, Vatee Pattaropong, Liping H Pettus, Andreas Reichelt, Robert M Rzasa, Jennifer Seganish, Andrew S Tasker, Robert C Wahl, Sharon Wannberg, Douglas A Whittington, John Whoriskey, Gang Yu, Leeanne Zalameda, Dawei Zhang, Daniela P Metz

Author Affiliations

1: Department of Therapeutic Discovery, ‡Department of Pharmacokinetics and Drug Metabolism, and §Department of Pharmaceutics Research and Development, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.

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