Published in Proc Natl Acad Sci U S A on July 26, 2010
VLR-based adaptive immunity. Annu Rev Immunol (2012) 1.56
A thymus candidate in lampreys. Nature (2011) 1.44
Evolutionary implications of a third lymphocyte lineage in lampreys. Nature (2013) 1.19
Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores. Structure (2012) 1.06
Organization of lamprey variable lymphocyte receptor C locus and repertoire development. Proc Natl Acad Sci U S A (2013) 0.96
Definition of a third VLR gene in hagfish. Proc Natl Acad Sci U S A (2013) 0.92
Re-evaluation of the immunological Big Bang. Curr Biol (2014) 0.91
A major allogenic leukocyte antigen in the agnathan hagfish. Sci Rep (2013) 0.85
Crystal structure of the lamprey variable lymphocyte receptor C reveals an unusual feature in its N-terminal capping module. PLoS One (2014) 0.85
Purification and identification of cell surface antigens using lamprey monoclonal antibodies. J Immunol Methods (2012) 0.82
The invention of lymphocytes. Curr Opin Immunol (2011) 0.82
Characterization of Lamprey IL-17 Family Members and Their Receptors. J Immunol (2015) 0.78
Lampreys as Diverse Model Organisms in the Genomics Era. Bioscience (2015) 0.78
Evolution of two prototypic T cell lineages. Cell Immunol (2015) 0.78
Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates. Proc Natl Acad Sci U S A (2014) 0.77
Lamprey immunity is far from primitive. Proc Natl Acad Sci U S A (2013) 0.77
The lamprey: a jawless vertebrate model system for examining origin of the neural crest and other vertebrate traits. Differentiation (2014) 0.77
Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates. Curr Genomics (2012) 0.77
Chronic lymphocytic leukemia monitoring with a Lamprey idiotope-specific antibody. Cancer Immunol Res (2013) 0.76
Selection of the lamprey VLRC antigen receptor repertoire. Proc Natl Acad Sci U S A (2014) 0.76
Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins. Plant Methods (2017) 0.75
Non-mammalian model systems for studying neuro-immune interactions after spinal cord injury. Exp Neurol (2014) 0.75
An inhibitory receptor of VLRB in the agnathan lamprey. Sci Rep (2016) 0.75
Identification and characterisation of the immune response properties of Lampetra japonica BLNK. Sci Rep (2016) 0.75
Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae. Sci Rep (2016) 0.75
Biochemical regulatory features of AID remain conserved from lamprey to humans. Mol Cell Biol (2017) 0.75
Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes. Immunogenetics (2014) 0.75
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics (2005) 34.83
MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform (2008) 24.69
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature (2004) 4.37
Diversity and function of adaptive immune receptors in a jawless vertebrate. Science (2005) 3.39
Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. Nat Immunol (2007) 3.14
Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat Rev Genet (2009) 3.11
Reconstructing immune phylogeny: new perspectives. Nat Rev Immunol (2005) 2.95
The evolution of adaptive immune systems. Cell (2006) 2.77
Dual nature of the adaptive immune system in lampreys. Nature (2009) 2.53
The evolution of adaptive immunity. Annu Rev Immunol (2006) 2.32
Variable lymphocyte receptors in hagfish. Proc Natl Acad Sci U S A (2005) 1.99
Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem (2006) 1.89
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nat Immunol (2006) 1.89
Antibody responses of variable lymphocyte receptors in the lamprey. Nat Immunol (2008) 1.87
THE EVOLUTION OF THE IMMUNE RESPONSE. 3. IMMUNOLOGIC RESPONSES IN THE LAMPREY. J Exp Med (1964) 1.75
Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A (2008) 1.74
Phylogenetic origins of antibody structure. 3. Antibodies in the primary immune response of the sea lamprey, Petromyzon marinus. J Exp Med (1968) 1.70
Antigen recognition by variable lymphocyte receptors. Science (2008) 1.61
Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol (2009) 1.55
High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proc Natl Acad Sci U S A (2009) 1.35
The evolution of the immune response. VII. Antibody to human "O" cells and properties of the immunoglobulin in lamprey. J Immunol (1970) 1.32
The evolution of the immune response. VIII. Structural studies of the lamprey immuoglobulin. J Immunol (1970) 1.21
Immunoglobulins and transferrin in marine lamprey sera. Nature (1967) 1.11
Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors. J Immunol (2005) 1.03
Immunologic responses of Pacific hagfish. 3. Serum antibodies to cellular antigens. J Immunol (1970) 1.03
Regulation of antigen-receptor gene assembly in hagfish. EMBO Rep (2010) 1.03
How did our complex immune system evolve? Nat Rev Immunol (2010) 0.92
Two variable lymphocyte receptor genes of the inshore hagfish are located far apart on the same chromosome. Immunogenetics (2007) 0.89
Two types of antigen receptor systems in vertebrates. Zoolog Sci (2008) 0.88
Immunity in lamprey. II. Antigen-binding responses to sheep erythrocytes and hapten in the ammocoete. Dev Comp Immunol (1979) 0.81
One problem, two solutions. Nat Immunol (2009) 0.81
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat Rev Genet (2009) 3.11
The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04
Variable lymphocyte receptors in hagfish. Proc Natl Acad Sci U S A (2005) 1.99
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity (2004) 1.93
Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem (2006) 1.89
Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol (2009) 1.82
Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: "waiting for Godot". Immunogenetics (2003) 1.75
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells. J Exp Med (2008) 1.58
VLR-based adaptive immunity. Annu Rev Immunol (2012) 1.56
A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47
Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat Struct Mol Biol (2008) 1.45
Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Mol Cell (2006) 1.37
Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways. J Biol Chem (2001) 1.34
Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol (2008) 1.31
Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. J Histochem Cytochem (2012) 1.29
Natural killer T cells accelerate atherogenesis in mice. Blood (2004) 1.28
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathog (2006) 1.24
Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection. J Infect Dis (2006) 1.22
Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS One (2012) 1.21
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation. J Exp Med (2010) 1.20
Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. J Virol (2006) 1.09
Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am J Pathol (2011) 1.08
GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1. J Virol (2006) 1.07
Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. Virchows Arch (2003) 1.07
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells. Mol Immunol (2008) 1.05
Natural killer cell receptors in the horse: evidence for the existence of multiple transcribed LY49 genes. Eur J Immunol (2004) 1.05
Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate. J Leukoc Biol (2006) 1.05
Transcriptome analysis of hagfish leukocytes: a framework for understanding the immune system of jawless fishes. Dev Comp Immunol (2004) 1.04
Activation of extracellular signal-related kinase by TNF-alpha controls the maturation and function of murine dendritic cells. J Leukoc Biol (2002) 1.04
Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X. Immunogenetics (2003) 1.03
Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors. J Immunol (2005) 1.03
Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells. Immunol Res (2007) 0.98
Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex. Immunogenetics (2003) 0.98
Corticomedullary differentiation and maturational arrest in thymomas. Histopathology (2013) 0.97
Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A (2008) 0.97
IL-21 enhances dendritic cell ability to induce interferon-gamma production by natural killer T cells. Immunobiology (2007) 0.96
Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol (2003) 0.95
Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism. J Immunol (2008) 0.95
Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathways. Immunol Lett (2012) 0.94
Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like. Immunogenetics (2006) 0.92
CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J Immunol (2011) 0.91
Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J Immunol (2012) 0.91
Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype. Mol Hum Reprod (2005) 0.90
Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J Biol Chem (2003) 0.90
No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage. Hum Reprod (2004) 0.90
Two variable lymphocyte receptor genes of the inshore hagfish are located far apart on the same chromosome. Immunogenetics (2007) 0.89
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype. Blood (2005) 0.89
Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals. Immunogenetics (2005) 0.89
Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion. Biol Reprod (2007) 0.89
Xenopus class II A genes: studies of genetics, polymorphism, and expression. Dev Comp Immunol (2002) 0.89
Phylogenetic and expression analysis of lamprey toll-like receptors. Dev Comp Immunol (2010) 0.88
Two types of antigen receptor systems in vertebrates. Zoolog Sci (2008) 0.88
Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex. Blood (2009) 0.88
Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells. Immunol Lett (2003) 0.87
The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45. Immunogenetics (2002) 0.87
Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions. Blood (2005) 0.87
Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage. Am J Reprod Immunol (2006) 0.86
Clonotypic analysis of T cells accumulating at arthritic lesions in HTLV-I env-pX transgenic rats. Exp Mol Pathol (2002) 0.86
Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Graefes Arch Clin Exp Ophthalmol (2007) 0.86
Intravenous immunoglobulin treatment in women with recurrent abortions: increased cytokine levels and reduced Th1/Th2 lymphocyte ratio in peripheral blood. Am J Reprod Immunol (2003) 0.86
Tumour necrosis factor-alpha but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation. Immunology (2003) 0.86
Screening ultrasonography is useful for the diagnosis of gastric and colorectal cancer. Hepatogastroenterology (2013) 0.86
Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells. Cell Immunol (2009) 0.86
Prostanoid induces premetastatic niche in regional lymph nodes. J Clin Invest (2014) 0.85
Selective regulation of CD40 expression in murine dendritic cells by thiol antioxidants. Immunology (2003) 0.85
Construction of a bacterial artificial chromosome library from the inshore hagfish, Eptatretus burgeri: A resource for the analysis of the agnathan genome. Genes Genet Syst (2004) 0.84
Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Int J Mol Med (2008) 0.84
The role of tumor necrosis factor-α for interleukin-10 production by murine dendritic cells. Cell Immunol (2010) 0.84
Images in cardiovascular medicine: Imaging of cardiac sarcoid lesions using fasting cardiac 18F-fluorodeoxyglucose positron emission tomography: an autopsy case. Circulation (2010) 0.84
In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer. FASEB J (2008) 0.84
The characteristics of human NKT cells in lung cancer--CD1d independent cytotoxicity against lung cancer cells by NKT cells and decreased human NKT cell response in lung cancer patients. Hum Immunol (2004) 0.84
Effects of histamine on functional maturation of dendritic cells. Immunobiology (2003) 0.84
Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus. Intern Med (2014) 0.84
Co-operative action of interleukin-10 and interferon-gamma to regulate dendritic cell functions. Immunology (2008) 0.83
Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice. Circ Res (2012) 0.83
A degenerate ParaHox gene cluster in a degenerate vertebrate. Mol Biol Evol (2007) 0.83
Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation. Lab Invest (2012) 0.83
Osteopontin aggravates experimental autoimmune uveoretinitis in mice. J Immunol (2007) 0.83
Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution. Immunogenetics (2010) 0.83
Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{kappa}B Inhibitor dehydroxy methyl epoxyquinomicin in mice. Invest Ophthalmol Vis Sci (2009) 0.82
Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice. PLoS Negl Trop Dis (2012) 0.82
Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes. Cytometry A (2011) 0.82
Characterization of NKT-cell hybridomas expressing invariant T-cell antigen receptors. J Clin Exp Hematop (2007) 0.82
Functional alteration of peripheral CD25(+)CD4(+)immunoregulatory T cells in a transgenic rat model of autoimmune diseases. J Autoimmun (2003) 0.82
Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. Immunobiology (2006) 0.82
Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice. Immunobiology (2012) 0.82
Comparative genomics of the Mill family: a rapidly evolving MHC class I gene family. Eur J Immunol (2004) 0.81
Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes. Immunogenetics (2011) 0.81
Larval antigen molecules recognized by adult immune cells of inbred Xenopus laevis: partial characterization and implication in metamorphosis. Dev Growth Differ (2002) 0.81
Activation of invariant natural killer T cells by α-galactosylceramide ameliorates myocardial ischemia/reperfusion injury in mice. J Mol Cell Cardiol (2013) 0.81