Published in Arthritis Rheum on November 01, 2010
Inflammation in osteoarthritis. Curr Opin Rheumatol (2011) 2.72
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis (2012) 1.23
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. J Biol Chem (2011) 1.04
Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther (2012) 0.89
Silencing of miR-101 Prevents Cartilage Degradation by Regulating Extracellular Matrix-related Genes in a Rat Model of Osteoarthritis. Mol Ther (2015) 0.82
Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions. Tissue Eng Part A (2014) 0.77
Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog (2016) 0.77
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biol Open (2012) 0.77
New developments in the treatment of osteoarthritis - focus on biologic agents. Open Access Rheumatol (2015) 0.75
SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes. Korean J Intern Med (2014) 0.75
Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem (2016) 0.75
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature (2005) 4.24
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther (2008) 1.43
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest (2007) 1.32
Proteoglycan degradation by the ADAMTS family of proteinases. Biochim Biophys Acta (2011) 1.20
Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum (2007) 1.17
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis Rheum (2005) 1.09
Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis? Curr Drug Targets (2010) 1.09
The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases. Biochem J (2002) 1.05
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem (2002) 1.02
Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nat Protoc (2011) 1.02
Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5. Arthritis Rheum (2008) 0.99
Transparency Is the Key to Quality. J Biol Chem (2015) 0.99
Proteomic characterization of mouse cartilage degradation in vitro. Arthritis Rheum (2008) 0.96
Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum (2013) 0.96
Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis. Arthritis Rheum (2009) 0.94
Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Mol Cell Biol (2005) 0.91
The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan. Arthritis Rheum (2006) 0.90
Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung. Am J Physiol Regul Integr Comp Physiol (2007) 0.87
Reduction of arthritis severity in protease-activated receptor-deficient mice. Arthritis Rheum (2005) 0.87
Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neoepitope during dialysis. Matrix Biol (2002) 0.87
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. J Biol Chem (2007) 0.86
Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44. J Biol Chem (2010) 0.86
Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods Mol Biol (2010) 0.85
Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2. Arthritis Rheumatol (2015) 0.83
N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity. J Biol Chem (2005) 0.82
Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens. J Immunol (2013) 0.82
Local recall responses in the stomach involving reduced regulation and expanded help mediate vaccine-induced protection against Helicobacter pylori in mice. Eur J Immunol (2010) 0.80
Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice. J Biol Chem (2007) 0.79
Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep. J Physiol (2003) 0.77
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biol Open (2012) 0.77
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus. Arthritis Rheum (2012) 0.76
Erratum. J Clin Invest (2008) 0.75