Published in Proc Natl Acad Sci U S A on July 27, 2010
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Structural phylogenomics retrodicts the origin of the genetic code and uncovers the evolutionary impact of protein flexibility. PLoS One (2013) 0.97
The phylogenomic roots of modern biochemistry: origins of proteins, cofactors and protein biosynthesis. J Mol Evol (2012) 0.97
Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis. Nucleic Acids Res (2011) 0.94
Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation. J Exp Bot (2011) 0.92
Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. J Am Chem Soc (2012) 0.82
Bridging the gap between ribosomal and nonribosomal protein synthesis. Proc Natl Acad Sci U S A (2010) 0.81
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Homocysteine Editing, Thioester Chemistry, Coenzyme A, and the Origin of Coded Peptide Synthesis †. Life (Basel) (2017) 0.75
Deep Sequencing of Suppression Subtractive Hybridisation Drought and Recovery Libraries of the Non-model Crop Trifolium repens L. Front Plant Sci (2017) 0.75
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ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry (2002) 1.61
Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases. Methods (2008) 1.46
The ubiquitous carrier protein--a window to metabolite biosynthesis. Nat Prod Rep (2007) 1.44
Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain. Chem Biol (2006) 1.42
When contemporary aminoacyl-tRNA synthetases invent their cognate amino acid metabolism. Proc Natl Acad Sci U S A (2003) 1.40
Investigations of valanimycin biosynthesis: elucidation of the role of seryl-tRNA. Proc Natl Acad Sci U S A (2008) 1.28
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. FEBS J (2005) 1.21
Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition. EMBO J (2006) 1.16
Exploring the domain structure of modular nonribosomal peptide synthetases. Structure (2001) 1.12
A view into the origin of life: aminoacyl-tRNA synthetases. Cell Mol Life Sci (2000) 1.08
Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141. Chembiochem (2006) 1.08
tRNA as an active chemical scaffold for diverse chemical transformations. FEBS Lett (2010) 1.05
Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother (2009) 0.99
Rhizobial acyl carrier proteins and their roles in the formation of bacterial cell-surface components that are required for the development of nitrogen-fixing root nodules on legume hosts. FEMS Microbiol Lett (2002) 0.97
Aminoacyl-tRNAs, the bacterial cell envelope, and antibiotics. Proc Natl Acad Sci U S A (2008) 0.97
Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. Biochimie (2005) 0.95
Regulation of RNA function by aminoacylation and editing? Trends Genet (2004) 0.95
Aminoacylation of coenzyme A and pantetheine by aminoacyl-tRNA synthetases: possible link between noncoded and coded peptide synthesis. Biochemistry (1998) 0.91
Idiosyncratic helix-turn-helix motif in Methanosarcina barkeri seryl-tRNA synthetase has a critical architectural role. J Biol Chem (2009) 0.84
Shuffling of discrete tRNASer regions reveals differently utilized identity elements in yeast and methanogenic archaea. J Mol Biol (2006) 0.83
Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition. FEBS J (2008) 0.81
Identification of amino acids in the N-terminal domain of atypical methanogenic-type Seryl-tRNA synthetase critical for tRNA recognition. J Biol Chem (2009) 0.81
Selective inhibition of divergent seryl-tRNA synthetases by serine analogues. FEBS Lett (2005) 0.80
Amino acid selectivity in the aminoacylation of coenzyme A and RNA minihelices by aminoacyl-tRNA synthetases. J Biol Chem (2000) 0.80
Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1. Science (2010) 4.81
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand. Science (2006) 3.24
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins. Nat Struct Mol Biol (2009) 3.21
The crystal structure of a mammalian fatty acid synthase. Science (2008) 3.12
Structure of the E. coli protein-conducting channel bound to a translating ribosome. Nature (2005) 3.10
The structures of four macrolide antibiotics bound to the large ribosomal subunit. Mol Cell (2002) 3.07
Architecture of mammalian fatty acid synthase at 4.5 A resolution. Science (2006) 3.07
Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6. Science (2011) 2.71
L23 protein functions as a chaperone docking site on the ribosome. Nature (2002) 2.68
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Nature (2004) 2.41
Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Science (2012) 2.34
Architecture of a fungal fatty acid synthase at 5 A resolution. Science (2006) 2.20
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase. Science (2007) 1.96
Structure of fungal fatty acid synthase and implications for iterative substrate shuttling. Science (2007) 1.88
The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature (2009) 1.84
Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB. Nature (2003) 1.76
Structure of the E. coli signal recognition particle bound to a translating ribosome. Nature (2006) 1.74
Multiple conformational switches in a GTPase complex control co-translational protein targeting. Proc Natl Acad Sci U S A (2009) 1.71
Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements. Mol Cell (2006) 1.57
Cryo-EM structure of the archaeal 50S ribosomal subunit in complex with initiation factor 6 and implications for ribosome evolution. J Mol Biol (2012) 1.46
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc Natl Acad Sci U S A (2003) 1.46
Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors. EMBO J (2004) 1.42
Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. EMBO J (2008) 1.41
The crystal structure of the signal recognition particle in complex with its receptor. Science (2011) 1.41
The multienzyme architecture of eukaryotic fatty acid synthases. Curr Opin Struct Biol (2008) 1.38
Structural basis of thiamine pyrophosphate analogues binding to the eukaryotic riboswitch. J Am Chem Soc (2008) 1.36
YidC and Oxa1 form dimeric insertion pores on the translating ribosome. Mol Cell (2009) 1.36
Structural basis of enzyme encapsulation into a bacterial nanocompartment. Nat Struct Mol Biol (2008) 1.36
Atomic structures of the eukaryotic ribosome. Trends Biochem Sci (2012) 1.34
Generation of ribosome nascent chain complexes for structural and functional studies. J Struct Biol (2007) 1.30
Dynamics of trigger factor interaction with translating ribosomes. J Biol Chem (2007) 1.28
The structural basis of autotransporter translocation by TamA. Nat Struct Mol Biol (2013) 1.20
Structure and functional analysis of the fungal galectin CGL2. Structure (2004) 1.20
Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor. Nat Struct Mol Biol (2010) 1.17
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain. FEBS Lett (2007) 1.17
Strategies for crystallization and structure determination of very large macromolecular assemblies. Curr Opin Struct Biol (2007) 1.16
Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition. EMBO J (2006) 1.16
A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature (2008) 1.16
The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A. Nat Struct Mol Biol (2013) 1.13
Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs. Curr Opin Struct Biol (2004) 1.13
Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit. Nat Struct Mol Biol (2012) 1.12
The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059. J Mol Biol (2004) 1.12
A cradle for new proteins: trigger factor at the ribosome. Curr Opin Struct Biol (2005) 1.11
Structure and function of eukaryotic fatty acid synthases. Q Rev Biophys (2010) 1.08
The chemistry of protein synthesis and voyage through the ribosomal tunnel. Curr Opin Struct Biol (2003) 1.08
Evolution of a designed retro-aldolase leads to complete active site remodeling. Nat Chem Biol (2013) 1.07
Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis. J Biol Chem (2012) 1.07
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions. Structure (2008) 1.04
A large hinge bending domain rotation is necessary for the catalytic function of Escherichia coli 5'-nucleotidase. Biochemistry (2005) 1.00
The unusual methanogenic seryl-tRNA synthetase recognizes tRNASer species from all three kingdoms of life. Eur J Biochem (2004) 0.98
Trapping a 96 degrees domain rotation in two distinct conformations by engineered disulfide bridges. Protein Sci (2004) 0.98
Structural insights into eukaryotic ribosomes and the initiation of translation. Curr Opin Struct Biol (2012) 0.97
Imperfect pseudo-merohedral twinning in crystals of fungal fatty acid synthase. Acta Crystallogr D Biol Crystallogr (2009) 0.95
Differential modes of transfer RNASer recognition in Methanosarcina barkeri. J Biol Chem (2004) 0.94
Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway. Nat Commun (2012) 0.93
Peroxin Pex21p interacts with the C-terminal noncatalytic domain of yeast seryl-tRNA synthetase and forms a specific ternary complex with tRNA(Ser). FEBS J (2007) 0.91
Crystal structure of the yeast ribosomal protein rpS3 in complex with its chaperone Yar1. J Mol Biol (2013) 0.90
Crystal structure of the complex between prokaryotic ubiquitin-like protein and its ligase PafA. J Am Chem Soc (2013) 0.88
An archaeal tRNA-synthetase complex that enhances aminoacylation under extreme conditions. J Biol Chem (2010) 0.86
7.5-Å cryo-em structure of the mycobacterial fatty acid synthase. J Mol Biol (2013) 0.86
Recycling of aborted ribosomal 50S subunit-nascent chain-tRNA complexes by the heat shock protein Hsp15. J Mol Biol (2008) 0.86
Target-directed proteolysis at the ribosome. Proc Natl Acad Sci U S A (2005) 0.85
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile. J Med Chem (2015) 0.85
Idiosyncratic helix-turn-helix motif in Methanosarcina barkeri seryl-tRNA synthetase has a critical architectural role. J Biol Chem (2009) 0.84
Shuffling of discrete tRNASer regions reveals differently utilized identity elements in yeast and methanogenic archaea. J Mol Biol (2006) 0.83
Crystal structure of Thermotoga maritima alpha-glucosidase AglA defines a new clan of NAD+-dependent glycosidases. J Biol Chem (2003) 0.83
The enzyme-binding region of human GM2-activator protein. FEBS J (2006) 0.82
Characterization of variants of the pore-forming toxin ClyA from Escherichia coli controlled by a redox switch. Biochemistry (2014) 0.82
The proximal region of a noncatalytic eukaryotic seryl-tRNA synthetase extension is required for protein stability in vitro and in vivo. Arch Biochem Biophys (2007) 0.82
Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition. FEBS J (2008) 0.81
Identification of amino acids in the N-terminal domain of atypical methanogenic-type Seryl-tRNA synthetase critical for tRNA recognition. J Biol Chem (2009) 0.81
X-ray crystallographic structure determination of large asymmetric macromolecular assemblies. Methods Enzymol (2003) 0.81
Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase. FEMS Microbiol Lett (2002) 0.81
Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. J Biomol NMR (2015) 0.81
Archaeal aminoacyl-tRNA synthetases interact with the ribosome to recycle tRNAs. Nucleic Acids Res (2014) 0.80
Selective inhibition of divergent seryl-tRNA synthetases by serine analogues. FEBS Lett (2005) 0.80
Recognition between tRNASer and archaeal seryl-tRNA synthetases monitored by suppression of bacterial amber mutations. FEMS Microbiol Lett (2008) 0.79
Reprint of "Generation of ribosome nascent chain complexes for structural and functional studies" [J. Struct. Biol. 158 (2007) 463-471]. J Struct Biol (2007) 0.79
Structure and function of large cellular assemblies. Curr Opin Struct Biol (2010) 0.79
tRNA-dependent amino acid discrimination by yeast seryl-tRNA synthetase. Eur J Biochem (2002) 0.79
Conserved sequence motifs and the structure of the mTOR kinase domain. Biochem Soc Trans (2013) 0.78
Dual targeting of organellar seryl-tRNA synthetase to maize mitochondria and chloroplasts. Plant Cell Rep (2008) 0.78
Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.77
Enhanced SnapShot: Pore-forming toxins. Cell (2010) 0.77
An idiosyncratic serine ordering loop in methanogen seryl-tRNA synthetases guides substrates through seryl-tRNASer formation. Biochimie (2011) 0.77