Published in J Cell Sci on August 03, 2010
Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci (2012) 2.89
Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol (2013) 1.14
Engineering a stem cell house into a home. Stem Cell Res Ther (2011) 1.04
Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers. Adv Mater (2013) 1.01
Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface (2013) 0.96
Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model. J Biomed Mater Res A (2013) 0.95
Genetically encoded sender-receiver system in 3D mammalian cell culture. ACS Synth Biol (2013) 0.90
Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns. Lab Chip (2014) 0.88
Fracture-based micro- and nanofabrication for biological applications. Biomater Sci (2014) 0.88
A potential role for differential contractility in early brain development and evolution. Biomech Model Mechanobiol (2012) 0.85
Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective. Biomed Microdevices (2013) 0.84
Aqueous two-phase printing of cell-containing contractile collagen microgels. Biomaterials (2013) 0.84
Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends Cell Biol (2010) 0.83
One-dimensional patterning of cells in silicone wells via compression-induced fracture. J Biomed Mater Res A (2013) 0.82
Microscale 3D collagen cell culture assays in conventional flat-bottom 384-well plates. J Lab Autom (2014) 0.76
Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells. Acta Biomater (2014) 0.75
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep (2015) 0.75
Regulation of Epithelial-to-Mesenchymal Transition Using Biomimetic Fibrous Scaffolds. ACS Appl Mater Interfaces (2016) 0.75
Time-lapse imaging assay using the BioStation CT: a sensitive drug-screening method for three-dimensional cell culture. Cancer Sci (2015) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30
Geometric control of cell life and death. Science (1997) 18.13
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell (2004) 16.89
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol (2005) 13.90
Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81
Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer (2005) 8.70
Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A (1992) 8.69
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Collagen substrata for studies on cell behavior. J Cell Biol (1972) 7.00
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 6.26
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell (1991) 4.98
Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J Cell Biol (1991) 4.91
Networks and crosstalk: integrin signalling spreads. Nat Cell Biol (2002) 4.66
Cell interactions with three-dimensional matrices. Curr Opin Cell Biol (2002) 4.34
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations. Biophys J (1999) 3.26
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J (2002) 3.25
Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol (2005) 3.20
Fibronectin controls capillary endothelial cell growth by modulating cell shape. Proc Natl Acad Sci U S A (1990) 3.18
Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J Cell Biol (2001) 2.95
In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J Cell Biol (1983) 2.91
Potential for control of signaling pathways via cell size and shape. Curr Biol (2006) 2.89
Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J Cell Biol (1998) 2.87
ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell (2004) 2.73
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol Biol Cell (1998) 2.71
Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci (1995) 2.39
Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening. Curr Biol (2009) 2.37
Gene expression perturbation in vitro--a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol (2005) 2.35
Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol (2003) 2.31
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis. Nat Cell Biol (2006) 2.01
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell (2003) 1.82
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res (2007) 1.63
Precision of the Dpp gradient. Development (2008) 1.59
Signal dynamics in Sonic hedgehog tissue patterning. Development (2006) 1.43
The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination. Tissue Eng Part B Rev (2009) 1.37
Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype. Proc Natl Acad Sci U S A (2006) 1.34
Myosin II regulates the shape of three-dimensional intestinal epithelial cysts. J Cell Sci (2008) 1.16
Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J Cell Biol (2000) 1.14
Collagens in the liver extracellular matrix bind hepatocyte growth factor. Gastroenterology (1998) 1.10
Vascular smooth muscle cell response on thin films of collagen. Matrix Biol (2005) 1.04
Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching. J Control Release (2005) 0.95
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell (2004) 16.89
Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A (2003) 11.53
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25
Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell (2009) 5.43
Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci U S A (2005) 5.22
Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods (2010) 4.74
Mechanotransduction in development: a growing role for contractility. Nat Rev Mol Cell Biol (2009) 4.10
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater (2012) 4.10
Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A (2010) 3.44
Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nat Methods (2010) 3.35
Versatile, fully automated, microfluidic cell culture system. Anal Chem (2007) 3.19
Nanopattern-induced changes in morphology and motility of smooth muscle cells. Biomaterials (2005) 2.94
Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci (2012) 2.89
Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater (2013) 2.84
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Med (2006) 2.78
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells (2008) 2.34
Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. J Biomed Mater Res A (2003) 2.17
Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng (2004) 2.13
Magnetic microposts as an approach to apply forces to living cells. Proc Natl Acad Sci U S A (2007) 2.10
Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells (2010) 2.09
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol (2006) 2.08
Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci (2009) 2.04
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol (2013) 2.02
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell (2004) 1.98
A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Eng Part A (2012) 1.95
Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proc Natl Acad Sci U S A (2009) 1.89
Nanotechnology for cell-substrate interactions. Ann Biomed Eng (2006) 1.87
Cell shape and substrate rigidity both regulate cell stiffness. Biophys J (2011) 1.86
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials (2010) 1.80
Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell (2012) 1.80
Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74
A hitchhiker's guide to mechanobiology. Dev Cell (2011) 1.72
Cell-cell signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Lett (2002) 1.70
Cytoskeleton-based forecasting of stem cell lineage fates. Proc Natl Acad Sci U S A (2009) 1.68
Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A (2012) 1.67
Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res (2007) 1.64
Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors. Mech Chem Biosyst (2005) 1.63
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res (2007) 1.63
E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol (2006) 1.61
Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc (2011) 1.60
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proc Natl Acad Sci U S A (2012) 1.59
Microfabricated silicone elastomeric post arrays for measuring traction forces of adherent cells. Methods Cell Biol (2007) 1.56
Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys (2012) 1.55
Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today (2002) 1.54
Cell traction forces direct fibronectin matrix assembly. Biophys J (2009) 1.54
Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem (2010) 1.53
How vinculin regulates force transmission. Proc Natl Acad Sci U S A (2013) 1.51
Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50
Myofibrillar architecture in engineered cardiac myocytes. Circ Res (2008) 1.48
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Proc Natl Acad Sci U S A (2013) 1.44
Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol (2009) 1.44
Lymphatic function is required prenatally for lung inflation at birth. J Exp Med (2014) 1.44
Non-muscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct. J Biol Chem (2004) 1.42
Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells Dev (2011) 1.40
Fabrication of aligned microstructures with a single elastomeric stamp. Proc Natl Acad Sci U S A (2002) 1.38
Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnol Prog (2005) 1.37
Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A (2009) 1.36
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res (2007) 1.35
Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium. Biophys J (2011) 1.34
Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng Part A (2010) 1.33
Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. Biophys J (2012) 1.31
Endogenous patterns of mechanical stress are required for branching morphogenesis. Integr Biol (Camb) (2010) 1.31
Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions. Biophys J (2012) 1.30
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A (2013) 1.29
Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip (2012) 1.28
Cellular and multicellular form and function. Adv Drug Deliv Rev (2007) 1.24
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (2013) 1.23
VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Sci (2003) 1.23
Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res (2007) 1.22
Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A (2013) 1.19
Facile modification of collagen directed by collagen mimetic peptides. J Am Chem Soc (2005) 1.19
Endothelial cell sensing of flow direction. Arterioscler Thromb Vasc Biol (2013) 1.17
New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int Rev Cell Mol Biol (2012) 1.17
Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci (2008) 1.17
Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc (2011) 1.15
Dielectrophoretic registration of living cells to a microelectrode array. Biosens Bioelectron (2004) 1.14
Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab Chip (2005) 1.13
Dielectrophoretic registration of living cells to a microelectrode array. Biosens Bioelectron (2004) 1.10
Characterization of the nuclear deformation caused by changes in endothelial cell shape. J Biomech Eng (2004) 1.10
Immobilization of growth factors on collagen scaffolds mediated by polyanionic collagen mimetic peptides and its effect on endothelial cell morphogenesis. Biomacromolecules (2008) 1.10
Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. Development (2013) 1.09
Host epithelial geometry regulates breast cancer cell invasiveness. Proc Natl Acad Sci U S A (2012) 1.09