The role of secretory antibodies in infection immunity.

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Published in Nat Rev Microbiol on August 09, 2010

Authors

Richard A Strugnell1, Odilia L C Wijburg

Author Affiliations

1: Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, VIC 3010 Australia. rastru@unimelb.edu.au

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Salmonellosis: host immune responses and bacterial virulence determinants. Annu Rev Immunol (1996) 3.41

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Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination. Mucosal Immunol (2009) 1.72

Adsorption of immunolgobulin A onto oral bacteria in vivo. J Bacteriol (1968) 1.68

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