Published in ACS Chem Biol on October 15, 2010
Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov (2011) 4.16
Antimicrobial peptides: successes, challenges and unanswered questions. J Membr Biol (2011) 1.83
Membrane-active host defense peptides--challenges and perspectives for the development of novel anticancer drugs. Chem Phys Lipids (2011) 1.45
Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol (2011) 1.45
Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity. Proc Natl Acad Sci U S A (2011) 1.37
Spontaneous membrane-translocating peptides by orthogonal high-throughput screening. J Am Chem Soc (2011) 1.35
Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol (2011) 1.34
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions. Structure (2012) 1.10
Localized permeabilization of E. coli membranes by the antimicrobial peptide Cecropin A. Biochemistry (2013) 1.01
A lipocentric view of peptide-induced pores. Eur Biophys J (2011) 0.98
Antibacterial studies of cationic polymers with alternating, random, and uniform backbones. ACS Chem Biol (2011) 0.97
Determining the mechanism of membrane permeabilizing peptides: identification of potent, equilibrium pore-formers. Biochim Biophys Acta (2012) 0.96
Gain-of-function analogues of the pore-forming peptide melittin selected by orthogonal high-throughput screening. J Am Chem Soc (2012) 0.95
A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbations. Biophys J (2013) 0.91
Oligomeric interactions of sarcolipin and the Ca-ATPase. J Biol Chem (2011) 0.90
Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation. PLoS Pathog (2012) 0.90
Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria. Antibiotics (Basel) (2015) 0.90
Mechanism Matters: A Taxonomy of Cell Penetrating Peptides. Trends Biochem Sci (2015) 0.89
Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry (2013) 0.88
The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization. Biochim Biophys Acta (2013) 0.88
Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides. Antimicrob Agents Chemother (2015) 0.87
High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion. J Am Chem Soc (2014) 0.87
Resurrecting inactive antimicrobial peptides from the lipopolysaccharide trap. Antimicrob Agents Chemother (2014) 0.87
A highly charged voltage-sensor helix spontaneously translocates across membranes. Angew Chem Int Ed Engl (2012) 0.87
Role of Amphiphilicity in the Design of Synthetic Mimics of Antimicrobial Peptides with Gram-negative Activity. ACS Med Chem Lett (2013) 0.86
Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits. J Am Chem Soc (2014) 0.85
Peptides and Peptidomimetics for Antimicrobial Drug Design. Pharmaceuticals (Basel) (2015) 0.85
Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications. Front Microbiol (2011) 0.84
Highly efficient macromolecule-sized poration of lipid bilayers by a synthetically evolved peptide. J Am Chem Soc (2014) 0.84
Defining the membrane disruption mechanism of kalata B1 via coarse-grained molecular dynamics simulations. Sci Rep (2014) 0.84
A common landscape for membrane-active peptides. Protein Sci (2013) 0.83
Synthetic molecular evolution of pore-forming peptides by iterative combinatorial library screening. ACS Chem Biol (2013) 0.83
Membrane-proximal external HIV-1 gp41 motif adapted for destabilizing the highly rigid viral envelope. Biophys J (2011) 0.82
Understanding the dark and light-enhanced bactericidal action of cationic conjugated polyelectrolytes and oligomers. Langmuir (2013) 0.82
Membrane binding of an acyl-lactoferricin B antimicrobial peptide from solid-state NMR experiments and molecular dynamics simulations. Biochim Biophys Acta (2011) 0.82
Peptide array based discovery of synthetic antimicrobial peptides. Front Microbiol (2013) 0.82
Statistical analysis of peptide-induced graded and all-or-none fluxes in giant vesicles. Biophys J (2013) 0.82
Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time. Trends Microbiol (2015) 0.81
Expression and characterization of cecropinXJ, a bioactive antimicrobial peptide from Bombyx mori (Bombycidae, Lepidoptera) in Escherichia coli. Exp Ther Med (2013) 0.81
Direct cytosolic delivery of polar cargo to cells by spontaneous membrane-translocating peptides. J Biol Chem (2013) 0.81
Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue. J Am Chem Soc (2013) 0.81
Antimicrobial peptides and wound healing: biological and therapeutic considerations. Exp Dermatol (2016) 0.80
Effect of repetitive lysine-tryptophan motifs on the eukaryotic membrane. Int J Mol Sci (2013) 0.80
Interplay among subunit identity, subunit proportion, chain length, and stereochemistry in the activity profile of sequence-random peptide mixtures. J Am Chem Soc (2013) 0.80
Antifungal Activity of 14-Helical β-Peptides against Planktonic Cells and Biofilms of Candida Species. Pharmaceuticals (Basel) (2015) 0.80
Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity. J Am Chem Soc (2015) 0.80
Simulating the mechanism of antimicrobial lipopeptides with all-atom molecular dynamics. Biochemistry (2013) 0.80
Topical antimicrobials for burn infections - an update. Recent Pat Antiinfect Drug Discov (2013) 0.80
Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target. J Biol Chem (2012) 0.79
pH Dependence of microbe sterilization by cationic antimicrobial peptides. Antimicrob Agents Chemother (2013) 0.79
Computational studies of peptide-induced membrane pore formation. Philos Trans R Soc Lond B Biol Sci (2017) 0.78
In vitro activities of dermaseptins K4S4 and K4K20S4 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa planktonic growth and biofilm formation. Antimicrob Agents Chemother (2014) 0.78
New edge of antibiotic development: antimicrobial peptides and corresponding resistance. Front Microbiol (2014) 0.78
Antimicrobial peptides and their analogs: searching for new potential therapeutics. Perspect Medicin Chem (2014) 0.78
What Goes around Comes around-A Comparative Study of the Influence of Chemical Modifications on the Antimicrobial Properties of Small Cyclic Peptides. Pharmaceuticals (Basel) (2013) 0.78
Interaction of nuclease colicins with membranes: insertion depth correlates with bilayer perturbation. PLoS One (2012) 0.78
NMR structure of temporin-1 ta in lipopolysaccharide micelles: mechanistic insight into inactivation by outer membrane. PLoS One (2013) 0.78
Prediction of linear cationic antimicrobial peptides based on characteristics responsible for their interaction with the membranes. J Chem Inf Model (2014) 0.78
Membrane Thinning and Thickening Induced by Membrane-Active Amphipathic Peptides. Front Cell Dev Biol (2016) 0.78
Antimicrobial Peptides Targeting Gram-Positive Bacteria. Pharmaceuticals (Basel) (2016) 0.77
Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation. J Virol (2016) 0.77
Toward the de novo design of antimicrobial peptides: Lack of correlation between peptide permeabilization of lipid vesicles and antimicrobial, cytolytic, or cytotoxic activity in living cells. Biopolymers (2014) 0.77
Medium effects on minimum inhibitory concentrations of nylon-3 polymers against E. coli. PLoS One (2014) 0.77
A lack of synergy between membrane-permeabilizing cationic antimicrobial peptides and conventional antibiotics. Biochim Biophys Acta (2014) 0.77
Determining the Effects of Membrane-Interacting Peptides on Membrane Integrity. Methods Mol Biol (2015) 0.77
Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents. Soft Matter (2015) 0.77
On the role of NMR spectroscopy for characterization of antimicrobial peptides. Methods Mol Biol (2013) 0.77
Calcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity. Sci Rep (2016) 0.76
Dynamic scenario of membrane binding process of kalata b1. PLoS One (2014) 0.76
Combined Bioinformatic and Rational Design Approach To Develop Antimicrobial Peptides against Mycobacterium tuberculosis. Antimicrob Agents Chemother (2016) 0.76
Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif. J Am Chem Soc (2015) 0.76
Adsorption of cationic peptides to solid surfaces of glass and plastic. PLoS One (2015) 0.76
RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities. J Am Chem Soc (2012) 0.76
An index for characterization of natural and non-natural amino acids for peptidomimetics. PLoS One (2013) 0.75
Simulations of Membrane-Disrupting Peptides I: Alamethicin Pore Stability and Spontaneous Insertion. Biophys J (2016) 0.75
Selective Membrane Disruption Mechanism of an Antibacterial γ-AApeptide Defined by EPR Spectroscopy. Biophys J (2016) 0.75
Testing the limits of rational design by engineering pH sensitivity into membrane-active peptides. Biochim Biophys Acta (2015) 0.75
Assessment of RNA carrier function in peptide amphiphiles derived from the HIV fusion peptide. Peptides (2016) 0.75
Cloning and Expression of β-Defensin from Soiny Mullet (Liza haematocheila), with Insights of its Antibacterial Mechanism. PLoS One (2016) 0.75
Non-disulfide-Bridge Peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits the Growth of Mycobacterium abscessus subsp. massiliense. Front Microbiol (2017) 0.75
Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria. Int J Mol Sci (2016) 0.75
Cytotoxicity of a new antimicrobial coating for surgical screws: an in vivo study. Singapore Med J (2016) 0.75
Bacillus thuringiensis Cyt2Aa2 toxin disrupts cell membranes by forming large protein aggregates. Biosci Rep (2016) 0.75
Cell-penetrating recombinant peptides for potential use in agricultural pest control applications. Pharmaceuticals (Basel) (2012) 0.75
Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design. Front Neurosci (2017) 0.75
New Peptide-based antimicrobials for tackling drug resistance in bacteria: single-cell fluorescence imaging. ACS Med Chem Lett (2013) 0.75
Editorial: Antimicrobial Peptides - Interaction with Membrane Lipids and Proteins. Front Cell Dev Biol (2017) 0.75
Diffusion as a probe of peptide-induced membrane domain formation. Biochemistry (2011) 0.75
Mechanism of Four de Novo Designed Antimicrobial Peptides. J Biol Chem (2016) 0.75
Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction. Biophys J (2016) 0.75
Simulations of Membrane-Disrupting Peptides II: AMP Piscidin 1 Favors Surface Defects over Pores. Biophys J (2016) 0.75
Antimicrobial peptides are degraded by the cytosolic proteases of human erythrocytes. Biochim Biophys Acta (2017) 0.75
Antibacterial and Antibiofilm Activities of a Novel Synthetic Cyclic Lipopeptide Against Cariogenic Streptococcus mutans UA159. Antimicrob Agents Chemother (2017) 0.75
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses. Nat Commun (2017) 0.75
Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflata. Mar Drugs (2017) 0.75
Controlling the Biomimetic Implant Interface: Modulating Antimicrobial Activity by Spacer Design. J Mol Eng Mater (2016) 0.75
Ebola Virus Delta Peptide is a Viroporin. J Virol (2017) 0.75
Polydim-I antimicrobial activity against MDR bacteria and its model membrane interaction. PLoS One (2017) 0.75
Effect of the aspartic acid D2 on the affinity of Polybia-MP1 to anionic lipid vesicles. Eur Biophys J (2014) 0.75
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc (2008) 7.92
Vesicles of variable sizes produced by a rapid extrusion procedure. Biochim Biophys Acta (1986) 7.07
Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure. Biophys J (1992) 6.46
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature (1981) 5.66
The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat Rev Microbiol (2006) 4.29
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90
APD: the Antimicrobial Peptide Database. Nucleic Acids Res (2004) 3.60
Ionic channels in nerve membranes. Prog Biophys Mol Biol (1970) 3.14
Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol (2009) 2.99
Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci (1994) 2.43
Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys J (2000) 2.41
Ultrashort antibacterial and antifungal lipopeptides. Proc Natl Acad Sci U S A (2006) 2.15
Mimicry of antimicrobial host-defense peptides by random copolymers. J Am Chem Soc (2007) 2.12
High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol (2005) 2.01
Bacterial membrane lipids: where do we stand? Annu Rev Microbiol (2003) 1.93
Detergent-like actions of linear amphipathic cationic antimicrobial peptides. Biochim Biophys Acta (2006) 1.93
Mechanism of alamethicin insertion into lipid bilayers. Biophys J (1996) 1.92
Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR. Proc Natl Acad Sci U S A (2006) 1.87
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry (1990) 1.86
Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol (2006) 1.84
Toroidal pores formed by antimicrobial peptides show significant disorder. Biochim Biophys Acta (2008) 1.73
Mechanisms of antimicrobial, cytolytic, and cell-penetrating peptides: from kinetics to thermodynamics. Biochemistry (2009) 1.72
Control of cell selectivity of antimicrobial peptides. Biochim Biophys Acta (2008) 1.66
A quantitative model for the all-or-none permeabilization of phospholipid vesicles by the antimicrobial peptide cecropin A. Biophys J (2007) 1.64
Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect Immun (1981) 1.61
Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria. Biochim Biophys Acta (1997) 1.59
AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics (2007) 1.59
Lipid domains in bacterial membranes and the action of antimicrobial agents. Biochim Biophys Acta (2008) 1.58
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J Am Chem Soc (2009) 1.53
Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity. Biochemistry (2002) 1.49
Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes. J Am Chem Soc (2008) 1.46
Membrane orientation of the N-terminal segment of alamethicin determined by solid-state 15N NMR. Biophys J (1995) 1.45
Kinetics of dye efflux and lipid flip-flop induced by delta-lysin in phosphatidylcholine vesicles and the mechanism of graded release by amphipathic, alpha-helical peptides. Biochemistry (2004) 1.45
Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes? Peptides (2003) 1.42
Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. J Mol Biol (1996) 1.42
Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem (2001) 1.41
Magainin 2 revisited: a test of the quantitative model for the all-or-none permeabilization of phospholipid vesicles. Biophys J (2009) 1.40
Single giant unilamellar vesicle method reveals effect of antimicrobial peptide magainin 2 on membrane permeability. Biochemistry (2005) 1.32
Purification and characterization of an antibacterial protein from haemolymph of Sarcophaga peregrina (flesh-fly) larvae. Biochem J (1983) 1.32
A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids. J Biol Chem (2001) 1.30
Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci U S A (2005) 1.28
Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins. J Biol Chem (1997) 1.26
Probing the "charge cluster mechanism" in amphipathic helical cationic antimicrobial peptides. Biochemistry (2010) 1.24
Determining the membrane topology of peptides by fluorescence quenching. Biochemistry (2000) 1.24
Structure of the alamethicin pore reconstructed by x-ray diffraction analysis. Biophys J (2008) 1.24
Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob Agents Chemother (2003) 1.20
CD spectra of indolicidin antimicrobial peptides suggest turns, not polyproline helix. Biochemistry (1999) 1.19
Solid-state NMR investigation of the selective disruption of lipid membranes by protegrin-1. Biochemistry (2004) 1.18
Length effects in antimicrobial peptides of the (RW)n series. Antimicrob Agents Chemother (2006) 1.16
Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers. Biophys J (2009) 1.14
Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry (2007) 1.12
High-throughput discovery of broad-spectrum peptide antibiotics. FASEB J (2010) 1.11
Interactions of an antimicrobial peptide, magainin 2, with lipopolysaccharide-containing liposomes as a model for outer membranes of gram-negative bacteria. FEBS Lett (1999) 1.10
The interactions of antimicrobial peptides derived from lysozyme with model membrane systems. Biochim Biophys Acta (2005) 1.10
Magainin 2-induced pore formation in the lipid membranes depends on its concentration in the membrane interface. J Phys Chem B (2009) 1.01
Synthesis and characterization of indolicidin, a tryptophan-rich antimicrobial peptide from bovine neutrophils. Int J Pept Protein Res (1995) 1.00
The activity of the amphipathic peptide delta-lysin correlates with phospholipid acyl chain structure and bilayer elastic properties. Biophys J (2008) 1.00
Antimicrobial activities and structures of two linear cationic peptide families with various amphipathic beta-sheet and alpha-helical potentials. Antimicrob Agents Chemother (2005) 0.92
Revealing the lytic mechanism of the antimicrobial peptide gomesin by observing giant unilamellar vesicles. Langmuir (2010) 0.88
The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother (2008) 0.86
A peptide fragment derived from the T-cell antigen receptor protein alpha-chain adopts beta-sheet structure and shows potent antimicrobial activity. Peptides (2008) 0.80
Toward genomic identification of beta-barrel membrane proteins: composition and architecture of known structures. Protein Sci (2002) 2.25
Energetics of peptide and protein binding to lipid membranes. Adv Exp Med Biol (2010) 0.79