Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design.

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Published in Front Neurosci on February 14, 2017

Authors

Jianguo Li1, Jun-Jie Koh2, Shouping Liu2, Rajamani Lakshminarayanan2, Chandra S Verma3, Roger W Beuerman4

Author Affiliations

1: Ocular Chemistry and Anti-Infectives, Singapore Eye Research InstituteSingapore, Singapore; Agency for Science, Technology and Research (ASTAR), Bioinformatics InstituteSingapore, Singapore; Duke-NUS Graduate Medical School, SRP Neuroscience and BDSingapore, Singapore.
2: Ocular Chemistry and Anti-Infectives, Singapore Eye Research Institute Singapore, Singapore.
3: Ocular Chemistry and Anti-Infectives, Singapore Eye Research InstituteSingapore, Singapore; Agency for Science, Technology and Research (ASTAR), Bioinformatics InstituteSingapore, Singapore; Department of Biological Sciences, National University of SingaporeSingapore, Singapore; School of Biological Sciences, Nanyang Technological UniversitySingapore, Singapore.
4: Ocular Chemistry and Anti-Infectives, Singapore Eye Research InstituteSingapore, Singapore; Duke-NUS Graduate Medical School, SRP Neuroscience and BDSingapore, Singapore.

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Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53

The gramicidin A transmembrane channel: a proposed pi(L,D) helix. Proc Natl Acad Sci U S A (1971) 7.74

Peptidoglycan structure and architecture. FEMS Microbiol Rev (2008) 6.69

Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev (2003) 6.57

High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR. Science (1993) 5.33

Mode of action of membrane active antimicrobial peptides. Biopolymers (2002) 4.74

Diversity of antimicrobial peptides and their mechanisms of action. Biochim Biophys Acta (1999) 4.71

Barrel-stave model or toroidal model? A case study on melittin pores. Biophys J (2001) 3.80

Statistical analysis of alamethicin channels in black lipid membranes. J Membr Biol (1974) 3.63

Toxicity of polymyxins: a systematic review of the evidence from old and recent studies. Crit Care (2006) 3.35

Advances in understanding bacterial outer-membrane biogenesis. Nat Rev Microbiol (2006) 3.23

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol (2011) 3.21

Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr Opin Pharmacol (2006) 2.95

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol (2014) 2.87

Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc Natl Acad Sci U S A (2006) 2.81

Imp/OstA is required for cell envelope biogenesis in Escherichia coli. Mol Microbiol (2002) 2.72

Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta (1998) 2.71

Mode of action of the antimicrobial peptide indolicidin. J Biol Chem (1996) 2.57

The structure of melittin in the form I crystals and its implication for melittin's lytic and surface activities. Biophys J (1982) 2.50

Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry (2003) 2.48

In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett (2005) 2.48

A new type of signal peptide: central role of a twin-arginine motif in transfer signals for the delta pH-dependent thylakoidal protein translocase. EMBO J (1995) 2.29

Describing the mechanism of antimicrobial peptide action with the interfacial activity model. ACS Chem Biol (2010) 2.27

Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature (2005) 2.23

Development of daptomycin for gram-positive infections. J Antimicrob Chemother (2000) 2.21

Antibiotic resistance: the last resort. Nature (2013) 2.20

Arginine-rich cell-penetrating peptides. FEBS Lett (2009) 2.17

The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov (2015) 2.15

Ultrashort antibacterial and antifungal lipopeptides. Proc Natl Acad Sci U S A (2006) 2.15

Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action. Biochim Biophys Acta (2006) 2.14

Antimicrobial peptides in action. J Am Chem Soc (2006) 2.09

Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J Biol Chem (1997) 2.05

CAMP: a useful resource for research on antimicrobial peptides. Nucleic Acids Res (2009) 2.02

Pore formation and translocation of melittin. Biophys J (1997) 1.98

A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res (2005) 1.97

De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A (2002) 1.95

Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun (2008) 1.91

Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. J Biol Chem (1988) 1.91

The need for new antibiotics. Clin Microbiol Infect (2004) 1.87

Peptide therapeutics: current status and future directions. Drug Discov Today (2014) 1.83

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations. Nat Rev Microbiol (2009) 1.79

A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol (2012) 1.79

Toroidal pores formed by antimicrobial peptides show significant disorder. Biochim Biophys Acta (2008) 1.73

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol (2013) 1.73

Solid-state NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from magainin 2 and melittin. Biophys J (2006) 1.70

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Biochim Biophys Acta (1999) 1.65

Peptide-membrane interactions and mechanisms of membrane destruction by amphipathic alpha-helical antimicrobial peptides. Biochim Biophys Acta (2006) 1.62

Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett (2013) 1.60

AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics (2007) 1.59

The roles of antimicrobial peptides in innate host defense. Curr Pharm Des (2009) 1.58

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions. Nat Rev Microbiol (2015) 1.56

From antimicrobial to anticancer peptides. A review. Front Microbiol (2013) 1.56

De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications. Acc Chem Res (2010) 1.52

Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48

A brief history of synthetic biology. Nat Rev Microbiol (2014) 1.47

Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance. Front Microbiol (2013) 1.42

Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. J Mol Biol (1996) 1.42

Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One (2011) 1.39

Structure and orientation of pardaxin determined by NMR experiments in model membranes. J Biol Chem (2004) 1.38

Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studies. Biochim Biophys Acta (2006) 1.37

Membrane channel formation by antimicrobial protegrins. Biochim Biophys Acta (1999) 1.36

The pharmacophore of short cationic antibacterial peptides. J Med Chem (2003) 1.35

Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application. Peptides (2012) 1.34

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem Biol (2009) 1.33

Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide. Biochem Pharmacol (1999) 1.31

A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids. J Biol Chem (2001) 1.30

Crucial role of the membrane potential for ATP synthesis by F(1)F(o) ATP synthases. J Exp Biol (2000) 1.30

Synthetic antimicrobial oligomers induce a composition-dependent topological transition in membranes. J Am Chem Soc (2007) 1.29

Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci U S A (2005) 1.28

Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl (2004) 1.26

The role of antimicrobial peptides in innate immunity. Integr Comp Biol (2003) 1.25

APD3: the antimicrobial peptide database as a tool for research and education. Nucleic Acids Res (2015) 1.22

Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes. J Biol Chem (2002) 1.20

Does arginine remain protonated in the lipid membrane? Insights from microscopic pKa calculations. Biophys J (2008) 1.18

Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics (2007) 1.16

Length effects in antimicrobial peptides of the (RW)n series. Antimicrob Agents Chemother (2006) 1.16

Coarse-grained simulations of lipid bilayers. J Chem Phys (2004) 1.16

Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother (1994) 1.14

Conformation and membrane orientation of amphiphilic helical peptides by oriented circular dichroism. Biophys J (2008) 1.14

Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry (2007) 1.12

Cholesterol reduces pardaxin's dynamics-a barrel-stave mechanism of membrane disruption investigated by solid-state NMR. Biochim Biophys Acta (2009) 1.12

Peptide-lipid huge toroidal pore, a new antimicrobial mechanism mediated by a lactococcal bacteriocin, lacticin Q. Antimicrob Agents Chemother (2009) 1.10

Process of inducing pores in membranes by melittin. Proc Natl Acad Sci U S A (2013) 1.09

Membrane-active peptides and the clustering of anionic lipids. Biophys J (2012) 1.07

The role of Paneth cells and their antimicrobial peptides in innate host defense. Trends Microbiol (2004) 1.06

In silico toxicology for the pharmaceutical sciences. Toxicol Appl Pharmacol (2009) 1.06

Recent synthetic transport systems. Chem Soc Rev (2011) 1.06

Multiple indications for anti-inflammatory apolipoprotein mimetic peptides. Curr Opin Investig Drugs (2008) 1.06

Ab initio design of potent anti-MRSA peptides based on database filtering technology. J Am Chem Soc (2012) 1.06

Antimicrobial activity of short arginine- and tryptophan-rich peptides. J Pept Sci (2002) 1.05

Characterization of the polymyxin B resistome of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2012) 1.05

Antibiotics in the clinical pipeline at the end of 2015. J Antibiot (Tokyo) (2016) 1.04

Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens. Antimicrob Agents Chemother (2013) 1.03

Curvature elasticity of pure and mixed surfactant films. Phys Rev Lett (1988) 1.03

Antimicrobial peptides and their potential application in inflammation and sepsis. Crit Care (2012) 1.02

The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism. Phys Chem Chem Phys (2012) 0.99