Published in Genome Med on August 10, 2010
Revealing the molecular signatures of host-pathogen interactions. Genome Biol (2011) 0.77
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A whole-genome association study of major determinants for host control of HIV-1. Science (2007) 15.19
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science (2000) 10.40
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med (1996) 7.66
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet (2005) 5.35
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet (2007) 4.23
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet (2009) 3.59
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature (2009) 2.81
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet (2010) 2.73
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. N Engl J Med (2010) 2.47
Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. Proc Natl Acad Sci U S A (2000) 2.44
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet (2010) 2.32
The adaptor molecule CARD9 is essential for tuberculosis control. J Exp Med (2010) 1.70
The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1. Hum Mol Genet (1993) 1.57
More than just SCID--the phenotypic range of combined immunodeficiencies associated with mutations in the recombinase activating genes (RAG) 1 and 2. Clin Immunol (2010) 1.52
Mapping of the X-linked agammaglobulinemia locus by use of restriction fragment-length polymorphism. J Clin Invest (1986) 1.49
Long-term immunological follow-up of children with haemophilus influenzae serotype b vaccine failure in the United Kingdom. Clin Infect Dis (2009) 1.42
Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathog (2010) 1.41
A common genetic fingerprint in leprosy and Crohn's disease? N Engl J Med (2009) 1.39
Complement deficiency and disease: an update. Mol Immunol (2006) 1.33
X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis. Am J Hum Genet (1989) 1.26
Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43. Am J Hum Genet (1996) 1.12
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. Nat Genet (2008) 1.10
New genetic associations detected in a host response study to hepatitis B vaccine. Genes Immun (2010) 1.10
TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol (2008) 1.07
Complement and properidin deficiencies in meningococcal disease. Pediatr Infect Dis J (2006) 1.04
Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy. J Infect Dis (2009) 1.02
Mapping of a gene for X-linked agammaglobulinemia and evidence for genetic heterogeneity. Hum Genet (1986) 0.98
Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children. Clin Infect Dis (2010) 0.89
Genome-wide association studies are coming for human infectious diseases. Genome Med (2009) 0.88
Factor H-binding protein, a unique meningococcal vaccine antigen. Vaccine (2008) 0.86
Refinement of linkage of human severe combined immunodeficiency (SCIDX1) to polymorphic markers in Xq13. Am J Hum Genet (1993) 0.86
Efficacy of gene therapy for SCID is being confirmed. Lancet (2004) 0.83
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A (2011) 6.16
RNA viral community in human feces: prevalence of plant pathogenic viruses. PLoS Biol (2006) 4.93
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet (2010) 4.65
The epidemiology of respiratory syncytial virus lower respiratory tract infections in children less than 5 years of age in Indonesia. Pediatr Infect Dis J (2011) 2.82
Genomic epidemiology of a dengue virus epidemic in urban Singapore. J Virol (2009) 2.74
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet (2009) 2.45
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet (2010) 2.32
Early Dengue infection and outcome study (EDEN) - study design and preliminary findings. Ann Acad Med Singapore (2006) 2.12
Diagnosis of childhood tuberculosis and host RNA expression in Africa. N Engl J Med (2014) 2.12
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nat Genet (2011) 2.00
Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness. PLoS Negl Trop Dis (2008) 1.99
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Med (2013) 1.91
Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis (2007) 1.86
Oseltamivir ring prophylaxis for containment of 2009 H1N1 influenza outbreaks. N Engl J Med (2010) 1.79
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78
Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein. J Virol (2008) 1.65
Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet (2008) 1.65
Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med (2003) 1.61
Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis. PLoS One (2012) 1.58
Collagen-related genes influence the glaucoma risk factor, central corneal thickness. Hum Mol Genet (2010) 1.52
The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis (2011) 1.52
A method for full genome sequencing of all four serotypes of the dengue virus. J Virol Methods (2010) 1.48
The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults. J Virol (2010) 1.47
Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Circ Cardiovasc Genet (2010) 1.45
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis (2012) 1.37
Whole-genome reconstruction and mutational signatures in gastric cancer. Genome Biol (2012) 1.33
Whole genome characterization of non-tissue culture adapted HRSV strains in severely infected children. Virol J (2011) 1.29
Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study. PLoS Negl Trop Dis (2012) 1.29
Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic. Infect Genet Evol (2007) 1.23
Factor H, a regulator of complement activity, is a major determinant of meningococcal disease susceptibility in UK Caucasian patients. Scand J Infect Dis (2006) 1.20
Optimization and clinical validation of a pathogen detection microarray. Genome Biol (2007) 1.18
A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians. BMC Med Genet (2012) 1.12
SARS transmission pattern in Singapore reassessed by viral sequence variation analysis. PLoS Med (2005) 1.11
Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. J Gen Virol (2008) 1.10
Genetic variants of MICB and PLCE1 and associations with non-severe dengue. PLoS One (2013) 1.10
Detection of severe acute respiratory syndrome coronavirus in blood of infected patients. J Clin Microbiol (2004) 1.04
DengueInfo: A web portal to dengue information resources. Infect Genet Evol (2007) 1.03
Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection. PLoS One (2011) 1.01
Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. Proc Natl Acad Sci U S A (2014) 1.00
Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. PLoS One (2013) 0.99
Characterization of early host responses in adults with dengue disease. BMC Infect Dis (2011) 0.99
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease. J Hum Genet (2010) 0.96
Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. J Virol (2013) 0.96
Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations. Hum Mol Genet (2011) 0.96
Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G. PLoS One (2013) 0.94
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection. BMC Infect Dis (2004) 0.93
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease. J Med Genet (2011) 0.92
Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children. Clin Infect Dis (2010) 0.89
Host-pathogen interactions revealed by human genome-wide surveys. Trends Genet (2012) 0.89
Genome-wide association studies are coming for human infectious diseases. Genome Med (2009) 0.88
Deciphering the growth behaviour of Mycobacterium africanum. PLoS Negl Trop Dis (2013) 0.86
Pathogen chip for respiratory tract infections. J Clin Microbiol (2013) 0.85
Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays. Nucleic Acids Res (2010) 0.85
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. PLoS One (2011) 0.84
Population structure of the dengue viruses, Aragua, Venezuela, 2006-2007. Insights into dengue evolution under hyperendemic transmission. Infect Genet Evol (2011) 0.84
Direct whole-genome deep-sequencing of human respiratory syncytial virus A and B from Vietnamese children identifies distinct patterns of inter- and intra-host evolution. J Gen Virol (2015) 0.82
BAsE-Seq: a method for obtaining long viral haplotypes from short sequence reads. Genome Biol (2014) 0.82
Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins. Arthritis Rheum (2012) 0.81
Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria. PLoS One (2013) 0.80
Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks. J Clin Virol (2010) 0.79
Revealing the molecular signatures of host-pathogen interactions. Genome Biol (2011) 0.77
Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children. Vaccine (2010) 0.76
Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun (2015) 0.75
Genetics and Genomics of Infectious Diseases: advancing our understanding of host/pathogens and their interactions. Genome Med (2009) 0.75