Published in J Virol on August 11, 2010
Organization of the influenza virus replication machinery. Science (2012) 1.89
The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol (2011) 1.74
The polymerase of negative-stranded RNA viruses. Curr Opin Virol (2013) 1.10
Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome. PLoS One (2011) 1.10
The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes. Nat Commun (2013) 1.05
Host restriction of influenza virus polymerase activity by PB2 627E is diminished on short viral templates in a nucleoprotein-independent manner. J Virol (2013) 0.95
Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication. J Virol (2014) 0.92
Architecture and regulation of negative-strand viral enzymatic machinery. RNA Biol (2012) 0.90
The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. PLoS Pathog (2011) 0.90
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J Virol (2011) 0.89
Influenza virus activation of the interferon system. Virus Res (2015) 0.88
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nat Rev Microbiol (2016) 0.88
Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export. J Virol (2014) 0.83
DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol (2014) 0.79
Competition between influenza A virus genome segments. PLoS One (2012) 0.79
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II. J Virol (2016) 0.79
The RNA-dependent RNA polymerase of the influenza A virus. Future Virol (2014) 0.76
Ubiquitination up-regulates influenza virus polymerase function. J Virol (2016) 0.76
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles. Sci Rep (2016) 0.75
Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza. Front Microbiol (2017) 0.75
Evolution and ecology of influenza A viruses. Microbiol Rev (1992) 39.99
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A (1999) 14.90
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cell Biol (1987) 11.36
Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell (1981) 8.09
Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38
Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nat Methods (2006) 5.73
Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol (2005) 5.28
Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proc Natl Acad Sci U S A (1981) 5.10
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature (2009) 5.06
XMIPP: a new generation of an open-source image processing package for electron microscopy. J Struct Biol (2004) 4.95
Image processing for electron microscopy single-particle analysis using XMIPP. Nat Protoc (2008) 4.90
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature (2009) 4.49
Polyadenylation sites for influenza virus mRNA. J Virol (1981) 4.42
Determination of influenza virus proteins required for genome replication. J Virol (1990) 4.36
The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol (2008) 4.33
The influenza virus panhandle is involved in the initiation of transcription. J Virol (1994) 3.56
Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer. J Virol (1988) 3.49
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J Virol (2002) 3.37
RNA polymerase of influenza virus: role of NP in RNA chain elongation. J Biochem (1988) 3.23
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol (2007) 3.13
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature (2008) 3.06
Maximum-likelihood multi-reference refinement for electron microscopy images. J Mol Biol (2005) 3.00
Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1. J Virol (1994) 2.98
The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature (2008) 2.74
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog (2008) 2.60
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. J Virol (2004) 2.49
Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. EMBO J (1997) 2.46
Identification of the cap binding protein of influenza virus. Nucleic Acids Res (1982) 2.44
Xmipp: An Image Processing Package for Electron Microscopy J Struct Biol (1996) 2.38
Characterization of influenza virus RNA complete transcripts. Virology (1982) 2.31
The structure of a biologically active influenza virus ribonucleoprotein complex. PLoS Pathog (2009) 2.23
Differential activation of the influenza virus polymerase via template RNA binding. J Virol (1995) 2.18
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding. J Biol Chem (2003) 2.15
Orthomyxovirus replication, transcription, and polyadenylation. Curr Top Microbiol Immunol (2004) 2.04
Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template. J Virol (1999) 2.01
Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase. Nucleic Acids Res (2002) 1.98
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome. Gene (1980) 1.95
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes. Virology (1989) 1.92
3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci U S A (2003) 1.88
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system. J Gen Virol (1994) 1.83
Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J Gen Virol (1997) 1.79
Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. EMBO J (2009) 1.78
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol (1997) 1.71
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue. J Biol Chem (2009) 1.70
The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter. J Virol (2002) 1.66
Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoprotein. J Virol (1999) 1.65
Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics (2008) 1.64
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res (2007) 1.62
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle. EMBO Rep (2001) 1.55
Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. EMBO J (2003) 1.55
Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication. J Virol (2006) 1.53
Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog (2009) 1.51
Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J Virol (2008) 1.47
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replication. J Virol (1999) 1.47
A novel neural network technique for analysis and classification of EM single-particle images. J Struct Biol (2001) 1.37
The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication. PLoS One (2008) 1.37
Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA. Nucleic Acids Res (2003) 1.36
Detection and characterization of influenza A virus PA-PB2 interaction through a bimolecular fluorescence complementation assay. J Virol (2009) 1.30
Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription. J Virol (2003) 1.27
Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy. J Virol (2009) 1.23
Oligomerization of the influenza virus polymerase complex in vivo. J Gen Virol (2008) 1.20
Discontinuous native protein gel electrophoresis. Electrophoresis (2006) 1.18
Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides. Virus Res (1995) 1.08
Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells. Biochem Biophys Res Commun (2009) 0.89
The multifunctional NS1 protein of influenza A viruses. J Gen Virol (2008) 6.87
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol Cell (2006) 2.43
The structure of a biologically active influenza virus ribonucleoprotein complex. PLoS Pathog (2009) 2.23
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. J Clin Invest (2010) 2.18
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
The structure of native influenza virion ribonucleoproteins. Science (2012) 1.93
3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci U S A (2003) 1.88
Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. J Virol (2004) 1.88
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature (2008) 1.66
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. J Gen Virol (2003) 1.65
Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics (2008) 1.64
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res (2007) 1.62
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure (2005) 1.62
3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases. EMBO J (2009) 1.56
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation. J Clin Invest (2013) 1.52
Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog (2009) 1.51
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. EMBO Rep (2006) 1.50
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Dev Cell (2011) 1.50
Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses. J Virol (2003) 1.50
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res (2004) 1.42
Energetics and geometry of FtsZ polymers: nucleated self-assembly of single protofilaments. Biophys J (2007) 1.40
3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase. Proc Natl Acad Sci U S A (2009) 1.38
The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication. PLoS One (2008) 1.37
Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs. EMBO J (2003) 1.32
The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation. J Biol Chem (2010) 1.28
Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription. J Virol (2003) 1.27
Structure of TOR and its complex with KOG1. Mol Cell (2007) 1.23
Oligomerization of the influenza virus polymerase complex in vivo. J Gen Virol (2008) 1.20
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep (2012) 1.16
Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains. EMBO J (2009) 1.12
Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins. J Gen Virol (2005) 1.11
Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy. Proc Natl Acad Sci U S A (2011) 1.09
Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes. Structure (2008) 1.09
Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem (2006) 1.08
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev (2011) 1.05
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nat Struct Mol Biol (2012) 1.04
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Res (2011) 1.04
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin. Proc Natl Acad Sci U S A (2013) 1.01
3D structure of Syk kinase determined by single-particle electron microscopy. Biochim Biophys Acta (2007) 1.01
Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles. J Virol (2005) 1.01
Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA. Nucleic Acids Res (2007) 1.01
Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway. Biochim Biophys Acta (2010) 1.00
Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1-RuvBL2 complex. Nucleic Acids Res (2012) 0.99
Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase. J Immunol (2009) 0.99
Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. DNA Repair (Amst) (2009) 0.98
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res (2010) 0.93
The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. PLoS Pathog (2011) 0.90
Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep (2003) 0.90
Biochemical characterization of the transcriptional regulator BzdR from Azoarcus sp. CIB. J Biol Chem (2010) 0.89
Structural analysis of tobacco etch potyvirus HC-pro oligomers involved in aphid transmission. J Virol (2005) 0.89
Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. J Immunol (2004) 0.89
Kidney histopathological findings in fatal pandemic 2009 influenza A (H1N1). Intensive Care Med (2011) 0.88
Human Staufen1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus multiplication. J Virol (2010) 0.88
Addition of electrophilic lipids to actin alters filament structure. Biochem Biophys Res Commun (2006) 0.86
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. J Virol (2014) 0.86
Functional signature for the recognition of specific target mRNAs by human Staufen1 protein. Nucleic Acids Res (2014) 0.85
Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1. J Cell Sci (2012) 0.85
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res (2011) 0.85
Conformational rearrangements upon Syk auto-phosphorylation. Biochim Biophys Acta (2009) 0.84
Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1. Mol Pharmacol (2010) 0.83
A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors. J Immunol (2014) 0.83
The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins. Sci Signal (2014) 0.81
Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCR alpha gene enhancer. J Immunol (2009) 0.81
Characterization of an enhanced antigenic change in the pandemic 2009 H1N1 influenza virus haemagglutinin. J Gen Virol (2014) 0.80
Molecular architecture and structural transitions of a Clostridium thermocellum mini-cellulosome. J Mol Biol (2011) 0.80
Reconstitution of the Escherichia coli cell division ZipA-FtsZ complexes in nanodiscs as revealed by electron microscopy. J Struct Biol (2012) 0.80
A physicochemical characterization of the interaction between DC-Chol/DOPE cationic liposomes and DNA. J Phys Chem B (2008) 0.79
Influenza virus transcription and replication. Adv Virus Res (2013) 0.79
Structure of human complement C8, a precursor to membrane attack. J Mol Biol (2010) 0.77
Compaction process of calf thymus DNA by mixed cationic-zwitterionic liposomes: a physicochemical study. J Phys Chem B (2008) 0.77
Unraveling the replication machine from negative-stranded RNA viruses. Structure (2003) 0.75
Cationic prevesicle and vesicle nanoaggregates: an experimental and theoretical study. J Phys Chem B (2006) 0.75
A theoretical and experimental approach to the compaction process of DNA by dioctadecyldimethylammonium bromide/zwitterionic mixed liposomes. J Phys Chem B (2009) 0.75
Electrochemical, microscopic, and spectroscopic characterization of prevesicle nanostructures and vesicles on mixed cationic surfactant systems. Langmuir (2006) 0.75
Aggregation phenomena on the ternary ionic-nonionic surfactant system: didodecyldimethylammonium bromide/octyl-beta-D-glucopyranoside/water. Mixed microaggregates, vesicles, and micelles. Langmuir (2005) 0.75