Published in EMBO Rep on April 01, 2001
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs. J Virol (2002) 3.37
The structure of a biologically active influenza virus ribonucleoprotein complex. PLoS Pathog (2009) 2.23
Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus. J Virol (2008) 2.10
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J (2008) 2.10
Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase. Nucleic Acids Res (2002) 1.98
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J Virol (2001) 1.98
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2). EMBO J (2003) 1.95
3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci U S A (2003) 1.88
The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biol (2011) 1.74
Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus. Nat Commun (2012) 1.64
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res (2007) 1.62
Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog (2009) 1.51
The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication. PLoS One (2008) 1.37
Bunyamwera bunyavirus RNA synthesis requires cooperation of 3'- and 5'-terminal sequences. J Virol (2004) 1.30
Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J Virol (2010) 1.21
Work, family socioeconomic status, and growth among working boys in Jordan. Arch Dis Child (2001) 1.19
Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space. J Virol (2004) 1.18
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Res (2013) 1.09
Structural basis for RNA binding and homo-oligomer formation by influenza B virus nucleoprotein. J Virol (2012) 1.05
E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors. Proc Natl Acad Sci U S A (2011) 1.04
Structural and functional characterization of an influenza virus RNA polymerase-genomic RNA complex. J Virol (2010) 1.03
Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein. MBio (2012) 1.01
Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA. Nucleic Acids Res (2007) 1.01
Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627. PLoS One (2012) 0.98
New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions. Antiviral Res (2013) 0.92
Architecture and regulation of negative-strand viral enzymatic machinery. RNA Biol (2012) 0.90
The crystal structure and RNA-binding of an orthomyxovirus nucleoprotein. PLoS Pathog (2013) 0.90
Direct optical detection of viral nucleoprotein binding to an anti-influenza aptamer. Anal Chem (2012) 0.87
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes. Mol Cell Biol (1987) 6.13
Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proc Natl Acad Sci U S A (1981) 5.10
Polyadenylation sites for influenza virus mRNA. J Virol (1981) 4.42
Structure of the ribonucleoprotein of influenza virus. J Virol (1972) 3.11
Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1. J Virol (1994) 2.98
Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent. EMBO J (1994) 2.93
Influenza virus nucleoprotein interacts with influenza virus polymerase proteins. J Virol (1998) 2.54
Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. EMBO J (1997) 2.46
Xmipp: An Image Processing Package for Electron Microscopy J Struct Biol (1996) 2.38
Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. J Virol (1995) 2.02
Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template. J Virol (1999) 2.01
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes. Virology (1989) 1.92
Reconstitution of influenza virus RNA-nucleoprotein complexes structurally resembling native viral ribonucleoprotein cores. J Biol Chem (1990) 1.89
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol (2000) 1.86
Identification of amino acid residues of influenza virus nucleoprotein essential for RNA binding. J Virol (1999) 1.80
Localization of RNA polymerases on influenza viral ribonucleoproteins by immunogold labeling. Virology (1988) 1.79
3D reconstruction in electron microscopy using ART with smooth spherically symmetric volume elements (blobs). Ultramicroscopy (1998) 1.78
Identification of an RNA binding region within the N-terminal third of the influenza A virus nucleoprotein. J Virol (1995) 1.76
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol (1997) 1.71
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis. J Virol (2000) 1.69
A hairpin loop at the 5' end of influenza A virus virion RNA is required for synthesis of poly(A)+ mRNA in vitro. J Virol (1999) 1.58
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replication. J Virol (1999) 1.47
The PA influenza virus polymerase subunit is a phosphorylated protein. J Gen Virol (1998) 1.33
Pattern recognition and classification of images of biological macromolecules using artificial neural networks. Biophys J (1994) 1.31
Replication of orthomyxoviruses. Adv Virus Res (1999) 1.27
Studies on the helical nucleocapsid of influenza virus. Virology (1982) 1.27
Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med (1997) 4.71
The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance--a review. Gene (1985) 3.42
The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer (1988) 3.29
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J (1994) 3.26
Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology (1983) 3.04
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood (2001) 2.99
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol (2000) 2.48
Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance. Nucleic Acids Res (1986) 2.45
Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus. Gene (1980) 2.44
Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic population: a prospective, double-blind, randomized and placebo-controlled study. J Am Coll Cardiol (2001) 2.36
Bacteriophage capsids: tough nanoshells with complex elastic properties. Proc Natl Acad Sci U S A (2004) 2.30
Structure of viral connectors and their function in bacteriophage assembly and DNA packaging. Q Rev Biophys (1994) 2.24
Bacillus subtilis phage phi29. Characterization of gene products and functions. Eur J Biochem (1976) 2.17
Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J Virol (1995) 2.16
Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker. Gene (1988) 2.03
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit. J Gen Virol (1994) 2.03
The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport. J Neurosci (1999) 2.03
Individual expression of influenza virus PA protein induces degradation of coexpressed proteins. J Virol (1995) 2.02
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates. EMBO J (1999) 2.00
Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein. J Virol (1997) 2.00
PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. J Virol (2001) 1.98
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome. Gene (1980) 1.95
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits. Nature (1999) 1.93
Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol (1994) 1.93
Sharpening high resolution information in single particle electron cryomicroscopy. J Struct Biol (2008) 1.93
Vaccinia virus 15-kilodalton (A14L) protein is essential for assembly and attachment of viral crescents to virosomes. J Virol (1998) 1.91
Analysis of electron microscope images and electron diffraction patterns of thin crystals of phi 29 connectors in ice. J Mol Biol (1994) 1.90
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure. Nucleic Acids Res (1996) 1.89
Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction. J Neurochem (1996) 1.88
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol (2000) 1.86
Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology (1985) 1.84
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system. J Gen Virol (1994) 1.83
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis. J Virol (1996) 1.79
Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J Gen Virol (1997) 1.79
Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses. J Gen Virol (1993) 1.74
A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol Cell Biol (1999) 1.74
Clinical importance of myeloid-antigen expression in acute lymphoblastic leukemia of childhood. N Engl J Med (1991) 1.72
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol (1997) 1.71
The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins. J Virol (1996) 1.69
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis. J Virol (2000) 1.69
Functional domains of the ClpA and ClpX molecular chaperones identified by limited proteolysis and deletion analysis. J Biol Chem (2001) 1.68
Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations. EMBO J (2000) 1.67
Proteins induced in Bacillus subtilis infected with bacteriophage phi 29. Virology (1973) 1.67
Soft phonon, dynamical fluctuations, and a reversible phase transition: indium chains on silicon. Phys Rev Lett (2006) 1.64
Evolution of the nucleotide sequence of influenza virus RNA segment 7 during drift of the H3N2 subtype. Gene (1983) 1.64
Expressed sequences from conidial, mycelial, and sexual stages of Neurospora crassa. Fungal Genet Biol (1997) 1.62
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. J Virol (1992) 1.61
Nuclear transport of influenza virus polymerase PA protein. Virus Res (1992) 1.59
Bacteriophage lambda preconnectors. Purification and structure. J Mol Biol (1984) 1.53
Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene (1986) 1.53
General morphology and capsid fine structure of African swine fever virus particles. Virology (1984) 1.52
Characterization of influenza virus PB1 protein binding to viral RNA: two separate regions of the protein contribute to the interaction domain. J Virol (1999) 1.52
Initial studies with high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brains of patients with progressive supranuclear palsy and Alzheimer disease. Cell Mol Biol (Noisy-le-grand) (2000) 1.51
Phenotypic hiding: the carryover of mutations in RNA viruses as shown by detection of mar mutants in influenza virus. J Virol (1989) 1.50
Purification and organization of the gene 1 portal protein required for phage P22 DNA packaging. Biochemistry (1988) 1.50
Characterization of ATP and DNA binding activities of TrwB, the coupling protein essential in plasmid R388 conjugation. J Biol Chem (1999) 1.50
A conserved motif in S-layer proteins is involved in peptidoglycan binding in Thermus thermophilus. J Bacteriol (1996) 1.50
Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains. Virus Res (1989) 1.49
pac gene as efficient dominant marker and reporter gene in mammalian cells. Methods Enzymol (1992) 1.48
The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation. Nucleic Acids Res (1997) 1.48
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replication. J Virol (1999) 1.47
Lung histopathological findings in fatal pandemic influenza A (H1N1). Med Intensiva (2011) 1.46
Topology of the components of the DNA packaging machinery in the phage phi29 prohead. J Mol Biol (2000) 1.45
Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant. J Gen Virol (1996) 1.43
Factors associated with outcome after cord blood transplantation in children with acute leukemia. Eurocord-Cord Blood Transplant Group. Blood (1999) 1.42
The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin. EMBO J (2001) 1.41
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit. J Virol (1996) 1.38
Characterization of a human astrovirus serotype 2 structural protein (VP26) that contains an epitope involved in virus neutralization. Virology (1994) 1.37
Bacteriophage T3 connector: three-dimensional structure and comparison with other viral head-tail connecting regions. J Mol Biol (1988) 1.34
The PA influenza virus polymerase subunit is a phosphorylated protein. J Gen Virol (1998) 1.33
Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res (1999) 1.32
Three-dimensional reconstruction of the connector of bacteriophage phi 29 at 1.8 nm resolution. J Mol Biol (1986) 1.31
A suppressor of nonsense mutations in Bacillus subtilis. Eur J Biochem (1974) 1.30
Regulated M1 mRNA splicing in influenza virus-infected cells. J Gen Virol (1991) 1.28
The capillarity of nanometric water menisci confined inside closed-geometry viral cages. Proc Natl Acad Sci U S A (2009) 1.27
Replication of orthomyxoviruses. Adv Virus Res (1999) 1.27
In vitro reconstitution of active influenza virus ribonucleoprotein complexes using viral proteins purified from infected cells. J Gen Virol (1992) 1.26
Overproduction and purification of the connector protein of Bacillus subtilis phage phi 29. Nucleic Acids Res (1984) 1.25
Assembly of Bacillus subtilis phage phi29. 1. Mutants in the cistrons coding for the structural proteins. Eur J Biochem (1977) 1.24
Membrane protein molecules of transmissible gastroenteritis coronavirus also expose the carboxy-terminal region on the external surface of the virion. J Virol (1995) 1.24
The synthesis of influenza virus negative-strand RNA takes place in insoluble complexes present in the nuclear matrix fraction. Virus Res (1990) 1.24
Biochemical markers and cardiac troponin I release after radiofrequency catheter ablation: approach to size of necrosis. Am Heart J (1998) 1.23
A precursor of the neck appendage protein of B. subtilis phage phi 29. FEBS Lett (1974) 1.23
C terminus of infectious bursal disease virus major capsid protein VP2 is involved in definition of the T number for capsid assembly. J Virol (2001) 1.22
The bacteriophage phi29 head-tail connector imaged at high resolution with the atomic force microscope in buffer solution. EMBO J (1997) 1.21
Structure of the head-tail connector of bacteriophage phi 29. J Mol Biol (1982) 1.21
Two types of virus-related particles are found during transmissible gastroenteritis virus morphogenesis. J Virol (1998) 1.21
Inducible expression of the vaccinia virus A17L gene provides a synchronized system to monitor sorting of viral proteins during morphogenesis. J Virol (1996) 1.20
3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin. Nat Struct Biol (1999) 1.19